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Found 508 clinical trials
CLCZ696B2319E1 OL Extension Study to Evaluate Long-term Safety of Sacubitril/Valsartan in Pediatric Patients With HF

The purpose of this study is to evaluate long-term safety and tolerability data in eligible CLCZ696B2319 (PANORAMA-HF) patients receiving open-label sacubitril/valsartan.

valsartan
  • 73 views
  • 05 Jun, 2022
  • 51 locations
TRISCEND II Pivotal Trial

Pivotal trial to evaluate the safety and effectiveness of the Edwards EVOQUE tricuspid valve replacement system

regurgitation
medical therapy
  • 8 views
  • 25 Jul, 2022
  • 50 locations
SyncAV Post-Market Trial (SyncAV)

The SyncAV Post-Market Trial is a prospective, randomized, multi-center trial performed to determine if cardiac resynchronization therapy (CRT) devices programmed with SyncAV ON improve long-term CRT response compared to devices programmed with conventional CRT through evaluation of changes in left ventricular (LV) reverse remodeling.

left bundle branch block
medical therapy
cardiac resynchronization therapy
implantable cardioverter-defibrillators
aldosterone
  • 0 views
  • 26 Jul, 2022
  • 101 locations
Mid-Q Response Study

The Mid-Q Response study is a prospective, multi-center, randomized controlled, interventional, single-blinded, post-market study. The purpose of the Mid-Q Response study is to test the hypothesis that the AdaptivCRT (aCRT) algorithm is superior to standard CRT therapy regarding patient outcomes in CRT indicated patients with moderate QRS duration, preserved atrioventricular …

left bundle branch block
medical therapy
ejection fraction
angiotensin ii receptor antagonists
beta-adrenergic blocking agents
  • 6 views
  • 26 Jul, 2022
  • 57 locations
The EMPOWER Trial - The Carillon® Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

The objective of this prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the CARILLON Mitral Contour System in treating heart failure with at least mild functional regurgitation.

regurgitation
nt-probnp
functional mitral regurgitation
ejection fraction
cardiomyopathy
  • 97 views
  • 01 Mar, 2022
  • 43 locations
Intravenous Iron in Patients With Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality (FAIR-HF2)

The purpose of this study is to determine whether intravenous iron supplementation using ferric carboxymaltosis (FCM) reduces hospitalisation and mortality in patients with iron deficiency and heart failure.

iron
systolic heart failure
iron deficiency anemia
malnutrition
chronic heart failure
  • 13 views
  • 24 Feb, 2022
  • 32 locations
The ARIES HeartMate 3 Pump IDE Study

Prospective, randomized, double-blinded, placebo-controlled clinical investigation of advanced heart failure patients treated with the HM3 with two different antithrombotic regimens: vitamin K antagonist with aspirin versus vitamin K antagonist with placebo

aspirin
heart failure
  • 8 views
  • 11 Aug, 2022
  • 48 locations
Efficacy, Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney Disease (MIRACLE)

The purpose of the study is to evaluate the efficacy and safety of AZD9977 in combination with dapagliflozin compared with dapagliflozin alone and to assess the dose-response relationship, dapagliflozin alone and 3 doses of AZD9977 combined with dapagliflozin on urinary albumin to creatinine ratio (UACR). The study will be conducted …

antihypertensive drugs
body mass index
nt-probnp
hypertension
MRI
  • 22 views
  • 26 Jul, 2022
  • 82 locations
Dapagliflozin Effects on Cardiovascular Events in Patients With an Acute Heart Attack (DAPA-MI)

This study will evaluate the effect of dapagliflozin versus placebo, given once daily in addition to Standard of Care (SoC) therapies for patients with myocardial infarction (MI), for the prevention of hospitalisation for heart failure (HHF) or cardiovascular (CV) death.

ventriculogram
ejection fraction
infarct
cardiac mri
MRI
  • 8 views
  • 03 Jul, 2022
  • 91 locations
Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% (FINEARTS-HF)

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits …

stroke
heart disease
nt-probnp
natriuretic peptide
diuretic therapy
  • 84 views
  • 25 Jul, 2022
  • 620 locations