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Found 540 clinical trials
Nitrate Effect on Exercise Capacitance

The investigators will investigate the safety and preliminary efficacy of ISDN therapy to reduce venous congestion and improve exercise tolerance in children and adults after the Fontan

  • 05 Feb, 2021
  • 1 location
Impella CP With VA ECMO for Cardiogenic Shock

congestion, which can derail clinical improvement and hamper cardiac recovery. Indeed, percutaneous VA-ECMO increases LV afterload due to the retrograde blood flow, and because of the lack of venting, there

pulmonary congestion
heart transplantation
myocardial infarction
  • 11 Apr, 2021
  • 1 location
LVAD Versus GDMT in Ambulatory Advanced Heart Failure Patients

signs of congestion or low cardiac output. Left ventricular assist devices (LVADs) have been used in patients with heart failure with reduced ejection fraction for almost 20 years either as an

  • 10 Mar, 2021
  • 1 location
OPN-375 Efficacy and Safety in Adolescents With Bilateral Nasal Polyps

This is a 16-Week Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter Study Evaluating the Efficacy and Safety of OPN-375 186 g Twice a Day (BID) in Adolescents with Bilateral Nasal Polyps followed by a 12-Week Open-Label Treatment Phase. The total planned number of subjects is approximately 120 adolescents (12-17 years of …

  • 03 Feb, 2021
  • 30 locations
Mechanisms of Right Ventricular Adaptation in Patients With Heart Failure With Preserved Ejection Fraction

Biventricular PV-loop studies and advanced imaging to assess left-to-right ventricular interaction in HFpEF: In a group of 30 HFpEF patients with clinical indication for LH/RH catheter investigation, we will perform biventricular PV loop assessment in combination with extensive imaging (MRI, echo) for in-depth analysis of left-to-right ventricular interaction in the …

ejection fraction
heart failure with preserved ejection fraction
medical therapy
  • 25 Jan, 2021
  • 2 locations
Effect of Modified Kinesio Taping Technique on Morbidity After Impacted Third Molar

Removal of impacted lower third molar is considered as the most common surgical procedure carried out in the oral and maxillofacial Clinics. The surgical removal of the impacted mandibular third molar is usually associated with pain, swelling and inability to open the mouth. Those symptoms reach the maximum intensity between …

  • 28 May, 2021
  • 1 location
Adrecizumab Dose Escalation Safety and Tolerability Evaluation (ADESTE)

This is an open, standard therapy controlled clinical trial using a single intravenous infusion of HAM8101 (Adrecizumab) in patients hospitalized for AHF. This study will serve as a safety trial for HAM8101 (Adrecizumab) in AHF, using a dose escalating design. Acute Heart Failure (AHF), both as deterioration of chronic stable …

  • 17 Mar, 2021
  • 2 locations
Treatment of Lymphedema: Application of the Kinesio Taping

There are 2 parts to this study. First part: - Reliability of water displacement, circumference, tonometer. - Effect of taping: lifting effect measured with sonography - Effect of taping: peripheral circulation measured with DRT4 Second part: - Effects of different intervention models including decongestive lymphatic therapy (DLT) and modified DLT

breast cancer lymphedema
breast cancer
decongestive lymphatic therapy
female breast
  • 07 Nov, 2020
  • 1 location
Exercise Training in Patients With Cardioverter-Defibrillators

Exercise therapy has proven to be an effective additive therapy in patients with cardiovascular diseases. The prognostic value of physical activity is well established in patients with congestive heart failure. Therefore the investigators assumed that the population of patients with implantable cardioverter-defibrillators (ICD) with impaired left ventricular function may also …

ventricular arrhythmia
implantable cardioverter-defibrillators
left ventricular dysfunction
heart failure
  • 07 Nov, 2020
  • 1 location
Spanish Randomized Clinical Trial to Compare Levosimendan Versus Placebo in Postoperative Cardiac Surgery (SPARTANS)

Low cardiac output Syndrome (LCOS) is a complication that appears in approximately 20% of cardiac surgeries with extracorporeal circulation. LCOS is associated with increased mortality, delayed recovery and prolonged hospital stay. The Spanish Randomized Clinical Trial on Levosimendan (brand name: Sindax) (SPARTANS) aims to demonstrate the effectiveness of the preoperative …

  • 25 Jan, 2021
  • 8 locations