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Found 223 clinical trials
Visualising Cerebral and Peripheral Cholinergic Nerves in Patients With Dementia Lewy Bodies.

Lewy Body Dementia (DLB) is the second most common type of neurodegenerative dementia and characterized by loss of cholinergic neurons in the cerebrum and possibly also internal organs. A novel tracer, 18F-fluoroethoxybenzovesamicol (18F-FEOBV), binds to the cholinergic vesicle transporter, a protein expressed uniquely in the vesicles of cholinergic pre-synapses. Our …

Accepts healthy volunteers
cognitive assessment
cognitive impairment
  • 03 Jun, 2022
  • 1 location
CGRP Inhibition, Autonomic Function, and Migraine (CGRP-1)

The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e. whether they are between or during attacks) and whether the CGRP monoclonal antibody (mAb) …

Accepts healthy volunteers
  • 24 Apr, 2022
  • 1 location
CandeSpartan Study. Candesartan Spanish Response-prediction and Tolerability Study (CandeSpartan)

Observational, prospective, descriptive, open study on response predictors and tolerability of Candesartan in patients >18 years with episodic or chronic migraine with prior failure of three or more preventive drugs. Patients will receive Candesartan the same manner and intensity if they were not enrolled in the study. Vital signs, clinical …

headache disorder
chronic migraine
headache occurring
  • 26 Mar, 2022
  • 1 location