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Found 172 clinical trials
Prevention of Oral Mucositis Using Photobiomodulation Therapy

Oral mucositis is a significant and common toxicity experienced by patients who receive high-dose chemotherapy as a preparatory regimen for a hematopoietic cell transplant (HCT). Furthermore, oral mucositis has been reported as the single most debilitating side effect reported by patients undergoing HCT. The incidence of HCT mucositis among adults …

high dose chemotherapy
mucositis
  • 3 views
  • 17 Feb, 2021
  • 1 location
Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

morphological remission (CR, less than 5% bone marrow blasts, no blasts in cerebrospinal fluid, no other extramedullary leukemia), who have an indication for HSCT with a myeloablative conditioning regimen.

cell transplantation
thymoglobulin
remission
fludarabine
cyclophosphamide
  • 389 views
  • 25 Jan, 2021
  • 158 locations
A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT

Treatment options for older adults with Acute Myeloid Leukaemia (AML) and Myelodysplasia (MDS) are limited. Although stem cell transplantation remains one of the most effective treatments it is associated with severe side effects which have until recently prevented its use in older adults. In the last decade the use of …

myelodysplasia
cell transplantation
secondary acute myeloid leukemia
hla-a
remission
  • 0 views
  • 24 Jan, 2021
  • 1 location
A Trial to Evaluate the Safety and Efficacy of oNKord in Subjects With Acute Myeloid Leukemia

WiNK is a Phase I/IIa trial to evaluate the safety and efficacy of oNKord in 33 adults with acute myeloid leukemia (AML) who are in complete morphologic remission with residual measurable disease and with no strong indication for hematopoietic stem cell transplantation.

  • 0 views
  • 28 Jan, 2021
  • 8 locations
A Study of JNJ-68284528 a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma

The purpose of this study is to evaluate the overall minimal residual disease (MRD) negative rate of participants who receive JNJ-68284528.

cell transplantation
measurable disease
daratumumab
dexamethasone
immunomodulatory imide drug
  • 15 views
  • 05 Feb, 2021
  • 42 locations
Evaluating QTc PK Safety of Gemtuzumab Ozogamicin (GO) in Patients With CD33+ R/R AML

This is a single-arm, open-label, Phase 4 study evaluating the effect of GO on the QTc, pharmacokinetics, safety, and immunogenicity of GO as a single-agent monotherapy in adult and pediatric patients with relapsed or refractory CD33-positive AML.

  • 4 views
  • 01 Feb, 2021
  • 41 locations
RCT Comparing Autologous Hematopoietic Stem Cell Transplantation Versus Alemtuzumab in MS

This study is a randomized multicentre, multinational, treatment interventional study of RRMS patients with breakthrough inflammatory disease activity in spite of ongoing standard immunomodulatory medication. The study has two treatment arms; arm A: HSCT (hematopoietic stem cell transplantation) and arm B: alemtuzumab, a registered immunomodulatory treatment of RRMS. A pre-planned …

cyclophosphamide
fingolimod
glatiramer acetate
interferon
alemtuzumab
  • 35 views
  • 19 Feb, 2021
  • 9 locations
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

This phase III trial compares standard chemotherapy to therapy with CPX-351 and/or gilteritinib for patients with newly diagnosed acute myeloid leukemia with or without FLT3 mutations. Drugs used in chemotherapy, such as daunorubicin, cytarabine, and gemtuzumab ozogamicin, work in different ways to stop the growth of cancer cells, either by …

gemtuzumab
cell transplantation
cytarabine
methotrexate
cytarabine/daunorubicin
  • 5 views
  • 24 Feb, 2021
  • 67 locations
Haplo vs. URD in AML

This study compares haplo-identical family donor stem cell transplantation (haplo SCT) to matched unrelated donor transplantation (URD SCT) in adult patients with acute myeloid leukemia (AML) with the hypothesis that haplo SCT is as good as URD SCT. Background A haplo-identical family donor is a relative sharing 50% of the …

graft versus host disease
cell transplantation
mycophenolate mofetil
hla-a
fludarabine
  • 4 views
  • 23 Jan, 2021
  • 14 locations
BUCYE Conditioning Regimen for PCNSL Undergoing Auto-HSCT

The purpose of this study is to evaluate the safety and efficacy of BUCYE conditioning regimens in primary central nervous system lymphoma undergoing autologous hematopoietic stem cell transplantation.

nervous
etoposide
cyclophosphamide
  • 5 views
  • 22 Jan, 2021