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Found 6 clinical trials
A Study of Mavorixafor in Participants With Severe Congenital Neutropenia and Chronic Neutropenia Disorders

This Phase 1b study will determine the safety and tolerability of mavorixafor in participants with severe chronic idiopathic neutropenia (CIN) and selected congenital neutropenia disorders. The

  • 0 views
  • 29 Jan, 2021
  • 6 locations
Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies

This is a study to collect the outcomes of stem cell transplantation for patients with hematologic diseases other than cancer.

anti-thymocyte globulin
thalassemia
cancer
fludarabine
sickle cell anemia
  • 99 views
  • 26 Jan, 2021
  • 1 location
Fludarabine Phosphate Cyclophosphamide Total Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

This phase II trial studies how well fludarabine phosphate, cyclophosphamide, total body irradiation, and donor stem cell transplant work in treating patients with blood cancer. Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the …

glanzmann's thrombasthenia
bone marrow failure
lymphoproliferative disease
waldenstrom's macroglobulinemia
bone marrow failure syndromes
  • 134 views
  • 24 Jan, 2021
  • 1 location
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS

Background WHIMS (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis Syndrome) is caused by various genetic changes that increase the activity of the chemokine receptor, CXCR4. Excessive function of this receptor causes mature neutrophils (part of the white blood cells) to be retained within the bone marrow rather than being released to the …

cancer
aspermatogenic sterility
immunodeficiency
human papillomavirus
AIDS
  • 67 views
  • 21 Apr, 2021
  • 1 location
Investigation of the Genetics of Hematologic Diseases

The purpose of this study is to collect and store samples and health information for current and future research to learn more about the causes and treatment of blood diseases. This is not a therapeutic or diagnostic protocol for clinical purposes. Blood and bone marrow as well as health information …

hematologic disorder
sickle cell anemia
sickle cell disease
hydroxyurea
blood disorder
  • 94 views
  • 24 Jan, 2021
  • 1 location
Cancer in Inherited Bone Marrow Failure Syndromes

thrombocytopenia: early onset thrombocytopenia. Thrombocytopenia absent radii: absent radii; early onset thrombocytopenia. Severe Congenital Neutropenia: neutropenia, pyogenic infections, bone marrow

bone marrow failure syndromes
shwachman-diamond syndrome
fanca
cancer
synostosis
  • 43 views
  • 02 Apr, 2021
  • 1 location