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Found 27 clinical trials
Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

This phase I trial studies the best dose and how well copanlisib when given together with nivolumab works in treating patients with Richter's transformation or transformed indolent non-Hodgkin

indolent non-hodgkin lymphoma
hodgkin's disease
monoclonal antibody therapy
lymphadenopathy
beta human chorionic gonadotrophin
  • 17 views
  • 09 Apr, 2022
  • 2 locations
Copanlisib With Ibrutinib for Patients With Recurrent/ Refractory Primary Central Nervous System Lymphoma (PCNSL)

The purpose of this study is to test the safety of combined use of the study drugs, copanlisib and ibrutinib, in people with PCNSL.

  • 10 views
  • 26 Apr, 2022
  • 7 locations
Copanlisib With Rituximab-Bendamustine in Patients With Relapsed-Refractory Diffuse Large B-cell Lymphoma

This is a multicentric single arm phase II trial, to investigate the efficacy (in terms of PFS) of the combination regimen rituximab-bendamustine in association with copanlisib in patients

  • 0 views
  • 16 May, 2022
  • 12 locations
Copanlisib in Combination With Rituximab and CHOP Chemotherapy in Patients With Previously Untreated DLBCL (COPA-R-CHOP)

This is a prospective, multicenter, non-randomized, open-label, phase II study to describe the efficacy of R-CHOP plus copanlisib including a safety run-in phase in order to detect early and

neutrophil count
high grade b-cell lymphoma
ejection fraction
gilbert's syndrome
b-cell lymphoma
  • 0 views
  • 05 Jun, 2022
  • 12 locations
Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer

This phase I/II trial studies the effects (good and bad) of adding copanlisib to the usual therapy of fulvestrant and abemaciclib in treating patients with hormone receptor positive and HER2

hormone therapy
stage iv breast cancer
everolimus
estrogen
cancer
  • 0 views
  • 13 Jul, 2022
  • 10 locations
Response-Adapted Therapy With Copanlisib and Rituximab in Untreated Follicular Lymphoma

other parts of the body. Researchers want to see if a combination of drugs can attack the cancer cells in people with FL. Objective To see if copanlisib plus

ct scan
lipase
oophorectomy
monoclonal antibodies
antibody therapy
  • 84 views
  • 27 Jul, 2022
  • 1 location
Copanlisib and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

This phase I/II trial studies the side effects, best dose, and effectiveness of copanlisib and venetoclax in treating patients with mantle cell lymphoma that has come back (relapsed) or does not

  • 0 views
  • 08 Aug, 2022
  • 1 location
Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations

This phase Ib trial studies side effects and best dose of copanlisib and olaparib when given together with durvalumab, and how well they work in treating patients with solid tumors that have

thromboplastin
olaparib
corticosteroids
glycosylated hemoglobin
cancer
  • 3 views
  • 24 Jul, 2022
  • 3 locations
Copanlisib With Dose-Adjusted EPOCH-R in Relapsed and Refractory Burkitt Lymphoma and Other High-Grade B-cell Lymphomas

want to see if a combination of drugs can help. Objective To learn if it is safe to give people with certain cancers copanlisib together with rituximab and

diffuse large b-cell lymphoma
vincristine
prednisone
etoposide
cancer chemotherapy
  • 0 views
  • 28 Jul, 2022
  • 1 location
Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN

This phase I/II trial studies the side effects and best dose of copanlisib when given together with nivolumab and ipilimumab and to see how well they work in treating patients with solid cancers

thromboplastin
antineoplastic
PTEN
glycosylated hemoglobin
cancer
  • 0 views
  • 11 Jul, 2022
  • 5 locations