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Found 167 clinical trials
Post Transplant High-Dose Cy as GvHD Prophylaxis in 1 HLA Mismatched Unrelated HSCT for Myeloid Malignancies

The experimental treatment consists in the application of a therapeutic strategy with post Transplant High-Dose Cyclophosphamide as GvHD Prophylaxis in Patients Receiving 1-Antigen/Allele HLA Mismatched (7/8 matched) Unrelated Hemopoietic Stem Cell Transplantation for Myeloid Malignancies.

  • 0 views
  • 26 Mar, 2021
  • 33 locations
Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

morphological remission (CR, less than 5% bone marrow blasts, no blasts in cerebrospinal fluid, no other extramedullary leukemia), who have an indication for HSCT with a myeloablative conditioning regimen.

remission
thymoglobulin
b-cell acute lymphoblastic leukemia
cancer
thiotepa
  • 389 views
  • 25 Jan, 2021
  • 158 locations
A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT

Treatment options for older adults with Acute Myeloid Leukaemia (AML) and Myelodysplasia (MDS) are limited. Although stem cell transplantation remains one of the most effective treatments it is associated with severe side effects which have until recently prevented its use in older adults. In the last decade the use of …

myelodysplasia
remission
secondary acute myeloid leukemia
hla-a
fludarabine
  • 0 views
  • 24 Jan, 2021
  • 1 location
A Trial to Evaluate the Safety and Efficacy of oNKord in Subjects With Acute Myeloid Leukemia

WiNK is a Phase I/IIa trial to evaluate the safety and efficacy of oNKord in 33 adults with acute myeloid leukemia (AML) who are in morphologic complete remission with residual measurable disease and with no strong indication for hematopoietic stem cell transplantation.

transplant conditioning
consolidation chemotherapies
hematologic disorder
remission
fludarabine
  • 0 views
  • 24 May, 2021
  • 8 locations
A Study of JNJ-68284528 a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma

The purpose of this study is to evaluate the overall minimal residual disease (MRD) negative rate of participants who receive JNJ-68284528.

immunomodulatory imide drug
measurable disease
immunoglobulins
kappa light chain
lenalidomide
  • 15 views
  • 31 Jul, 2021
  • 42 locations
Evaluating QTc PK Safety of Gemtuzumab Ozogamicin (GO) in Patients With CD33+ R/R AML

This is a single-arm, open-label, Phase 4 study evaluating the effect of GO on the QTc, pharmacokinetics, safety, and immunogenicity of GO as a single-agent monotherapy in adult and pediatric patients with relapsed or refractory CD33-positive AML.

  • 4 views
  • 01 Aug, 2021
  • 41 locations
RCT Comparing Autologous Hematopoietic Stem Cell Transplantation Versus Alemtuzumab in MS

This study is a randomized multicentre, multinational, treatment interventional study of RRMS patients with breakthrough inflammatory disease activity in spite of ongoing standard immunomodulatory medication. The study has two treatment arms; arm A: HSCT (hematopoietic stem cell transplantation) and arm B: alemtuzumab, a registered immunomodulatory treatment of RRMS. A pre-planned …

fingolimod
dimethyl fumarate
disease or disorder
MRI
corticosteroids
  • 35 views
  • 19 Feb, 2021
  • 9 locations
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

This phase III trial compares standard chemotherapy to therapy with CPX-351 and/or gilteritinib for patients with newly diagnosed acute myeloid leukemia with or without FLT3 mutations. Drugs used in chemotherapy, such as daunorubicin, cytarabine, and gemtuzumab ozogamicin, work in different ways to stop the growth of cancer cells, either by …

cytarabine/daunorubicin
anthracyclines
gemtuzumab
cancer
mitoxantrone
  • 5 views
  • 30 Jul, 2021
  • 93 locations
Haplo vs. URD in AML

This study compares haplo-identical family donor stem cell transplantation (haplo SCT) to matched unrelated donor transplantation (URD SCT) in adult patients with acute myeloid leukemia (AML) with the hypothesis that haplo SCT is as good as URD SCT. Background A haplo-identical family donor is a relative sharing 50% of the …

cell transplantation
hla-a
cyclophosphamide
graft versus host disease
busulfan
  • 4 views
  • 23 Jan, 2021
  • 14 locations
Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation

In this study, the investigators test 2 dose levels of thiotepa (5 mg/kg and 10 mg/kg) added to the backbone of targeted reduced dose IV busulfan, fludarabine and rabbit anti-thymocyte globulin (rATG) to determine the minimum effective dose required for reliable engraftment for subjects undergoing hematopoietic stem cell transplantation for …

antithymocyte globulin
hemophagocytic lymphohistiocytosis
shortening fraction
follicle-stimulating hormone
fludarabine
  • 176 views
  • 19 Jul, 2021
  • 1 location