Found 26 clinical trials
RNA Disruption Assay (RDA)-Breast Cancer Response Evaluation for Individualized Therapy
The current study aims to provide validation results of RNA Disruption Assay (RDA) as a tumour response assessment tool that uses tumour core biopsies taken starting from 35 +/- 4 days after the initiation of neoadjuvant chemotherapy.
- 28 views
- 28 May, 2021
- 36 locations
Letrozole in Post-Menopausal Patients With Operable Hormone-Sensitive Breast Cancer
A short pre-surgical non-therapeutic trial involving postmenopausal women with newly diagnosed eR+, HeR2-negative operable breast cancers. After undergoing a core needle biopsy for tissue
- 6 views
- 13 May, 2021
- 1 location
The MONET - Study: MR Mammography of Nonpalpable Breast Tumors
The purpose of this study is to determine whether performing MRI of the breast will improve breast cancer management by reducing the number of biopsies and in case of malignancy allowing one-stage surgical excision of the tumor.
- 4 views
- 07 Nov, 2020
- 1 location
Study of Neoadjuvant Chemotherapy Plus Trastuzumab and Pertuzumab in HER2-Negative Breast Cancer Patients With Abnormal HER2 Signaling
This is a prospective, single arm, open label, multicenter interventional study designed to evaluate the efficacy of neoadjuvant chemotherapy with anti-HER2 antibodies in patients with HER2-negative invasive breast cancer who have abnormal HER2 signaling activity determined by the Celcuity CELx HER2 Signaling Function (HSF) testing.
- 8 views
- 21 Apr, 2021
- 42 locations
Targeted Biopsy of Carbon Nanoparticles Labelled Axillary Node for cN+ Breast Cancer
To explore the feasibility of target biopsy of carbon nanoparticles labelled lymph node after neoadjuvant systemic therapy for cN+ breast cancer, and evaluate whether it can accurately predict axillary lymph node status after neoadjuvant systemic therapy.
- 0 views
- 30 Jan, 2021
- 1 location
Enhanced Bioscaffold for Volumetric Muscle Loss
This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix AB Surgical Graft in the restoration of function in the setting of volumetric muscle loss after soft tissue trauma.
- 0 views
- 27 Jan, 2021
- 1 location
The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed With Intraductal Papilloma Without Atypia or Flat Epithelial Atypia by Core Needle Biopsy
without atypia (IPWA) by core needle biopsy.
- 10 views
- 05 Mar, 2021
- 20 locations
Study of Core Needle Biopsy and Cryoablation of an Enlarging Tumor in Patients With Metastatic Lung Cancer and Metastatic Melanoma Receiving Post-progression Immune Checkpoint Inhibitor Therapy
This research study is studying cryoablation (a treatment to kill cancer cells with extreme cold) combined with continued treatment with current immune checkpoint inhibitor as a possible treatment for lung cancer.
- 3 views
- 05 Mar, 2021
- 1 location
Imipramine on ER+ve and Triple Negative Breast Cancer
Comparing changes in biomarkers from a diagnostic core needle biopsy to surgical pathology specimen or repeat core needle biopsy.
- 0 views
- 14 Mar, 2021
- 1 location
Contrast Enhanced Mammography in Diagnosing Patients With Suspicious Breast Findings
This pilot trial studies how well contrast enhanced mammography works in diagnosing patients with suspicious breast findings. Diagnostic procedures, such as contrast enhanced mammography, may help to reclassify findings seen on diagnostic mammography and ultrasound as benign or likely benign with what would otherwise require biopsy for confirmation.
- 0 views
- 01 Mar, 2021
- 1 location