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Found 557 clinical trials
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A Phase I Clinical Study for Evaluating the Safety and Efficacy of MASCT-I in Patients With Advanced Solid Tumors

The purpose of this study is to evaluate Safety and tolerability of MASCT-I in patients with advanced solid tumors, either alone or in combination with chemical drugs or in combination with PD1 antibody.

metastasis
liver metastasis
chemotherapy drug
serum bilirubin
gemcitabine
  • 81 views
  • 25 Jan, 2021
  • 9 locations
None
Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough

This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with interstitial lung disease (ILD)-related cough.

interstitial lung disease
pirfenidone
nintedanib
tubal ligation
azathioprine
  • 0 views
  • 21 Nov, 2021
  • 1 location
None
Olaparib and Entinostat in Patients With Recurrent Platinum-Refractory Resistant Ovarian Primary Peritoneal Fallopian Tube Cancers

This phase I/II trial studies the side effects and best dose of olaparib and entinostat and to see how well they work in treating patients with ovarian, primary peritoneal, or fallopian tube cancers that have come back or do not respond to platinum-based chemotherapy. Olaparib and entinostat may stop the …

clear cell adenocarcinoma
recurrent disease
ovarian cancer
BRCA1
tumor cells
  • 0 views
  • 24 Jul, 2021
  • 2 locations
None
Nivolumab With Chemotherapy in Pleural Mesothelioma After Surgery

Patients with malignant pleural mesothelioma stage I-III who have undergone cytoreductive surgery with curative intend consisting of extended pleurectomy / decortication (eP/D) with or without hyperthermic intrathoracic chemoperfusion (HITOC) who will receive a maximum treatment duration of 16 cycles (4 cycles of chemotherapy in both arms + 12 cycles maintenance …

pemetrexed
carboplatin
experimental drug
nivolumab
pleurectomy
  • 1 views
  • 25 Feb, 2021
  • 16 locations
None
Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

This phase I/II trial studies the best dose and side effects of peposertib and to see how well it works with avelumab and hypofractionated radiation therapy in treating patients with solid tumors and hepatobiliary malignancies that have spread to other places in the body (advanced/metastatic). Peposertib may stop the growth …

metastasis
measurable disease
international normalized ratio
antibody therapy
anti-cancer agents
  • 129 views
  • 19 Nov, 2021
  • 5 locations
None
Topotecan Plus M6620 (VX-970) vs. Topotecan Alone in People With Relapsed Small-Cell Lung Cancer

Background Small cell cancers are aggressive and grow fast. They can appear in the lungs and in other parts of the body. These tumors often don t respond well to treatment if they come back after chemotherapy. Treatment with two drugs combined may be able to help. Objective To compare …

topotecan
  • 1 views
  • 18 Nov, 2019
  • 1 location
None
Title: Therapeutic Targets in African-American Youth With Type 2 Diabetes

Background The pill metformin treats diabetes. But it does not work for all youth, especially African-Americans. The injectable Liraglutide treats type 2 diabetes in adults. Researchers want to understand how these drugs work and if they decrease excess sugar made by the liver in youth with type 2 diabetes. Objective …

hemoglobin a1c
metformin
sugars
liraglutide
hypoglycemic agents
  • 9 views
  • 31 Oct, 2021
  • 2 locations
None
PROSTVAC in Combination With Nivolumab in Men With Prostate Cancer

Background The immune system is the cells and organs in the body that recognize and fight infection and cancer. The PROSTVAC vaccine might teach the immune system to find and kill certain prostate cancer cells. Nivolumab is a drug that allows the immune system to fight tumors. Itmight help PROSTVAC …

androgens
testosterone level
antiandrogen therapy
prostatectomy
orchiectomy
  • 38 views
  • 21 Nov, 2021
  • 1 location
None
Clonidine to Prevent Delirium After Electroconvulsive Therapy.

Electroconvulsive therapy (ECT) is a highly effective treatment for some psychiatric disorders like major depressive or bipolar disorder, but may lead to agitation and delirium after the procedure in up to 65% of patients. This can have negative side effects and be dangerous for patient and attending staff. Clonidine, a …

electroconvulsive therapy
  • 0 views
  • 03 Jun, 2021
  • 1 location
None
A Study of DSP-0509 in Patients With Advanced Solid Tumors to Determine the Safety and the Pharmacokinetic Profile

This is a multi-center, Phase 1 / 2 clinical study for patients with advanced solid tumors. The study consists of 2 treatment arms - a monotherapy arm and a combination arm. The monotherapy arm has 1 part: Dose Escalation (Part A) The combination arm has Dose Escalation (Part B) only.

measurable disease
gilbert's syndrome
neutrophil count
solid tumor
advanced malignant solid tumor
  • 9 views
  • 01 Dec, 2021
  • 5 locations