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Found 178 clinical trials
Technology-Supported Treatment of Sleep Apnea in Prediabetes (TECH)

. The proposed study will be the first to assess whether adding CPAP (continuous positive air pressure) treatment to a lifestyle intervention improves cardiometabolic outcomes beyond that achieved with

  • 11 Oct, 2022
  • 1 location
NCPAP+MISA vs. NIPPV+MISA to NRDS a Multicenter Randomized Study

MISA in the treatment of NRDS in premature infants under the initial respiratory support mode of nasal continuous positive airway pressure(NCPAP) and Non-invasive positive pressure ventilation (NIPPV

  • 05 Dec, 2021
  • 1 location
DISE: Phenotyping Obstruction Patterns (DISE-PhOP)

functional impact of anatomic and neuromuscular factors on airflow obstruction. The investigators will apply nasal pressure (CPAP) during DISE to generate pressure-flow and pressure-area relationships

  • 04 Oct, 2022
  • 1 location
Early PReserved SPONtaneous Breathing Activity in Mechanically Ventilated Patients With ARDS (PReSPON)

) reported less time on mechanical ventilation and in the intensive care unit (ICU) with preserved early spontaneous breathing activity during Airway Pressure Release Ventilation (APRV). Debate

  • 15 Feb, 2021
  • 1 location
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.

respiratory tract infection
stem cell transplantation
  • 19 Jun, 2022
  • 40 locations
Nasal Oxygen Therapy After Cardiac Surgery (NOTACS)

NOTACS aims to determine if prophylactic use of high-flow nasal therapy (for a minimum of 16 hours after tracheal extubation) increases days at home in the first 90 days after surgery, for adult patients undergoing cardiac surgery who are at high risk of postoperative pulmonary complications. The study also incorporates …

body mass index
pulmonary disease
  • 21 Apr, 2022
  • 1 location
VentFirst: A Multicenter RCT of Assisted Ventilation During Delayed Cord Clamping for Extremely Preterm Infants

The purpose of this study is to determine whether providing ventilatory assistance prior to umbilical cord clamping influences the occurrence of intraventricular hemorrhage (IVH) in extremely preterm (EPT) infants, compared to standard care of providing ventilatory assistance after cord clamping.

Accepts healthy volunteers
umbilical cord clamping
  • 04 Oct, 2022
  • 10 locations
Multisite Tissue Oxygenation Guided Perioperative Care in Cardiac Surgery

The BOTTOMLINE-CS trial is an international, open, single-center, pragmatic, randomised controlled trial to investigate whether multisite tissue oxygen saturation monitoring-guided perioperative care reduces composite complications within 30 days of randomization in off-pump coronary artery bypass grafting.

  • 13 Nov, 2021
  • 1 location
Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial). (POLAR)

Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating. Opening their lungs can be difficult, and once open the under-developed lungs of premature babies will often collapse again between each breath. To prevent this nearly all premature babies …

chronic lung disease
assisted ventilation
positive end expiratory pressure
mechanical ventilation
  • 28 Oct, 2022
  • 13 locations
Does the Use of Higher Versus Lower Oxygen Concentration Improve Neurodevelopmental Outcomes at 18-24 Months in Very Low Birthweight Infants - The HiLo-Trial (HiLo)

Preterm birth, or birth before 37 weeks' gestation, is increasingly common, occurring in 8 percent of pregnancies in Canada. Preterm birth is associated with many health complications, particularly when the birth happens before 29 weeks' gestation. At this gestational age, the lungs are not fully developed and it is not …

  • 21 Oct, 2022
  • 6 locations