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Found 1320 clinical trials
Balloon vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis

prosthesis patient mismatch is defined by effective orifice area (EOAi) 0.65 cm2/m2 2. Safety endpoint at 1 year defined by the composite of all-cause death, disabling stroke, rehospitalization for heart

transcatheter aortic valve implantation
aortic valve replacement
regurgitation
stenosis
tavi
  • 0 views
  • 05 Oct, 2021
  • 11 locations
Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD) (PROTECT-ICD)

ventricular fibrillation (VF) in participants without an ICD. Secondary endpoints will include all-cause mortality, non-sudden cardiovascular death, non-fatal repeat MI, heart failure and inappropriate ICD

  • 267 views
  • 15 May, 2022
  • 26 locations
Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH) (A DUE)

Combination therapy in pulmonary arterial hypertension (PAH) has been the subject of active investigation for more than a decade, with the benefit of targeting different pathways known to be involved in the pathogenesis of the disease. Adherence to prescribed therapy has an impact on clinical outcomes. Reducing the pill/tablet count …

  • 226 views
  • 30 Jun, 2022
  • 122 locations
REACH- Reducing Risk With E-based Support for Adherence to Lifestyle Change in Hypertension

This randomized controlled trial will evaluate whether preventive e-Counseling (Heart and Stroke Foundation Action Plan, HSF-AP; http://ww2.heartandstroke.ca/hs_bp2.asp?media=bp) improves blood pressure and lifestyle adherence among subjects diagnosed with Stage 1 or 2 hypertension. Primary hypotheses. 1. e-Counseling (vs. Control) will significantly reduce SBP, DBP and pulse pressure (PP) at the 4-, …

stroke
  • 259 views
  • 07 Nov, 2020
  • 3 locations
Testing the Value of Novel Strategy and Its Cost Efficacy in Order to Improve the Poor Outcomes in Cardiogenic Shock

Cardiogenic shock (CGS) affects up to 10% of patients suffering acute coronary syndrome. It has a 30 day mortality of 45-50%. No pharmacological nor intervention/device trials have had any impact on this mortality in the last 20 years. The EURO SHOCK Trial (supported by the European Union Horizons 2020 programme) …

  • 0 views
  • 12 May, 2021
  • 47 locations
Effect of Lactulose and/or Polyethylene Glycol Solution for Bowel Preparation for Colonscopy Procedures

Colonoscopy is the most useful exam used to evaluate colorectal diseases, like colorectal polyps and cancer. The appropriate bowel preparation is indispensable for colonoscopy procedures. Polyethylene glycol solution (PEG) is the most frequent laxative medication. However, the taste is poor, and patients need to drink a lot of liquids to …

Accepts healthy volunteers
  • 0 views
  • 21 Oct, 2021
  • 1 location
Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial (TREAT-MS)

FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun. It is unclear if, in the relapsing phase, there is an advantage of early aggressive therapy with respect to preventing long-term disability. The infectious risks and other …

  • 409 views
  • 23 May, 2022
  • 39 locations
Breast Cancer Toxicity (CANTO)

The aims of the cohort will be to quantify impact of cancer treatments toxicities , and to generate predictors of chronic toxicity in patients with non-metastatic breast cancer. The project will include four specific aims : To develop a database of chronic treatment related toxicity in a cohort of 14750 …

Accepts healthy volunteers
  • 0 views
  • 19 Apr, 2022
  • 1 location
Speeding the Weaning up: Aggressive Screening Criteria and Higher Minimal Ventilatory Settings.

Hypothesis In patients with less than 4 high risk factors for reintubation excluding body mass index >30 and hypercapnia during the spontaneous breathing trial (SBT) (low and intermediate risk for extubation failure), who receive preventive therapy with high flow nasal cannula (HFNC), the use of SBT with "HIGH minimal ventilator …

  • 0 views
  • 03 May, 2021
  • 1 location
Respiratory Muscle Function in Heart Failure

This study is being done because investigators are trying to determine how respiratory muscle and lung function influence the exercise responses in heart failure and healthy participants

Accepts healthy volunteers
  • 1 views
  • 25 Mar, 2022
  • 1 location