constitutional symptoms Clinical Research Trials

Six Months Versus 12 Months of Oral Itraconazole Therapy for Management of Treatment na ve Subjects With CPA

The treatment options majorly consist of medical management with at least 6-month long treatment with antifungal drugs - most significantly the azole groups. Itraconazole is the preferred azole for the treatment of CPA. The duration of treatment with oral itraconazole remains uncertain. In a previous study the use of oral …

14 views
23 Jan, 2021
1 location

MethylphenIdate for Fatigue in Haematological Cancer

Cancer related fatigue (CRF) is the most debilitating problem for patients with haematological cancer. CRF severely reduces quality of life (QoL), functional capacity, impacts health behavior, recovery and furthermore no approved treatment exists. In solid cancer methylphenidat (MTP) has been suggested to improve CRF, however patients with haematological cancer has …

0 views
22 Jan, 2021
1 location

Ruxolitinib vs Allogeneic SCT for Patients With Myelofibrosis According to Donor Availability

The present study will be a multicenter, prospective phase II-study comparing efficacy of allogeneic SCT for patients with myelofibrosis who have a suitable stem cell donor after a 3 months Ruxolitinib induction therapy with patients who lack a suitable stem cell donor and will continue to receive Ruxolitinib.

platelet count

stem cell transplantation

ruxolitinib

thrombocytosis

24 views
23 Jan, 2021
28 locations

Trial of Belimumab in Early Lupus

This two year study will evaluate the effects of giving belimumab (Benlysta) to patients with Early Lupus. Early lupus is a diagnosis of lupus within 2 years. Subjects will be randomized to receive belimumab or placebo during the first year. During the second year, subjects who were randomized to belimumab …

belimumab

benlysta

corticosteroids

ds dna

hydroxychloroquine

0 views
25 Jan, 2021
1 location

SBRT and Oncolytic Virus Therapy Before Pembrolizumab for Metastatic TNBC and NSCLC

This is a Phase II trial to determine the efficacy and safety of stereotactic body radiation therapy (SBRT) and in situ oncolytic virus therapy used as a window of opportunity treatment before pembrolizumab in patients with metastatic triple negative breast cancer (TNBC) and metastatic non-small cell lung cancer (NSCLC). In …

liver metastasis

pembrolizumab

lymphoma

epidermal growth factor

cancer

82 views
22 Jan, 2021
1 location

Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts

This is a Phase I dose-escalation study to evaluate the safety of norovirus -specific T-cell (NST) therapy for chronic norovirus infection in participants following hematopoietic stem cell transplantation (HSCT) or with primary immunodeficiency disorders (PID) who have not undergone HSCT.

0 views
09 Jan, 2021
2 locations

Cohort of Patients Infected by an Arbovirus

by 4 different serotypes of virus. Dengue fever (DF) is defined by the sudden onset of fever with non-specific constitutional symptoms, recovery occurring spontaneously after 3 to 7 days. The

chikungunya

encephalitis

shock

myalgia

rhabdomyolysis

9 views
23 Jan, 2021
10 locations

Hydroxychloroquine Blood Levels in Primary Sj gren Syndrome Patients

systemic manifestations can also occur. Hydroxychloroquine (HCQ), an antimalarial immunomodulator, has been used for the treatment of arthralgias, myalgia and constitutional symptoms resulting from pSS

0 views
26 Jan, 2021
2 locations

Impact of HIV-infection on Clinical Characteristics and Outcomes on Stroke in Uganda

The investigators will recruit participants from three tertiary care hospitals in Uganda into an observational cohort study of people living with HIV/AIDS (PLWHA) and HIV-uninfected persons matched for gender and residency, presenting with CT-confirmed stroke. We will collect socio demographic, clinical, laboratory, radiologic, cardiac, and clinical neurologic disease measures to …

HIV Vaccine

AIDS

10 views
25 Jan, 2021
1 location

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