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Found 2455 clinical trials
Studies of Inherited Diseases of Metabolism

Diseases of mineral metabolism such as familial multiple endocrine neoplasia type 1 (FMEN1), familial hypocaliuric hypercalcemia (FHH), familial hyperparathyroidism (FH), and pseudohypoparathyroidism (PHP) are known as hereditary abnormalities. Meaning these conditions are passed from parents to their children through genes. These specific conditions result in abnormal levels of calcium in …

genetic counseling
  • 18 Apr, 2021
  • 1 location
Identification of Outcome Relevant Indicators in Routine Data

The availability of electronic documentation systems in patient care means that large amounts of clinical routine data are available from which conclusions can be drawn for improving patient care. Compared to conventional research approaches, a data science-oriented approach offers the possibility of identifying patterns in routine data ("pattern recognition") that …

  • 27 Jan, 2021
  • 2 locations
Cancer Genome Atlas of China:Lung Cancer

Based on 2500 lung cancer tumor tissue samples from about 40 clinical centers in China, the molecular typing of lung cancer in China will be figured out by high throughput sequencing, which will provide the basis for the follow-up research and development of new drugs as well as the guidance …

lung carcinoma
  • 23 Jan, 2021
  • 31 locations
Biomarkers of CASH

The project aims to develop prognostic and diagnostic blood tests for symptomatic brain hemorrhage in patients diagnosed with cavernous angiomas, a critical clinical challenge in a disease affecting more than a million Americans. We further examine whether blood biomarkers can replace or enhance the accuracy of advanced imaging in association …

  • 24 Jan, 2021
  • 2 locations
Therapeutic Option for Hepatitis B and C: a French Cohort

The cohort will integrate clinical, genetic, pharmacogenomics, environmental, biomarkers and behavioral data in a large number of patients and will be a leading equipment for crossdisciplinary and translational research on hepatitis. The cohort will be the main support for estimating the relative effects of treatments and for further cost-effectiveness studies …

hepatitis c antibody
chronic hepatitis
hepatitis b surface antigen
  • 21 Jan, 2021
  • 1 location
Psychosocial Syndemics of Heart Failure

Heart failure (HF) is a common and debilitating chronic disease with a poor prognosis. Many patients with HFhave psychiatric problems such as depression and other medical disorders such as lung or kidney disease.This study will examine the effects that these psychiatric and medical disorders have on HF outcomes.

  • 17 Apr, 2021
  • 1 location
Prognostic Evaluation of Inflammatory Polyarthritis of Recent Onset

Inflammatory joint diseases are major causes of invalidity and morbidity. Rheumatoid arthritis (RA), the most frequent of chronic arthritides, affects close to 1% of the Canadian population. Direct and indirect costs of RA represent close to 1% of the gross national product. Recent evidence suggest that initiation of early (e.g., …

rheumatoid arthritis
  • 12 Mar, 2021
  • 1 location
Outcomes of HIV Infected Individuals After Ten Years on Antiretroviral Treatment

Study Title: Outcomes of HIV infected individuals after ten years on antiretroviral treatment Short Title/Study ID: ALT cohort Protocol Version and Date: Version 1.0 June 2013 Clinical Phase: NA Methodology: Prospective observational study Study Duration: 01 January 2014- 30th June 2025 Study Centre(s): Single centre (Infectious Diseases Institute, Kampala, Uganda) …

antiretroviral agents
  • 21 Jan, 2021
  • 1 location
Evaluation of Patients With Immune Function Abnormalities

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation. This may include inherited conditions, such as X-linked severe combined immunodeficiency (XSCID), chronic granulomatous disease (CGD), and leukocyte adhesion deficiency (LAD), or conditions resulting from outside factors, such as graft-versus-host disease …

  • 05 May, 2021
  • 1 location
Neonatal Screening of Severe Combined Immunodeficiencies

The goal of the proposed research is to observe the prevalence and establish the validity of a newborn screening method for severe combined immunodeficiency (SCID). The assay to be used is developed on the basis of PCR quantification of T-cell receptor excision circles (TRECs) that is absent in SCID patients, …

severe combined immunodeficiency
  • 03 Feb, 2021
  • 1 location