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Found 173 clinical trials
Cladribine Dose Escalation in Conditioning Regimen Prior to Allo-HSCT for Refractory Acute Leukemia and Myelodysplastic Syndromes

The investigators focused on patients with refractory acute leukemia or MDS and designed a phase 1 trial of escalated cladribine doses in the Cla-Flu-Bu RTC regimen using PK-guided myeloablative busulfan doses. This scheme allows combining different optimization of RTC experienced over years (Flu-Bu RTC, PK-guided myeloablative busulfan doses, a second …

fludarabine
busulfan
acute leukemia
transplant conditioning
myelodysplastic syndromes
  • 8 views
  • 22 Jan, 2021
  • 1 location
Gene Modified Immune Cells (IL13Ralpha2 CAR T Cells) After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma

This phase I trial studies the side effects and best dose of modified immune cells (IL13Ralpha2 CAR T cells) after a chemotherapy conditioning regimen for the treatment of patients with stage

advanced melanoma
absolute neutrophil count
metastatic melanoma
metastasis
cyclophosphamide
  • 2 views
  • 27 Jan, 2021
  • 2 locations
Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

This phase II trial studies how well total marrow and lymphoid irradiation works as a conditioning regimen before hematopoietic cell transplantation in patients with myelodysplastic syndrome or

lymphoid leukemia
fludarabine
transplant conditioning
granulocyte colony stimulating factor
gilbert's syndrome
  • 2 views
  • 26 Jan, 2021
  • 1 location
A Study on the Uterus Ovarian and Reproductive Functions According to Conditioning Regimen and Pubertal Status at the Time of Stem Cell Transplantation in a Leukemia Pediatric Population

hematopoietic stem cell transplantation (HSCT) for CAL. The investigator's objective is to correlate uterus and ovarian function to the conditioning regimen received before HSCT (total body irradiation (TBI) or

busulfan
total body irradiation
acute leukemia
melphalan
cyclophosphamide
  • 18 views
  • 22 Jan, 2021
  • 1 location
Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer

cells (PBSC) after a myeloablative conditioning regimen to treat patients with cancer that has spread to other parts of the body. The conditioning chemotherapy makes room in the patient?s bone marrow

busulfan
metastatic cancer
solid tumour
metastasis
cancer chemotherapy
  • 7 views
  • 18 Feb, 2021
  • 1 location
Feasibility and Efficacy Study of Conditioning Regimen for Allogeneic Hematopoietic Cell Transplantation (HCT) With Fludarabine Busulfan and Total Body Irradiation (TBI)

The purpose of this study is to evaluate the OS, RFS, and TRM after HCT with low-dose total body irradiation, fludarabine, and busulfan conditioning.

fludarabine
busulfan
total body irradiation
cell transplantation
transplant conditioning
  • 36 views
  • 07 Nov, 2020
  • 1 location
G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for RAEB-1 REAB-2 and AML Secondary to MDS Undergoing Allo-HSCT

Allo-HSCT is the most effective way to cure MDS and AML secondary to MDS. At present, the best conditioning regimen for MDS and AML secondary to MDS undergoing allo-HSCT remains in discussion

  • 0 views
  • 29 Jan, 2021
  • 1 location
JSP191 Antibody Targeting Conditioning in SCID Patients

A Phase 1 study to evaluate the safety and tolerability of an antibody conditioning regimen, known as JSP191, in patients with Severe Combined Immune Deficiency undergoing blood stem cell

monoclonal antibodies
primary immunodeficiency
cell transplantation
transplant conditioning
undernutrition
  • 3 views
  • 28 Jan, 2021
  • 6 locations
Stem Cell Transplant in Patients With Severe Sickle Cell Disease

-myeloablative conditioning regimen (Alemtuzumab).

transplant conditioning
sickle cell trait
acute chest syndrome
sirolimus
iron
  • 30 views
  • 24 Jan, 2021
  • 1 location
Ruxolitinib and Decitabine for High Risk Hematological Malignancies

The purpose of this study is to determine the efficacy and safety of Ruxolitinib and Decitabine intensified Conditioning Regimen in Patients with High Risk hematological malignancies undergoing

  • 0 views
  • 25 Jan, 2021
  • 1 location