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Found 61 clinical trials
Clinico-biological Data Collection Study of Metastatic Breast Cancer (EPICURE_SEIN)

RATIONALE : Currently, the mechanisms associated with the response or resistance to treatment are poorly understood and are multifactorial. These mechanisms involve clinical and biological factors associated with the host and the tumor and possibly the patient's psycho-social environment. PURPOSE : This trial will assess the use of a prospective …

erbb2
progesterone receptor
immunostimulant
stage iv breast cancer
metastasis
  • 1 views
  • 09 Feb, 2022
  • 2 locations
Hyperpolarized 13C MR Imaging of Lactate in Patients With Locally Advanced Cervical Cancer (LACC) Cervical Cancer

The purpose of this study is to image tumour lactate in study participants with locally advanced cervical cancer. Our hypothesis is that lactate content in cervical tumours, as measured by hyperpolarized 13C Magnetic Resonance (MR) imaging, will correlate with diffusion-weighted MRI and 18FDG-PET (fluorodeoxyglucose-positron emission tomography). Furthermore, lactate imaging will …

x-rays
cancer
fludeoxyglucose f 18
carcinoma
adenocarcinoma
  • 11 views
  • 22 Nov, 2021
  • 1 location
Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress (PRMRP-FPA2)

The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. Research suggests that ankle arthritis develops after ankle fracture, in part, due to elevated forces on the cartilage. It is expected that carbon fiber braces can be designed to reduce forces in the …

Accepts healthy volunteers
arthritis
ankle fracture
  • 0 views
  • 22 Mar, 2022
  • 1 location
MV-NIS or Investigator's Choice Chemotherapy in Treating Patients With Ovarian, Fallopian, or Peritoneal Cancer

This randomized phase II trial studies how well oncolytic measles virus encoding thyroidal sodium iodide symporter (MV-NIS) compared to investigator's choice chemotherapy works in treating patients with ovarian, fallopian, or peritoneal cancer. Measles virus, which has been changed in a certain way, may be able to kill tumor cells without …

topotecan
ejection fraction
neutrophil count
carboplatin
doxorubicin
  • 41 views
  • 24 Apr, 2022
  • 3 locations
Multiple Myeloma Trial of Orally Administered Salmonella Based Survivin Vaccine

Multiple myeloma patients will receive a cancer vaccine, called TXSVN that has been derived from the bacteria Salmonella. TXSVN is a weakened form of a live vaccine strain of the Salmonella bacteria (also known as the CVD908ssb strain) that has been genetically modified in the laboratory to produce a protein …

cancer
  • 0 views
  • 28 Oct, 2021
  • 1 location
Efficacy of PRGF Supplementation After TMJ Arthrocentesis in Patients With TMJ Osteoarthritis

Temporomandibular joint (TMJ) osteoarthritis (OA) affects articulating tissues secondary to inflammation resulting in intracapsular pain. This prospective, double-blind randomized clinical trial will evaluate the relative efficacy of TMJ arthrocentesis with a supplementation of platelet-rich growth factors (PRGF) compared to TMJ arthrocentesis with a steroid supplementation (a known effective therapy) for …

NSAID
arthralgia
  • 0 views
  • 21 Mar, 2022
  • 1 location
A Phase II Study of Cyberknife Radiosurgery for Renal Cell Carcinoma

CyberKnife Based Radiosurgery is a way to deliver large doses of radiation very accurately to a tumor. The ability of this technology to minimize radiation dose to organs adjacent to the target tumor allows a high dose to be delivered to the tumor, thus potentially increasing the efficacy of radiation …

cancer
brain metastasis
carcinoma
metastasis
lung cancer
  • 40 views
  • 01 May, 2022
Tumor-Associated Antigen-Specific Cytotoxic T-Lymphocytes for Multiple Myeloma

This study is for patients that have a cancer called Multiple Myeloma, monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SM). MGUS and SM have tumor cells that possess nearly identical properties to the cancer cells seen in patients with multiple myeloma. The investigators would like to target proteins …

cancer
pomalidomide
lenalidomide
tumor cells
measurable disease
  • 18 views
  • 19 Nov, 2021
  • 1 location
Antibiotic Prophylaxis With Routine Ureteral Stent Removal (STENTABX)

This study will be a single-institutional randomized, single-blinded prospectively controlled clinical trial of a single dose of Ciprofloxicin 500mg antibiotic tablet as prophylaxis at the time of office flexible cystoscopy with ureteral stent removal. The control group will be no prophylaxis oral antibiotics.

antibiotic prophylaxis
sulfamethoxazole
nephrolithiasis
trimethoprim
antibiotics
  • 158 views
  • 23 Feb, 2022
  • 1 location
Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers (POLCAGB)

Locally advanced Gall bladders cancers not amenable for curative resection are often treated with chemotherapy alone which is the current standard of care. Randomized trials have shown survival benefit with combination chemotherapy in gallbladder cancers. Gallbladder cancer is not common western world and thus there is lack of evidence regarding …

cancer
gemcitabine/cisplatin
serum bilirubin
gemcitabine
cholecystectomy
  • 38 views
  • 01 Feb, 2022
  • 1 location