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Found 497 clinical trials
Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip

This is an investigator initiated, prospective study to demonstrate the safety and feasibility of implantation of the V-Wave Interatrial Shunt System (herein called the "V-Wave Shunt" in patients immediately following percutaneous mitral valve repair using the MitraClip system.

  • 24 Apr, 2022
  • 1 location
Argipressin's Influence on Blood Loss and Inflammatory Response During Hepatic Resection

Infusion of Argipressin during hepatic resection surgery reduces blood loss. It may reduce transfusion requirements, and mitigate the perioperative inflammatory response compared to placebo. Subjects will be randomized to infusion of Argipressin or placebo during surgery. Blood loss, transfusion requirements, inflammatory markers and markers of renal- intestinaland cardiac injury will …

  • 01 May, 2022
  • 1 location
Landiolol for Rate Control in Decompensated Heart Failure Due to Atrial Fibrillation

The study will include patients with acute heart failure with reduced left ventricular ejection fraction (<40%) triggered by atrial fibrillation (AF) with a heart rate of >130/min. Patients in cardiogenic shock, critical state, or patients requiring emergent electric cardioversion during the first 2 hours will be excluded. The patients will …

  • 29 Jan, 2021
  • 1 location
Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome

To perform an receiver operating characteristic (ROC) analysis, define a threshold and quantify the sensitivity and specificity of US SWE for risk stratification of patients into three categories as defined by the European Bone Marrow Transplant (EBMT) adult and pediatric criteria: no sinusoidal obstruction syndrome (SOS), mild to moderate SOS, …

conditioning regimen
  • 10 Feb, 2022
  • 1 location
Prospective Randomized Study Comparing ePTFE Versus Dacron Graft for Anterior Sector Venous Drainage in Right Lobe Living Donor Liver Transplantation

Living donor liver transplantation (LDLT) using the right lobe (RL) has created a significant increase in graft supply worldwide. However, it is a technically demanding procedure particularly because of the unique functional anatomic characteristics of hepatic venous drainage [1].

  • 27 Jan, 2021
  • 1 location
Trendelenburg as a First-line Intervention in Critically Ill, Sedated, Invasively Mechanically Ventilated, Hypotensive Patients (Trend)

A pilot randomized controlled trial to evaluate the efficacy and safety of Trendelenburg position in critically ill patients with hypotension, mainly patients with septic shock and post operative vasoplegia. The main aim is to assess whether Trendelenburg position can improve organ function through a reduction in the need of fluid …

  • 24 Mar, 2022
Effect of Dupilumab on Aspirin Intolerance

To test the efficacy of dupilumab in patients with AERD regarding the intolerance to salicylic acid after 6 months. This will be evaluated by oral drug provocation testing with low dose salicylic acid after 6 months of dupilumab treatment. Hypothesis After 6 months of therapy, patients will tolerate aspirin dose …

Accepts healthy volunteers
  • 18 Apr, 2022
  • 1 location
Nasal Suction in Infants With Bronchiolitis Using a NoseFrida vs. Bulb Syringe

This research study will evaluate the difference in effectiveness of nasal suction between two different suction devices (NoseFrida and bulb syringe) in infants that have bronchiolitis. Bronchiolitis (a virus infection that goes into the lungs, which subsequently causes difficulty breathing, difficulty sleeping, and difficulty eating and drinking in children) is …

  • 23 Mar, 2022
  • 1 location
Home BIA Management System in Patients With Heart Failure

This study is a prospective, multi-center, open label, randomized clinical trial conducted in the republic of Korea. The objective of this study is to evaluate the efficacy and safety of the treatment using home bioelectrical impedance analysis (BIA) and linked application system in patients with heart failure (HF).

loop diuretic
  • 26 Mar, 2022
  • 2 locations
Training in HFpEF-PH (TRAIN HFpEF)

Exercise interventions alone or as a component of a comprehensive cardiac rehabilitation program for patients with heart failure (HFrEF and HFpEF) have already shown to reduce the risk of hospitalisations due to HF and improved exercise capacity and health-related quality of life (Sagar et al. Open Heart 2015; Edelmann et …

  • 27 Jul, 2022
  • 1 location