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Found 9 clinical trials
A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet Syndrome

The main aim of the study is to learn if soticlestat, when given as an add-on therapy, reduces the number of convulsive seizures in children and young adults with Dravet Syndrome.

  • 0 views
  • 01 May, 2022
  • 12 locations
EPX-100 (Clemizole Hydrochloride) as Add-on Therapy to Control Convulsive Seizures in Patients With Dravet Syndrome (ARGUS)

The purpose of this study is to compare the efficacy of EPX-100 against placebo as adjunctive therapy in 60 patients with Dravet Syndrome.

clemizole hydrochloride
tonic
adjunctive therapy
tonic clonic convulsion
epilepsy
  • 63 views
  • 15 May, 2022
  • 8 locations
A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome

The primary purpose of the study is to demonstrate that lorcaserin has superior efficacy compared to placebo on percent change in frequency of convulsive seizures per 28 days in participants

  • 7 views
  • 18 Dec, 2021
  • 28 locations
REC2Stim as a Treatment for Refractory Epilepsy in the Primary Sensorimotor Cortex. (REC2Stim)

People with central lobe epilepsy (CLE), with seizures arising from the primary sensorimotor cortex, typically show a high rate of convulsive seizures that do not respond to anti-epileptic drugs

electrical stimulation
convulsive seizure
epilepsy
antiepileptic
anti-epileptic drug
  • 0 views
  • 17 Feb, 2022
  • 1 location
Modulating Movement Intention Via Cortical Stimulation

The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies. These results could provide preliminary data for subsequent studies evaluating local and global efficacy of plasticity-inducing treatments for PMD symptoms.

  • 13 views
  • 22 Aug, 2021
  • 1 location
Evaluating the Role of Inflammation in Neonatal Epileptogenesis (NSR-RISE)

The purpose of this study evaluate the relationship between inflammation and epilepsy in neonates with seizures after birth.

neurologic examination
electroencephalogram
epilepsy
eeg monitoring
seizure
  • 8 views
  • 22 Apr, 2022
  • 3 locations
Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Syncopation and Seizure

Changes of thyroid function may occur after short loss of consciousness, but they haven't been systematically evaluated up to now, although occasional observations suggest temporal increases in TSH concentration. This study aims at assessing transient changes of biomarkers of thyroid function after syncopation and seizure. Results of the study might …

  • 0 views
  • 30 May, 2021
  • 4 locations
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy

The researchers hope to explore the etiological distribution and influencing factors of KCNQ2-related neonatal convulsions or refractory epileptic encephalopathy, and to improve the level of assessment, identification, intervention and shunt of KCNQ2-related convulsions. To formulate countermeasures and measures for prevention, management and health education.

epilepsy
neonatal convulsions
seizure
  • 39 views
  • 22 Mar, 2022
  • 1 location
Neonatal Seizure Registry - Developmental Functional EValuation (NSR-DEV)

The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for developmental disabilities and whether these are modified by parent well-being.

neonatal seizures
neonatal convulsions
developmental disabilities
seizure
  • 13 views
  • 04 Mar, 2022
  • 7 locations