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Found 22 clinical trials
RNA Disruption Assay (RDA)-Breast Cancer Response Evaluation for Individualized Therapy (BREVITY)

The current study aims to provide validation results of RNA Disruption Assay (RDA) as a tumour response assessment tool that uses tumour core biopsies taken starting from 35 +/- 4 days after the initiation of neoadjuvant chemotherapy.

breast cancer
cancer
invasive breast cancer
adjuvant therapy
  • 28 views
  • 03 Mar, 2022
  • 4 locations
Letrozole in Post-Menopausal Patients With Operable Hormone-Sensitive Breast Cancer

A short pre-surgical non-therapeutic trial involving postmenopausal women with newly diagnosed eR+, HeR2-negative operable breast cancers. After undergoing a core needle biopsy for tissue

breast cancer
cancer
lumpectomy
invasive breast cancer
mastectomy
  • 12 views
  • 22 Apr, 2022
  • 1 location
Study of Neoadjuvant Chemotherapy Plus Trastuzumab and Pertuzumab in HER2-Negative Breast Cancer Patients With Abnormal HER2 Signaling (FB-12)

This is a prospective, single arm, open label, multicenter interventional study designed to evaluate the efficacy of neoadjuvant chemotherapy with anti-HER2 antibodies in patients with HER2-negative invasive breast cancer who have abnormal HER2 signaling activity determined by the Celcuity CELx HER2 Signaling Function (HSF) testing.

doxorubicin
platelet count
progesterone receptor
pet-ct scan
paclitaxel
  • 8 views
  • 04 Mar, 2022
  • 42 locations
Targeted Biopsy of Carbon Nanoparticles Labelled Axillary Node for cN+ Breast Cancer

To explore the feasibility of target biopsy of carbon nanoparticles labelled lymph node after neoadjuvant systemic therapy for cN+ breast cancer, and evaluate whether it can accurately predict axillary lymph node status after neoadjuvant systemic therapy.

  • 0 views
  • 30 Jan, 2021
  • 1 location
Enhanced Bioscaffold for Volumetric Muscle Loss (MTEC VML)

This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix™ AB Surgical Graft in the restoration of function in the setting of volumetric muscle loss after soft tissue trauma.

  • 0 views
  • 27 Feb, 2022
  • 1 location
Assess the Use of rEBUS With a Guide Sheath to Increase Transbronchial Lung Biopsy Yield Rate

Whether using a guide sheath can increase the diagnostic yield rate after the lesion is located by radial endobronchial ultrasound

probe
endobronchial ultrasonography
  • 0 views
  • 28 Oct, 2021
  • 1 location
Optical Spectroscopy During Breast Cancer Surgery and Core Needle Biopsy

and test its performance as an adjunct to core needle biopsy. For the surgery part of the study, all patients scheduled to have a mastectomy or lumpectomy for the treatment of breast cancer will be

lumpectomy
mastectomy
core needle biopsy
cancer surgery
mammogram
  • 0 views
  • 23 Jan, 2022
  • 1 location
Study of Core Needle Biopsy and Cryoablation of an Enlarging Tumor in Patients With Metastatic Lung Cancer and Metastatic Melanoma Receiving Post-progression Immune Checkpoint Inhibitor Therapy

This research study is studying cryoablation (a treatment to kill cancer cells with extreme cold) combined with continued treatment with current immune checkpoint inhibitor as a possible treatment for lung cancer.

x-rays
cancer
lung cancer
ct scan
COPD
  • 8 views
  • 04 Mar, 2022
  • 1 location
Imipramine on ER+ve and Triple Negative Breast Cancer

Comparing changes in biomarkers from a diagnostic core needle biopsy to surgical pathology specimen or repeat core needle biopsy.

triple negative breast cancer
lobular carcinoma
carcinoma
core needle biopsy
ductal carcinoma
  • 0 views
  • 15 Feb, 2022
  • 1 location
Axillary Lymph Node Tattoo Marking Study

> Core needle biopsy and/or fine needle aspiration Surgical Removal of the Lymph Nodes via clip and radioseed guidance

core needle biopsy
  • 0 views
  • 24 Mar, 2022
  • 1 location