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Found 1004 clinical trials
Testing the Value of Novel Strategy and Its Cost Efficacy in Order to Improve the Poor Outcomes in Cardiogenic Shock

Cardiogenic shock (CGS) affects up to 10% of patients suffering acute coronary syndrome. It has a 30 day mortality of 45-50%. No pharmacological nor intervention/device trials have had any impact on this mortality in the last 20 years. The EURO SHOCK Trial (supported by the European Union Horizons 2020 programme) …

  • 12 May, 2021
  • 47 locations
REACH- Reducing Risk With E-based Support for Adherence to Lifestyle Change in Hypertension

This randomized controlled trial will evaluate whether preventive e-Counseling (Heart and Stroke Foundation Action Plan, HSF-AP; improves blood pressure and lifestyle adherence among subjects diagnosed with Stage 1 or 2 hypertension. Primary hypotheses. 1. e-Counseling (vs. Control) will significantly reduce SBP, DBP and pulse pressure (PP) at the 4-, …

  • 07 Nov, 2020
  • 3 locations
Impact of CardiolRx on Myocardial Recovery in Patients With Acute Myocarditis (ARCHER)

Multi-center, double-blind, placebo-controlled, parallel group design. Patients with myocarditis will be screened and, if eligible, randomized within 10 days of the diagnostic CMR to CardiolRx or placebo. CardiolRx is pharmaceutically produced Cannabidiol and is free of tetrahydrocannabinol (THC<5 ppm). The treatment period is 12 weeks; a last follow-up visit is …

  • 17 Sep, 2023
  • 26 locations
Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial (TREAT-MS)

FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun. It is unclear if, in the relapsing phase, there is an advantage of early aggressive therapy with respect to preventing long-term disability. The infectious risks and other …

  • 03 Apr, 2023
  • 40 locations
Breast Cancer Toxicity (CANTO)

The aims of the cohort will be to quantify impact of cancer treatments toxicities , and to generate predictors of chronic toxicity in patients with non-metastatic breast cancer. The project will include four specific aims : To develop a database of chronic treatment related toxicity in a cohort of 14750 …

Accepts healthy volunteers
  • 19 Apr, 2022
  • 1 location
Perioperative Individualized Optimization of Mean Arterial Pressure in Cardiac Surgery (OPTIPAM)

Neurologic and renal complications frequently occur after cardiac surgery. Acute renal failure following cardiac surgery increase the risk of chronic kidney disease, while postoperative neurological complications increased the risk of chronic cognitive dysfunction. Many cardiac surgical patients suffer from systemic hypertension, but the goal in clinical practice is to maintain …

  • 05 Sep, 2023
  • 1 location
Chronic Heart Failure - COngestion eValuation (CHF-COV)

Heart failure (HF) is a significant cause of death and the leading cause of hospitalization in patients over 65 years of age. Congestion is the main source of symptoms and the leading cause of

  • 09 Jul, 2022
  • 1 location
Acute Heart Failure - COngestion Discharge Evaluation (AHF-CODE)

Acute heart failure (AHF) is a major public health problem, associated with a 40% risk of death or re-hospitalisation at 3 months. This risk is significantly increased by insufficient

pulmonary congestion
natriuretic peptide
  • 23 Mar, 2022
  • 1 location
Inspiratory Muscle Training in Heart Failure

The aim of this study is to investigate the potential effects of inspiratory muscle training on cardiovascular, respiratory, physical, and psychosocial functions in patients with heart failure

  • 04 Oct, 2022
  • 1 location
TRICuspid Intervention in Heart Failure Trial (TRICI-HF)

Heart Failure trial (TRICI-HF trial) will assess the concept that TTVT will translate into a reduced morbidity and mortality. Patients will be randomly assigned in a 2:1 fashion to TTVT plus OMT

  • 04 Oct, 2022
  • 3 locations