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Found 540 clinical trials
Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Sinusitis Without the Presence of Nasal Polyps

This is a 24-week randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the efficacy and safety of intranasal administration of 186 and 372 g twice daily (BID) of OPN-375 in subjects with chronic sinusitis (CS) without nasal polyps

facial pain
ct scan
nasal polyp
  • 20 Jun, 2021
  • 82 locations
Safety Tolerability and Efficacy of Rapid Optimization Helped by NT-proBNP testinG of Heart Failure Therapies

STRONG-HF is a multicenter, randomized, parallel group study designed to evaluate the efficacy and safety of up-titration of standard oral heart failure medications during hospitalization for acute heart failure. Patients admitted for acute heart failure will be randomized within 2 days before discharge to either usual care or intensification of …

pulmonary congestion
  • 18 Feb, 2021
  • 158 locations
Heart Failure Events Reduction With Remote Monitoring and eHealth Support Investigator Initiated Trial

The primary objective of the study is to evaluate the efficacy of a telemedicine-based follow-up strategy compared with usual care in the management of patients with chronic heart failure (HF) at high risk of clinical events.

heart failure
chronic heart failure
ejection fraction
  • 25 Jan, 2021
  • 1 location
Comparison of Outcomes and Access to Care for Heart Failure Trial

Heart failure is a condition where the heart pump does not function normally causing the lungs to become congested. The primary symptom of heart failure is shortness of breath, and this often leads to patients visiting the emergency department for care. Decision-making in the emergency department is a high-stakes situation, …

  • 19 Feb, 2021
  • 1 location
A Multicenter Trial of a Shared DECision Support Intervention for Patients Offered Implantable Cardioverter-DEfibrillators

The investigators goal is to assess real-world effectiveness of patient decision aids (PtDA) for high-risk decisions using the implantable cardioverter-defibrillator (ICD) as a model.

implantable cardioverter-defibrillators
  • 28 Jan, 2021
  • 1 location
Efficacy Safety and Cost of Remote Monitoring of Patients With Cardiac Resynchronization Therapy

The primary objective is to determine whether comprehensive remote follow-up in HF patients with CRT will reduce the combined endpoint of all-cause mortality or worsening heart failure hospitalizations, whichever comes first, when compared to basic remote monitoring, over a 27-month follow-up.

heart failure
cardiac resynchronization therapy
  • 25 Jan, 2021
  • 1 location
Early or Non-revoked in Hospital-day in Patients With Acute Heart Failure

Heart failure is one of the major causes of hospitalization in Brazil and worldwide. Recent studies attempt to identify readmission and prognostic markers at the time of discharge from these patients. The reassessment and possibility of early therapeutic adjustment may be relevant in this context. Therefore, the prospective and randomized …

chest x-ray
pulmonary congestion
  • 22 Jan, 2021
  • 2 locations
Evaluate the Effectiveness of Self-care Multifaceted Strategy in Heart Failure Patients

Study Design: A randomized, multicenter, national, phase II clinical trial aimed at evaluating the effectiveness of self-care promotion using a multifaceted strategy based on sending text messages(SMS)to patients with heart failure. Methodological quality: Central randomization with allocation concealment; Decision committee for blind outcome assessment; Intention-to-treat analysis

  • 23 Jan, 2021
  • 1 location
Evaluation of Post-operative Nurse-based Heart Failure Care in Non-cardiac Surgery

Patients with heart failure NYHA >= II receiving non-emergent non-cardiac in-patient surgery will be randomized to receive either standard post-operative care (surgeon has to ask actively for specialist cardiological support) or a nurse-based heart failure management (nurses provide week-day support every day after surgery, if needed together with a heart …

  • 24 Jan, 2021
  • 2 locations
Medico-economic Evaluation of Therapeutic Adaptation Guided by the Soluble Suppression of Tumorigenicity 2 (sST-2) Biomarker in the Management of Patients With Acute Heart Failure

Management of patients with heart Failure remains a major health concern because of the high rate of rehospitalization, mortality and induced-cost. Biomarkers could help to guide the management of patients with heart failure (HF). Soluble suppression of tumorigenicity 2 (sST2) appears as a promising biomarker. As a working hypothesis, we …

  • 14 May, 2021
  • 2 locations