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Found 520 clinical trials
Efficacy, Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney Disease (MIRACLE)

The purpose of the study is to evaluate the efficacy and safety of AZD9977 in combination with dapagliflozin compared with dapagliflozin alone and to assess the dose-response relationship, dapagliflozin alone and 3 doses of AZD9977 combined with dapagliflozin on urinary albumin to creatinine ratio (UACR). The study will be conducted …

ejection fraction
loop diuretic
natriuretic peptide
MRI
nt-probnp
  • 22 views
  • 26 Jul, 2022
  • 82 locations
Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% (FINEARTS-HF)

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits …

stroke
ejection fraction
natriuretic peptide
nt-probnp
heart disease
  • 84 views
  • 25 Jul, 2022
  • 616 locations
Two Seawater-based Formulations for Relief of Nasal Congestion in Paediatric Subjects

The objective of this clinical trial is to evaluate the tolerance and efficacy of two Stérimar nasal sprays products in children who have nasal congestion due to the common cold.

cough
nasal congestion
rhinorrhea
cold
congestion
  • 0 views
  • 19 Mar, 2022
  • 1 location
CHF-COV Reduced (Chronic Heart Failure With Reduced Ejection Fraction - COngestion eValuation)

Heart failure (HF) is a significant cause of death and the leading cause of hospitalization in patients over 65 years of age. Congestion is the main source of symptoms and the leading cause of

  • 0 views
  • 26 Dec, 2021
  • 1 location
Safety & Feasibility of DSR TherApy in Heart FAiluRe pAtients With Persistent Congestion

Feasibility and safety study of the alfapump DSR system in the treatment of volume overloaded heart failure subjects receiving high doses of loop diuretics. Up to 24 subjects will be enrolled in up to 3 centres in Republic of Georgia, and randomized into 2 parallel treatment arms. Once implanted with …

fluid overload
loop diuretic
diuretics
nt-probnp
edema
  • 0 views
  • 09 Jun, 2021
  • 2 locations
Portal Vein Flow Variability to Quantify Right-Sided Hemodynamic Congestion (PORTAL) (PORTAL)

This study evaluates the accuracy of a comprehensive venous Doppler echography including the portal vein pulsatility index (PVPI) to quantify invasively measured right-sided venous pressures. A substudy will correlate invasive and non-invasive hemodynamic measurements to ballistocardiography and seismocardiography with the Kino-cardiograph (Kino) device (HeartKinetics, Waterloo, Belgium).

  • 0 views
  • 13 Jun, 2022
  • 1 location
Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea

per hour of sleep in subjects with perennial allergic or non-allergic rhinitis and mild obstructive sleep apnea who have persistent nasal congestion despite maximum doses of NGCS.

apnea-hypopnea index
obstructive sleep apnea
  • 90 views
  • 14 Feb, 2022
  • 1 location
Hypertonic Saline Therapy in Ambulatory Heart Failure Unit.

. The hypothesis is that the combination therapy will increase the diuresis volume at 3 hours and improve congestion parameters at 7 days.

  • 0 views
  • 02 May, 2022
  • 7 locations
Pelvic Pain Treated With MR-guided Cryoanalgesia

Pelvic pain syndromes have a high prevalence of up to 8% in the general population and up to 50% following pelvic trauma and pelvic surgery. While medical management is the initial therapeutic step, it is often ineffective with surgical decompression and resection of the putative nerves being the ultima ratio. …

analgesics
conservative management
pain relief
NSAID
  • 47 views
  • 17 Feb, 2022
  • 1 location
APCext : Effect of Temporary Porto-caval Shunt During Liver Transplantation on Function of Liver Graft From Extended Criteria Donor (APCext)

, the clamping of the portal vein induces blood congestion in the splanchnic territory leading to increased gut permeability, bacterial translocation and release of endotoxin and pro-inflammatory

reperfusion injury
liver disease
organ transplantation
orthotopic liver transplant
hepatitis
  • 229 views
  • 14 May, 2022
  • 5 locations