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Found 178 clinical trials
Effectiveness of Combining Behavioral and Pharmacologic Therapy for Complex Insomnia in Veterans With PTSD (PRECEPT-D)

nightmares. Continuous positive airway pressure (CPAP) is the most effective therapy but adherence to treatment is suboptimal. Insomnia is considered a barrier to long-term adherence. The overarching theme

  • 20 Feb, 2022
  • 1 location
The Efficacy of Continuous Positive Airway Pressure in Achieving Asthma Control in Patients With Severe Asthma and Obstructive Sleep Apnea

, titration of CPAP pressure will be performed by conventional polysomnography or using auto-CPAP equipment using a validated protocol. The investigators aim in this study to examine the effect of CPAP

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
Muscle Strength Exercise and Sleep Apnea

, age, male gender, menopause, small jaw, sedative medications / drugs and alcohol. The most important treatment for sleep apnea is continuous positive airway pressure (CPAP). However, not all patients

obstructive sleep apnea
continuous positive airway pressure
  • 23 Apr, 2022
A Dose-Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFact

The purpose of this two-part Phase 2 study is to assess the safety, tolerability and efficacy of aerosolized SF-RI 1 (AeroFact) when delivered via nCPAP at two different doses.

  • 11 Mar, 2022
  • 29 locations
Alcohol and Neural Cardiovascular Control in Binge Drinkers

This study evaluates the impact of evening alcohol consumption on sympathetic activity and baroreflex function in binge drinkers. Our central hypothesis is that evening binge alcohol consumption will lead to sympathetic overactivity and blunted baroreflex function.

Accepts healthy volunteers
  • 20 Apr, 2022
  • 1 location
Myofunctional Training for Obstructive Sleep Apnea Patients After Transoral Robotic Surgery

Background: Obstructive Sleep Apnea Syndrome (OSA) is a kind of sleep disorder. The symptoms are intermittent, partial or complete upper airway collapse, seriously impacting oxygen saturation and oxidative stress. Some patients choose to do upper airway surgeries, but the success rate is only 60-70%. The symptoms might relapse because of …

  • 16 May, 2021
  • 1 location
Inspiratory Muscle Training in Difficult to Wean Patients

Prolonged mechanical ventilation secondary to weaning failure demands a significant amount of intensive care unit (ICU) resources, thus increasing the economic burden of public healthcare costs. One of the proposed mechanisms accounting for weaning failure is the concept that excessive work of breathing for weak respiratory muscles during the liberation …

mechanical ventilation
inspiratory muscle training
  • 12 Feb, 2022
  • 1 location
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy (SLEEP)

A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the

  • 30 Jun, 2022
  • 11 locations
Sleep for Stroke Management and Recovery Trial (Sleep SMART)

The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at …

recurrent strokes
acute stroke
obstructive sleep apnea
acute coronary syndrome
  • 14 Apr, 2022
  • 106 locations
Helmet NIV vs. CPAP vs. High-flow Nasal Oxygen in Hypoxemic Respiratory Failure (HENIVOT2)

Multicenter, open label, three-arm randomized trial to assess the effect of helmet noninvasive ventilation vs. helmet continuous positive airway pressure vs. high-flow nasal oxygen on the rate

pao2/fio2 ratio
assisted ventilation
  • 12 May, 2022
  • 1 location