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Found 522 clinical trials
HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection (HEARTBiT)

Heart transplantation is a life saving therapy for people with end stage heart failure. Acute rejection, a process where the immune system recognizes the transplanted heart as foreign and mounts a response against it, remains a clinical problem despite improvements in immunosuppressive drugs. Acute rejection occurs in 20-30% of patients …

heart transplantation
blood test
Accepts healthy volunteers
heart failure
  • 26 May, 2022
  • 4 locations
CentriMag Failure-to-Wean Post Approval Study

The primary objective of this Post Approval Study is to report the proportion of patients surviving to 30 days post CentriMag support or to hospital discharge, whichever is longer. For subjects who do not recover and are bridged to a heart transplant or a long-term assist device, the primary endpoint …

  • 08 Dec, 2021
  • 12 locations
The Use of the EXCOR Active Driving Unit for Mobilization of Pediatric Patients With Ventricular Assist Device Support (E-Motion)

The purpose of this observational study is to evaluate the performance of the Berlin Heart EXCOR Active driving unit while being used with the approved EXCOR ventricular assist device system.

  • 07 Mar, 2022
  • 1 location
Predictors of Non-accESs to therapeutiC EducAtion Programs Among Patients With Type 2 Diabetes, and/or Asthma, and/or Chronic Heart Failure in an Emergency Setting (ESCAPE)

Chronic diseases are frequent and potentially severe. Type II diabetes, asthma and heart failure affect 3.3 million, 4 million and 1 million people respectively in France. They are sources of avoidable mortality as well as disabilities leading to a loss of years of full health life (DALYS). Cumulatively, they were …

chronic disease
diabetic foot
chronic heart failure
heart failure
  • 02 May, 2022
  • 1 location
MRI of Myocardial Infarction (MRIMI)

Heart failure (HF) is an enormous health burden affecting approximately 5.1 million people in the US and is the cause of 250,000 deaths each year. Approximately 50% of HF is caused by myocardial ischemia and requires immediate restoration of coronary blood flow to the affected myocardium. However, the success of …

left ventricular remodeling
medical therapy
troponin i
creatine kinase
  • 03 Mar, 2022
  • 1 location
Observational Trial of Cardiotoxicity in Patients Undergoing Chemotherapy. (PROMETEY)

Advances in treatment have led to improved survival of patients with cancer, but have also increased morbidity and mortality due to cancer treatment side effects. Cardiotoxicity is one the most frequent side effect which may lead to premature morbidity and death among cancer survivors. The most concerning cardiovascular complications of …

sudden cardiac death
myocardial dysfunction
absolute neutrophil count
myocardial injury
  • 15 Feb, 2022
  • 1 location
Cancer Therapy Effects on the Heart (CTEH)

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to …

diagnostic tests
heart failure
  • 26 Feb, 2022
  • 1 location
Optimising Secondary Prevention and Quality of Life in Early Cardiac Rehabilitation

The primary aim of this research is to explore the adherence and drop-out from early cardiac rehabilitation (CR), to inform interventions to support patient's adherence to CR and facilitate maintenance. The secondary aim is to understand which aspects of CR are essential for improving health-related quality of life in the …

cardiac rehabilitation
bypass graft
coronary artery bypass graft
myocardial infarction
heart failure
  • 17 Nov, 2021
  • 6 locations
Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Congestive Heart Failure Receiving Therapy for Breast Cancer

This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with congestive heart failure receiving therapy for breast cancer. Studying samples of germline DNA in the laboratory from patients with congestive heart failure receiving therapy for breast cancer may help doctors …

biomarker analysis
breast cancer
  • 10 Apr, 2022
  • 1 location
The SWEDEGRAFT Right-Heart-Substudy

BACKGROUND Right ventricular dysfunction is a common echocardiographic finding after cardiac surgery. Pericardial disruption has been suggested as the most probable cause as the phenomenon occurs within minutes after pericardial incision. The investigators suspect that validated two-dimensional echocardiographic measures for right ventricular function might not reflect the altered RV contraction …

natriuretic peptide
b-type natriuretic peptide
  • 03 Dec, 2021
  • 1 location