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Found 561 clinical trials
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Title: Therapeutic Targets in African-American Youth With Type 2 Diabetes

Background The pill metformin treats diabetes. But it does not work for all youth, especially African-Americans. The injectable Liraglutide treats type 2 diabetes in adults. Researchers want to understand how these drugs work and if they decrease excess sugar made by the liver in youth with type 2 diabetes. Objective …

hypoglycemic agents
metformin
continuous glucose monitoring
sugars
liraglutide
  • 9 views
  • 31 Oct, 2021
  • 2 locations
None
Olaparib and Entinostat in Patients With Recurrent Platinum-Refractory Resistant Ovarian Primary Peritoneal Fallopian Tube Cancers

This phase I/II trial studies the side effects and best dose of olaparib and entinostat and to see how well they work in treating patients with ovarian, primary peritoneal, or fallopian tube cancers that have come back or do not respond to platinum-based chemotherapy. Olaparib and entinostat may stop the …

cancer of the ovary
cancer chemotherapy
recurrent disease
absolute neutrophil count
BRCA2
  • 0 views
  • 24 Jul, 2021
  • 2 locations
None
Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

This phase I/II trial studies the best dose and side effects of peposertib and to see how well it works with avelumab and hypofractionated radiation therapy in treating patients with solid tumors and hepatobiliary malignancies that have spread to other places in the body (advanced/metastatic). Peposertib may stop the growth …

metastasis
glomerular filtration rate
monoclonal antibodies
antibody therapy
anti-cancer agents
  • 129 views
  • 19 Nov, 2021
  • 5 locations
None
Topotecan Plus M6620 (VX-970) vs. Topotecan Alone in People With Relapsed Small-Cell Lung Cancer

Background Small cell cancers are aggressive and grow fast. They can appear in the lungs and in other parts of the body. These tumors often don t respond well to treatment if they come back after chemotherapy. Treatment with two drugs combined may be able to help. Objective To compare …

topotecan
  • 1 views
  • 18 Nov, 2019
  • 1 location
None
ABEMA Alone or in COMBO With MK-6482

This research study will assess whether abemaciclib alone or in combination with MK-6482 are safe and effective in slowing down the growth of clear cell renal cell carcinoma (ccRCC). The names of the study drugs in this investigational combination are: Abemaciclib MK-6482

  • 0 views
  • 08 Apr, 2021
  • 2 locations
None
Clonidine to Prevent Delirium After Electroconvulsive Therapy.

Electroconvulsive therapy (ECT) is a highly effective treatment for some psychiatric disorders like major depressive or bipolar disorder, but may lead to agitation and delirium after the procedure in up to 65% of patients. This can have negative side effects and be dangerous for patient and attending staff. Clonidine, a …

electroconvulsive therapy
  • 0 views
  • 03 Jun, 2021
  • 1 location
None
Nivolumab With Chemotherapy in Pleural Mesothelioma After Surgery

Patients with malignant pleural mesothelioma stage I-III who have undergone cytoreductive surgery with curative intend consisting of extended pleurectomy / decortication (eP/D) with or without hyperthermic intrathoracic chemoperfusion (HITOC) who will receive a maximum treatment duration of 16 cycles (4 cycles of chemotherapy in both arms + 12 cycles maintenance …

nivolumab
carboplatin
pleurectomy
experimental drug
pemetrexed
  • 1 views
  • 25 Feb, 2021
  • 16 locations
None
Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough

This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with interstitial lung disease (ILD)-related cough.

nintedanib
tubal ligation
pirfenidone
interstitial lung disease
azathioprine
  • 0 views
  • 21 Nov, 2021
  • 1 location
None
Cilostazol and Nimodipine Combined Therapy After Aneurysmal Subarachnoid Hemorrhage (aSAH)

The investigators seek to demonstrate that the combined use of cilostazol and nimodipine will significantly decrease the rate of delayed cerebral infarction and cerebral vasospasm after cerebrovascular intervention when compared to nimodipine alone.

  • 2 views
  • 27 Jan, 2021
  • 1 location
None
Combined Therapy of Nivolumab and Adoptive T Cell Therapy in Metastatic Melanoma Patients

To improve the efficacy of immunotherapy for cancer, recent studies focused on specific targets to redirect the immune network toward eradicating a variety of tumors and ameliorating the self-destructive process. A clinically relevant immune escape mechanism in melanoma is the activation of the Programmed cell Death-1 (PD-1) receptor on infiltrating …

prednisone
nivolumab
metastatic melanoma
immunosuppressant
vitiligo
  • 43 views
  • 23 Jan, 2021
  • 1 location