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Found 559 clinical trials
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Anti-angiogenic Agents Plus Anti-PD-1 Antibodies for uHCC

Combination treatment with antiangiogenic agents and anti-programmed cell death protein 1 (PD-1) antibodies have shown high anti-tumor efficacy for patients with unresectable or advanced hepatocellular carcinoma (uHCC). In this single-center cohort study, we are aiming to (1) evaluate the clinical effectiveness in real-world patients, especially for Chinese patients, most of …

tyrosine
cancer
pembrolizumab
  • 0 views
  • 03 Aug, 2021
  • 1 location
None
Towards Neurobiology-based Diagnosis and Treatment of Affective Disorders

The project is a multi-center, prospective cohort study. The study's total targeted enrollment is 400 first-episode patients with major depressive disorder (MDD) and 400 healthy controls.

depressive episode
depressive disorder
depression
depressed mood
duloxetine
  • 17 views
  • 06 Sep, 2021
  • 1 location
None
Long-term Safety Study of Arsenic Trioxide in Newly Diagnosed Low-to-intermediate Risk Acute Promyelocytic Leukemia

The therapeutic advantage of the association of ATRA + Arsenic Trioxide is more favorable and manageable as compared to ATRA + chemotherapy. Nevertheless, at present, there is not enough information on the incidence of long-term side effects. This study, as well as other similar studies conducted around Europe, will focus …

acute promyelocytic leukemia
tretinoin
arsenic
white blood cells
  • 0 views
  • 26 Jan, 2021
  • 18 locations
None
Radiomic Signature as Predictive Marker of Response to Chemoradiation and Durvalumab in Stage III NSCLC.

The introduction of maintenance immunotherapy with the anti PD-L1 inhibitor durvalumab opened a new therapeutic window for stage III NSCLC patients who achieve at least stable disease after chemo-radiation, as shown by the randomized phase 3 PACIFIC study. However, still half of the patients do progress at 12 months (up …

durvalumab
lung cancer
cancer
stage iii non-small cell lung cancer
lung carcinoma
  • 0 views
  • 11 Nov, 2021
  • 1 location
None
Pulmonary Vascular Disease in CF

In this project, the investigators seek to understand the role of endothelial cells in Cystic Fibrosis (CF) lung disease. This objective will be achieved by conducting a cross sectional clinical study to define the morphology of the pulmonary circulation across a range of lung function coupled with a mechanistic study …

solid tumor
fibrosis
  • 0 views
  • 19 Nov, 2021
  • 2 locations
None
Precision Crohn's Disease Management Utilizing Predictive Protein Panels (ENvISION)

Crohn's disease and ulcerative colitis affect about 1.6 to 3 million people in the United States with many of those being young children and adolescents. Physicians need better ways to inform decisions on therapy selection and recognize ongoing intestinal injury while on treatment. The main reason for this research study …

infliximab
ulcerative colitis
luminal
ulceration
faecal calprotectin
  • 27 views
  • 02 Jul, 2021
  • 4 locations
None
Immune Response to Anti-HER2 Therapies in Patients With HER2-Positive Stage I-IV Breast Cancer

This study gathers information from the blood cells and tumor tissue during treatment with anti-HER2 therapies, such as trastuzumab, pertuzumab, lapatinib, or neratinib, in patients with HER2 positive stage I-IV breast cancer who are scheduled to start anti-HER2 therapy. The information gained from this study may help researchers better understand …

adenocarcinoma of the breast
HER2
progesterone
estrogen
trastuzumab
  • 0 views
  • 22 Aug, 2021
  • 1 location
None
Immunogenicity of COVID-19 Vaccine in Patients With Inflammatory Bowel Disease

The overall objective of this proposal is to evaluate the safety and immunogenicity of a COVID-19 vaccine in patients with Inflammatory Bowel Disease (IBD). This will help determine if immunosuppressive regimens impact COVID-19 vaccine response. The investigators will determine if certain groups may need more doses of a vaccine, with …

infliximab
corticosteroids
corticosteroid therapy
ulceration
tumor necrosis factor
  • 0 views
  • 08 Dec, 2021
  • 1 location
None
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection

The purpose of this study is to examine gene expression profiles by DNA microarray in patients who are responders and non-responders to interferon and ribavirin treatment for hepatitis C virus (HCV). Genes involved in inflammation and fibrosis and mediators of the Th-1 lymphocyte response will be looked for. It is …

interferon
mono
chronic hepatitis
fibrosis
ribavirin
  • 47 views
  • 07 Nov, 2020
  • 1 location