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Found 501 clinical trials
Cancer Therapy Effects on the Heart (CTEH)

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to …

electrocardiogram
MRI
cardiac mri
heart failure
metastasis
  • 6 views
  • 26 Feb, 2022
  • 1 location
PLASMA Chile (PLASMA Chile)

Prospective, multicenter, observational cohort study to collect data on Chilean patients diagnosed with Heart Failure with reduced ejection fraction, their treatments, and their progress in a real-world environment. Additional objectives will be analyzed, such as mortality, and the barriers, if any, to receiving the indicated treatment.

ejection fraction
heart failure
  • 0 views
  • 13 Dec, 2021
  • 8 locations
MRI of Myocardial Infarction (MRIMI)

Heart failure (HF) is an enormous health burden affecting approximately 5.1 million people in the US and is the cause of 250,000 deaths each year. Approximately 50% of HF is caused by myocardial ischemia and requires immediate restoration of coronary blood flow to the affected myocardium. However, the success of …

myocardial infarction
electrocardiogram
infarct
creatine kinase
artery disease
  • 66 views
  • 07 Oct, 2022
  • 1 location
Evaluating Mobile Health Tool Use for Capturing Patient-centered Outcomes Measures in HF Patients

The Food and Drug Administration (FDA) recognizes the importance of developing patient-centric endpoints that are relevant to patients beyond mortality and hospitalizations. Patients with HF have reduced function capacity and quality of life (QoL) and hence it is imperative to explore interventions that impact endpoints that directly measure how a …

heart failure
diuretics
  • 0 views
  • 04 Jun, 2022
  • 6 locations
One Day Implantation Program for Heart Failure Patients Implanted With CRT-P (OEDIPE-CRT-P)

This study has been implemented to evaluate cardiac resynchronization therapy pacemaker (CRT-P) implantations on a same-day basis

cardiac resynchronization therapy
crt-p
heart failure
  • 0 views
  • 07 Oct, 2022
  • 14 locations
REDUCE LAP-HF III Corvia Protocol 1701

This is a post market trial to be conducted at sites in Germany. The device has CE approval in the EU. The purpose of this observational registry is to collect post market data in consecutive patients treated with the IASD System II, to further evaluate efficacy, safety and quality of …

heart failure
  • 18 views
  • 08 Oct, 2021
  • 24 locations
Early Treatment of Heart Failure: a Non-interventional Observational Study Program of Patients With Heart Failure and Initiated on Dapagliflozin (EVOLUTION-HF - UK) (EVOLUTION-HF)

Heart failure (HF) is a global, public health issue that affects more than 63 million people worldwide; this burden is expected to increase substantially as the population ages. Despite advancements in treatment, a HF diagnosis still leads to significant morbidity and mortality; there is also an immense impact on patients' …

diabetes
ejection fraction
heart failure
  • 2 views
  • 11 Oct, 2022
  • 10 locations
Exploratory Next Generation Sequencing to Identify Causative Variants for Therapy-Induced Congestive Heart Failure From Breast Cancer Study E5103 Germline DNA Samples

This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with congestive heart failure receiving therapy for breast cancer. Studying samples of germline DNA in the laboratory from patients with congestive heart failure receiving therapy for breast cancer may help doctors …

anthracyclines
bevacizumab
biomarker analysis
anthracycline
breast cancer
  • 23 views
  • 24 Oct, 2022
  • 1 location
The SWEDEGRAFT Right-Heart-Substudy

BACKGROUND Right ventricular dysfunction is a common echocardiographic finding after cardiac surgery. Pericardial disruption has been suggested as the most probable cause as the phenomenon occurs within minutes after pericardial incision. The investigators suspect that validated two-dimensional echocardiographic measures for right ventricular function might not reflect the altered RV contraction …

natriuretic peptide
b-type natriuretic peptide
  • 0 views
  • 03 Dec, 2021
  • 1 location
CentriMag Failure-to-Wean Post Approval Study

The primary objective of this Post Approval Study is to report the proportion of patients surviving to 30 days post CentriMag support or to hospital discharge, whichever is longer. For subjects who do not recover and are bridged to a heart transplant or a long-term assist device, the primary endpoint …

anesthesia
  • 0 views
  • 15 Jul, 2022
  • 11 locations