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Found 720 clinical trials
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Efficacy, Safety, and Tolerability, of EN3835 vs Placebo in the Treatment of Plantar Fibromatosis

This randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of up to 2 treatments of EN3835 vs placebo in participants with plantar fibromatosis.

  • 0 views
  • 18 Jan, 2022
  • 18 locations
None
A Study to Evaluate the Safety, Tolerability and Efficacy of MHV370 in Participants With Sjogren's Syndrome (SjS) or Mixed Connective Tissue Disease (MCTD)

This study is a basket trial designed to establish safety, tolerability and efficacy of MHV370 in Sjögren's Syndrome (SjS) and Mixed Connective Tissue Disease (MCTD).

  • 0 views
  • 13 Jan, 2022
  • 5 locations
None
Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis

This is a 52 week, single center, randomized, double-blind, placebo-controlled study. After patients maintain a stable dose of Mycophenolate Mofetil (MMF) for at least 1 month, they will be randomized to treatment with either Belimumab & Rituximab or placebo.Patients in both groups will be on background MMF for the entirety …

rheumatism
progressive systemic sclerosis
rituximab
MRSS
lupus
  • 29 views
  • 10 Oct, 2021
  • 1 location
None
TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe Systemic Sclerosis

This early phase I trial studies the side effects and feasibility of total body irradiation using intensity modulation radiation therapy (IMRT) when given in combination with cyclophosphamide prior to stem cell transplant to treat severe systemic sclerosis. IMRT delivers total body radiation therapy more precisely and may reduce radiation exposure …

progressive systemic sclerosis
cancer
total body irradiation
cyclophosphamide
  • 0 views
  • 09 Nov, 2021
  • 1 location
None
Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre

Systemic sclerosis (SSc) is a rare form of connective tissue disease characterized by vascular involvement and the intensity of fibrosis. The lack of available treatment is largely due to the

rheumatism
progressive systemic sclerosis
fibrosis
raynaud's phenomenon
scleroderma
  • 0 views
  • 16 May, 2021
  • 1 location
None
A Study of FCX-013 Plus Veledimex for the Treatment of Moderate to Severe Localized Scleroderma (Morphea)

A two-component therapeutic consisting of FCX-013 and veledimex for the treatment of localized scleroderma (or morphea). The first component, FCX-013, is autologous human fibroblasts genetically-modified using lentivirus and encoded for matrix metalloproteinase 1 (MMP-1), a protein responsible for breaking down collagen. FCX-013 is designed to be injected under the skin …

immunosuppressive agents
immunosuppression
scleroderma
fibrosis
  • 33 views
  • 05 Feb, 2021
  • 2 locations
None
Safety and Efficacy of Anaerobic Cultivated Human Intestinal Microbiome Transplantation in Systemic Sclerosis (ReSScue)

This study evaluates the effect of intestinal microbiota therapy on gastro-intestinal symptoms in patients with systemic sclerosis (SSc). This is a mulicenter randomized controlled trial conducted at university hospitals in Oslo, Troms, Bergen and Trondheim in Norway. In part A1, half of the patients will receive active substance (intestinal microbiota …

progressive systemic sclerosis
  • 20 views
  • 28 Apr, 2021
  • 4 locations
None
Subcutaneous Injections of Autologous ASC to Heal Digital Ulcers in Patients With Scleroderma.

Ischemic digital ulcers (DUs) are a frequent complication in systemic sclerosis with a major impact on hand function and quality of life. Digital injection of autologous cultured adipose-derived stromal constitutes a promising approach to treat scleroderma-induced refractory ischemic DUs where no alternative therapy is validated. The aim of this phase …

progressive systemic sclerosis
digital ulcer
follicle stimulating hormone
scleroderma
  • 0 views
  • 25 Jan, 2021
  • 6 locations
None
RElevance of UltraSonography for Assessing Salivary Gland Involvement in Systemic Sclerosis (SSc)

As fibrosis of salivary glands is supposed to be the main mechanism involved in Systemic sclerosis (SSc)-associated sicca syndrome, Ultrasonography , biopsy and measuring gland elasticity (by ARFI (Acoustic Radiation Force Impulse)) in SSc patients could also constitute a relevant method to assess the potential alterations of echostructure of major …

fibrosis
  • 0 views
  • 24 Nov, 2021
  • 3 locations
None
Trial on Outpatients With Systemic Sclerosis Treated With Well-Being Therapy or With a Control Therapy

Systemic sclerosis (SSc) is a rare and potentially life-threatening autoimmune disorder with a significant impact on health and quality of life. The non-pharmacological interventions address to psychological sequalae currently available are limited and have poor efficacy. Well-Being Therapy (WBT) is a brief psychotherapy which has shown efficacy in decreasing the …

  • 0 views
  • 27 Jan, 2021
  • 2 locations