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Found 520 clinical trials
Pulmonary Artery Sensor System Pressure Monitoring to Improve Heart Failure (HF) Outcomes

Randomized, parallel group controlled study examines the effect of supporting the Heart failure supply through pulmonary arterial (PA) pressure measurement with the CardioMEMS™ HF system to hard endpoints, safety and quality of life. The target population consists of heart failure (HF) patients who have been predominantly in New York Heart …

heart failure
ejection fraction
  • 0 views
  • 23 Mar, 2022
  • 28 locations
Digoxin Evaluation in Chronic Heart Failure: Investigational Study In Outpatients in the Netherlands (DECISION)

Digoxin is the oldest, market-authorized drug for heart failure (HF), and very cheap. A large trial with digoxin, the DIG trial, executed in the early nineties revealed a highly significant reduction in HF hospitalizations, but no effect on mortality. A post-hoc analysis of the DIG trial suggests that low serum …

chronic heart failure
nt-probnp
heart failure
b-type natriuretic peptide
digoxin
  • 5 views
  • 16 Mar, 2022
  • 36 locations
Effectiveness of CRD-740 in Heart Failure (CARDINAL-HF)

This is a two-part study evaluating the effectiveness of CRD-740 in patients with either Heart Failure with Reduced Ejection Fraction (HFrEF) or Heart Failure with Preserved Ejection Fraction (HFpEF) after 12 weeks of treatment. The primary objective in Part A is to assess the effect of CRD-740 compared to placebo …

  • 0 views
  • 15 Jun, 2022
DANHEART (H-HeFT and Met-HeFT) (DANHEART)

The present study is testing in a combined design to types of drugs in patients with chronic heart failure: 1) Hydralazine in combination with isosorbide dinitrate (BiDil) and 2) Metformin hydrochloride. The study is double blind, placebo controlled. The first hypothesis is that hydralazine in combination with isosorbide dinitrate can …

angiotensin ii receptor antagonists
oral glucose tolerance test
insulin
metformin
diabetes
  • 62 views
  • 03 Mar, 2022
  • 23 locations
Home Hospital for Suddenly Ill Adults

The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be delivered in the home with equal quality and safety, reduced cost, and improved patient …

COPD
asthma
heart failure
pneumonia
nephropathy
  • 23 views
  • 03 Mar, 2022
  • 1 location
Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2) (PICSI-H)

The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over time, and across settings and providers. This study is particularly interested in understanding the effect …

cancer
psychological symptoms
dementia
liver disease
vascular disease
  • 0 views
  • 21 Mar, 2022
  • 2 locations
Facilitating Communication Study (FCS2)

This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their families to secure care in line with patients' goals of care over an illness trajectory, …

cancer
COPD
subarachnoid hemorrhage
dementia
acute illness
  • 590 views
  • 07 Feb, 2022
  • 3 locations
Mid-Q Response Study

The Mid-Q Response study is a prospective, multi-center, randomized controlled, interventional, single-blinded, post-market study. The purpose of the Mid-Q Response study is to test the hypothesis that the AdaptivCRT (aCRT) algorithm is superior to standard CRT therapy regarding patient outcomes in CRT indicated patients with moderate QRS duration, preserved atrioventricular …

angiotensin ii receptor antagonists
beta-adrenergic blocking agents
ejection fraction
left bundle branch block
medical therapy
  • 0 views
  • 27 Feb, 2022
  • 53 locations
Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC (PARACHUTE-HF)

The purpose of this study is to evaluate the effect of sacubitril/valsartan 200 mg BID compared with enalapril 10 mg BID, in addition to conventional heart failure (HF) treatment, in improving a hierarchical composite of cardiovascular (CV) events (i.e. CV death or the occurrence of first HF hospitalization) and causing …

natriuretic peptide
ejection fraction
ventricular angiography
valsartan
enzyme-linked immunosorbent assay
  • 0 views
  • 01 Mar, 2022
  • 44 locations
Efficacy, Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney Disease (MIRACLE)

The purpose of the study is to evaluate the efficacy and safety of AZD9977 in combination with dapagliflozin compared with dapagliflozin alone and to assess the dose-response relationship, dapagliflozin alone and 3 doses of AZD9977 combined with dapagliflozin on urinary albumin to creatinine ratio (UACR). The study will be conducted …

natriuretic peptide
potassium
ejection fraction
MRI
body mass index
  • 20 views
  • 14 May, 2022
  • 37 locations