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Found 2372 clinical trials
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A 52-week, phase 3, multicentre, randomised, double blind, efficacy and safety study comparing GSK3196165 with placebo and with tofacitinib, in combination with MTX in participants with moderately to severely active RA who have an inadequate response to MTX.

A 52-week, phase 3, multicentre, randomised, double blind, efficacy and safety study comparing GSK3196165 with placebo and with tofacitinib, in combination with MTX in participants with moderately to severely active RA who have an inadequate response to MTX.  

tofacitinib
  • 55 views
  • 23 Nov, 2020
  • 1 location
featured
Comparative evaluation of the performance and safety of A-CP HA Kit, for the preparation of a combination of platelet-rich plasma and hyaluronic acid, versus hyaluronic acid alone and placebo in patients with knee osteoarthritis

The purpose of this study is to assess the performance and safety of a combination of hyaluronic (HA) and platelet-rich plasma (PRP) in knee injection treatment for use in relieving symptoms in patietns with knee pain. To qualify you must be between ages 50 and 80, have Grade 2 or …

knee pain
hyaluronic acid
  • 109 views
  • 11 Jun, 2020
  • 1 location
featured
A Randomized, Multicenter, Double Blind, Phase 3 Study of Nivolumab, Nivolumab in Combination with Ipilimumab, or Placebo as Maintenance Therapy in Subjects with Extensive-Stage Disease Small Cell Lung Cancer (SCLC) after Completion of Platinum-based First Line Chemotherapy

A Randomized, Multicenter, Double Blind, Phase 3 Study of Nivolumab, Nivolumab in Combination with Ipilimumab, or Placebo as Maintenance Therapy in Subjects with Extensive-Stage Disease Small Cell Lung Cancer (SCLC) after Completion of Platinum-based First Line Chemotherapy

maintenance therapy
lung cancer
cancer chemotherapy
nivolumab
  • 432 views
  • 23 Nov, 2020
  • 1 location
featured
The AIRWISE Study: Assessment In a Real World setting of the effect of Inhaled Steroid-based triple therapy versus the combination of tiotropium and olodaterol on reducing COPD Exacerbations

Patients diagnosed with COPD will be approached and asked to complete Questionnaires. These questionnaires will help guide the sponsor as to what patients thinks which works better, being on triple therapy or combo therapy when dealing with COPD and exacerbations  

  • 54 views
  • 11 Jun, 2020
  • 1 location
featured
A Phase 1b Study of INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors Carcinoma

The purpose of this study is to determine the safety, preliminary evidence of clinical activity, and recommended Phase 2 dose (RP2D) of INCMGA00012 in combination with other agents that may improve the therapeutic efficacy of anti-PD-1 monotherapy.

cancer
solid tumors
  • 25 views
  • 14 Dec, 2020
  • 9 locations
featured
An Open-Label Phase 2 Study of Itacitinib (INCB039110) in Combination With Low-Dose Ruxolitinib or Itacitinib Alone Following Ruxolitinib in Subjects With Myelofibrosis

The purpose of this study is to evaluate the efficacy and safety of itacitinib combined with low-dose ruxolitinib or itacitinib alone in subjects with myelofibrosis.   This is an open-label Phase 2 study with 2 cohorts: Cohort A: Itacitinib plus ruxolitinib  Drug: Itacitinib self-administered orally once daily at the   protocol-defined …

leukemia
myeloproliferative disorders
myelofibrosis
  • 141 views
  • 14 Dec, 2020
  • 11 locations
featured
A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors

The purpose of this open-label nonrandomized Phase 1/2 study is to evaluate INCB001158 in combination with chemotherapy in participants with advanced/metastatic solid tumors.  

cancer
measurable disease
metastatic cancer
solid tumor
solid tumors
  • 38 views
  • 14 Dec, 2020
  • 13 locations
featured
A Phase 1, Open-Label, Dose-Finding Study of INCB050465 in Combination With Investigator Choice of Rituximab, Bendamustine and Rituximab,or Ibrutinib in Participants With Previously Treated B-Cell Lymphoma (CITADEL-112)

The purpose of this study is to evaluate the safety and tolerability of INCB050465 when combined with rituximab, bendamustine and rituximab, or ibrutinib in participants with relapsed or refractory B-cell lymphoma.  

lymphomas
b-cell lymphoma
lymphoma
  • 72 views
  • 14 Dec, 2020
  • 21 locations
featured
Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies

The purpose of this study is to determine the safety, tolerability, and efficacy of INCAGN01876 when given in combination with immune therapies in subjects with advanced or metastatic malignancies.  

metastatic cancer
measurable disease
pd-l1
cancer
  • 91 views
  • 10 Dec, 2020
  • 23 locations
featured
A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy (SAPPHIRE)

This is an open-label, randomized (1:1), multicenter, Phase 3 clinical trial evaluating the safety and efficacy of nivolumab in combination with investigational agent sitravatinib compared to docetaxel in patients with advanced non-squamous NSCLC who have previously experienced radiographic disease progression on or after treatment with platinum-based chemotherapy in combination with …

squamous non-small cell lung cancer
platinum-based chemotherapy
advanced non-squamous non-small cell lung cancer
docetaxel
cancer chemotherapy
  • 199 views
  • 05 Mar, 2021
  • 142 locations