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Found 58 clinical trials
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Midostaurin Associated With Standard Chemotherapy in Patients With Core-binding Factor Leukemia

The purpose of this single-arm, open label, phase-II trial, is to determine whether the association of Midostaurin to standard induction, consolidation therapy and in maintenance therapy as single agent, is effective in decrease relapse incidence, in patients with CBF-AML. The single-arm, open label, phase-II study is based on data obtained …

  • 0 views
  • 01 Feb, 2021
  • 2 locations
None
Study of Azacytidine Combined With Lenalidomide As Maintenance Therapy Based on MRD Monitoring in AML

Great progress has been witnessed on the treatment of acute myeloid leukemia (AML) in recent years. However, elderly patients ineligible for receiving high dose chemotherapy and allo-HSCT, have high relapse rate and treatment-related complications. Azacitidine (AZA), a listed hypomethylating agent in China in 2018, is the only approved demethylating drug …

  • 0 views
  • 25 Jan, 2021
  • 2 locations
None
Fludarabine and Cytarabine as Continuous Infusion Plus G-CSF Priming for Elderly Patients With Resistant AML

- To determine the feasibility of fludarabine and cytarabine as continuous infusion plus granulocyte-colony stimulating factor priming for elderly patients with resistant acute myeloid leukemia other than acute promyelocytic leukemia - The feasibility will be evaluated in terms of toxicities, complete remission rate, duration of complete remission, disease-free survival, and …

fludarabine
remission
induction chemotherapy
colony stimulating factor
cell transplantation
  • 23 views
  • 07 Nov, 2020
  • 1 location
None
Intermittent Liposomal Amphotericin B Primary Prophylaxis

The purpose of this trial is to see which dose of liposomal amphotericin B is the safest when used as a preventer against invasive fungal infection in patients with acute leukaemia who are undergoing chemotherapy.

acute leukemia
  • 16 views
  • 07 Nov, 2020
  • 1 location
None
Evaluation of 2 Intensification Treatment Strategies for Neuroblastoma Patients With a Poor Response to Induction

The main objective is to evaluate the efficacy of two intensified consolidation strategies in very-high risk neuroblastoma (VHR-NBL) patients in terms of event-free survival from randomisation date. This evaluation will follow a hierarchical testing procedure: each experimental treatment will be first evaluated as a single-arm phase 2 study, and in …

  • 1 views
  • 11 Jun, 2021
  • 2 locations
None
Short-course Radiotherapy Versus Chemoradiotherapy Followed by Consolidation Chemotherapy and Selective Organ Preservation for MRI-defined Intermediate and High-risk Rectal Cancer Patients

/AIO-04/-12, both followed by consolidation chemotherapy, and surgery or a watch&wait (W&W) approach for patients with clinical complete response (cCR). The ACO/ARO/AIO-18.1 study

  • 0 views
  • 26 Jun, 2021
  • 72 locations
None
High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

This is an international multicenter, open-label, randomized phase III trial including three sequential randomizations to assess efficacy of induction and consolidation chemotherapies and

  • 1 views
  • 29 Sep, 2021
  • 7 locations
None
Study Investigating the Efficacy of Crenolanib With Chemotherapy vs Chemotherapy Alone in R/R FLT3 Mutated AML

This is a randomized, multi-center, double-blind, placebo-controlled study designed to evaluate the efficacy of crenolanib administered following salvage chemotherapy, consolidation chemotherapy

  • 39 views
  • 08 May, 2021
  • 104 locations
None
Study of Standard Intensive Chemotherapy Versus Intensive Chemotherapy With CPX-351 in Adult Patients With Newly Diagnosed AML and Intermediate- or Adverse Genetics

The trial is a randomized, open-label phase III study comparing CPX-351 vs conventional intensive induction and consolidation chemotherapy in patients with newly diagnosed AML and intermediate

consolidation therapy
consolidation chemotherapies
myelodysplasia
estrogen
hydroxyurea
  • 7 views
  • 29 Sep, 2021
  • 104 locations
None
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017

aim to overcome intrinsic chemotherapy resistance of the ALL cells. In patients with T-lineage ALL, who have particularly poor chances for cure after relapse, the established consolidation

pegaspargase
vincristine
mercaptopurine
doxorubicin
daunorubicin
  • 572 views
  • 18 Jul, 2021
  • 169 locations