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Found 61 clinical trials
Sequential or Concurrent Chemoradiotherapy in Patients With Locoregionally Advanced NPC

The purpose of this study is to compare the efficacy and safety of sequential chemoradiotherapy (induction chemotherapy + intensity-modulated radiotherapy +adjuvant chemotherapy) with induction chemotherapy plus concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma (NPC), in order to confirm the value of sequential chemoradiotherapy in NPC patients.

nasopharyngeal carcinoma
chemotherapy regimen
intensity-modulated radiation therapy
carcinoma
neutrophil count
  • 0 views
  • 12 Mar, 2022
  • 1 location
De-escalation of Adjuvant Radio (Chemo) Therapy for HPV-positive Head-neck Squamous Cell Carcinomas (DELPHI)

In patients with squamous cell carcinoma of the oral cavity, the oropharynx and larynx with local advanced tumors (pathologic stage T3 = pT3) and or lymph node involvement (pN+) postoperative radio - or radiochemotherapy is the standard of care. Postoperative radiochemotherapy is indicated in patients with multiple lymph node metastasis, …

  • 0 views
  • 18 Sep, 2023
  • 8 locations
Postoperative Concurrent Chemoradiotherapy Combined With Endostar for High-risk Early Stage Cervical Cancer (ChESS)

To assess the efficacy and safety of postoperative concurrent chemoradiotherapy combined with recombinant human endostatin (Endostar) in patients with high-risk early stage cervical cancer.

adenocarcinoma
cervical cancer stage
carcinoma
neutrophil count
chemoradiotherapy
  • 9 views
  • 12 Feb, 2022
  • 1 location
Atezolizumab Plus Induction Chemotherapy Plus CT-radiotherapy. (APOLO) (APOLO)

Open-label, non-randomized, phase II multi-centre controlled clinical trial. 51 non-resectable stage IIIA-IIIB non-small cell lung cancer patients will be enrolled in this trial to evaluate the efficacy of the treatment (Atezolizumab + Induction chemotherapy (CT) + CT-Radiotherapy) in terms of the Progression Free Survival at 12 months

adjuvant chemotherapy
paclitaxel
atezolizumab
carboplatin
platelet count
  • 0 views
  • 15 Jun, 2022
  • 22 locations
Addressing Taste Dysfunction With Miraculin in Head and Neck Cancer Patients Receiving Radiation Therapy

Patients diagnosed with head and neck cancer who receive radiation therapy with and without chemotherapy develop altered sense of taste due to treatment effect, which typically arises in the second week of radiation therapy and progresses throughout the course of treatment. While some symptoms such as pain, mucositis, and xerostomia …

neck dissection
concurrent chemotherapy
carcinoma
mucositis
squamous cell carcinoma
  • 0 views
  • 15 Jul, 2022
  • 1 location
PROTECT: On-line Adaptive Proton Therapy for Cervical Cancer (PROTECT)

This prospective, multicenter, nonrandomized phase-II-trial investigates in clinical practice the differences between intensity modulated proton therapy (IMPT) and standard intensity-modulated radiation therapy (IMRT) or volumetric-modulated arc therapy (VMAT) in the effects on dose-volume parameters and treatment-related morbidity for women with locally advanced cervical cancer undergoing chemoradiation.

adenocarcinoma
pet/ct scan
carcinoma
brachytherapy
treatment regimen
  • 0 views
  • 16 Jun, 2022
  • 1 location
Durvalumab, an Anti-PDLI Antibody, and Tremelimumab, an Anti-CTLA4 Antibody, and Chemoradiation Before Surgery for Esophageal Cancer

The purpose of this study is to test the safety of adding a new drug, durvalumab (also called MEDI4736), to chemoradiation with either FOLFOX/Capeox or carboplatin and paclitaxel, following initial chemotherapy with FOLFOX. The investigators want to find out what effects, good and/or bad, this combination has on the patient …

paclitaxel
carboplatin
chemoradiotherapy
esophagectomy
hysterectomy
  • 52 views
  • 04 Jun, 2022
  • 7 locations
Concurrent Radiochemotherapy Plus Anlotinib for Locally Advanced Cervical Cancer

To observe the efficacy and safety of hydrochloride anlotinib combined with concurrent radiochemotherapy for patients with FIGO stage IB3 and IIA2-IVA cervical cancer. Patient characteristics, image and genetic information of tumor, microbial sample of tumor microenvironment and biomarker in the blood sample will be collected and analysis by multi-omics and …

cervical biopsy
adenocarcinoma
aptt
chemotherapy regimen
carcinoma
  • 0 views
  • 28 May, 2022
  • 1 location
Accelerated Hypofractionated vs. Conventionally Fractionated Concurrent CRT for LS-SCLC

This protocol is a phase III randomized controlled trial (RCT) evaluating the efficacy of induction chemotherapy followed by accelerated hypofractionated vs. conventionally fractionated concurrent chemo-radiotherapy for limited-stage small cell lung cancer.

limited stage small cell lung cancer
cancer chemotherapy
carboplatin
  • 29 views
  • 08 May, 2021
  • 1 location
The Optimization of Antiemetic Regimen for C-RINV in LA-HNSCCs

This study sought to investigate the efficacy and safety of a three-drug combination antiemetic regimen of olanzapine combined with aprepitant and palonosetron for the prevention of chemoradiotherapy-induced nausea and vomiting in locally advanced head and neck squamous cell carcinoma.

aprepitant
carcinoma
palonosetron
nausea
cavity
  • 0 views
  • 21 Mar, 2022