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Found 543 clinical trials
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PROSTVAC in Combination With Nivolumab in Men With Prostate Cancer

Background The immune system is the cells and organs in the body that recognize and fight infection and cancer. The PROSTVAC vaccine might teach the immune system to find and kill certain prostate cancer cells. Nivolumab is a drug that allows the immune system to fight tumors. Itmight help PROSTVAC …

antiandrogen therapy
orchiectomy
ct scan
progressive disease
bicalutamide
  • 38 views
  • 12 Sep, 2021
  • 1 location
None
Title: Therapeutic Targets in African-American Youth With Type 2 Diabetes

Background The pill metformin treats diabetes. But it does not work for all youth, especially African-Americans. The injectable Liraglutide treats type 2 diabetes in adults. Researchers want to understand how these drugs work and if they decrease excess sugar made by the liver in youth with type 2 diabetes. Objective …

hemoglobin a1c
sugars
liraglutide
continuous glucose monitoring
metformin
  • 9 views
  • 02 Sep, 2021
  • 2 locations
None
Venetoclax and Quizartinib in Treating Patients With FLT3-mutated Recurrent or Refractory Acute Myeloid Leukemia

This phase Ib/II trial studies the side effects and best dose of venetoclax in combination with quizartinib and how well they work in treating patients with acute myeloid leukemia that has come back or does not respond to treatment, and who are FLT3-mutation positive. Venetoclax and quizartinib may stop the …

  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Adjuvant Sequential & Concurrent CarboTaxol + Radiotherapy for High Risk Endometrial Cancer

The purpose of this trial is to evaluate the safety of sequential and concurrent carboplatin and paclitaxel with adjuvant external beam radiotherapy for locally advanced endometrial cancer. The primary objective is to assess the acute toxicities namely grade 3-4 non hematologic and grade 4 hematologic toxicities associated with the above …

clear cell adenocarcinoma
serous adenocarcinoma
cancer
metastasis
carcinoma
  • 9 views
  • 15 Sep, 2021
  • 1 location
None
Nivolumab With Chemotherapy in Pleural Mesothelioma After Surgery

Patients with malignant pleural mesothelioma stage I-III who have undergone cytoreductive surgery with curative intend consisting of extended pleurectomy / decortication (eP/D) with or without hyperthermic intrathoracic chemoperfusion (HITOC) who will receive a maximum treatment duration of 16 cycles (4 cycles of chemotherapy in both arms + 12 cycles maintenance …

pemetrexed
carboplatin
experimental drug
pleurectomy
nivolumab
  • 1 views
  • 25 Feb, 2021
  • 16 locations
None
Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

This phase I/II trial studies the best dose and side effects of peposertib and to see how well it works with avelumab and hypofractionated radiation therapy in treating patients with solid tumors and hepatobiliary malignancies that have spread to other places in the body (advanced/metastatic). Peposertib may stop the growth …

cancer
metastasis
glomerular filtration rate
m3814
anti-cancer agents
  • 129 views
  • 27 Jun, 2021
  • 5 locations
None
Olaparib and Entinostat in Patients With Recurrent Platinum-Refractory Resistant Ovarian Primary Peritoneal Fallopian Tube Cancers

This phase I/II trial studies the side effects and best dose of olaparib and entinostat and to see how well they work in treating patients with ovarian, primary peritoneal, or fallopian tube cancers that have come back or do not respond to platinum-based chemotherapy. Olaparib and entinostat may stop the …

BRCA1
liver metastasis
serum pregnancy test
olaparib
cancer chemotherapy
  • 0 views
  • 24 Jul, 2021
  • 2 locations
None
Topotecan Plus M6620 (VX-970) vs. Topotecan Alone in People With Relapsed Small-Cell Lung Cancer

Background Small cell cancers are aggressive and grow fast. They can appear in the lungs and in other parts of the body. These tumors often don t respond well to treatment if they come back after chemotherapy. Treatment with two drugs combined may be able to help. Objective To compare …

topotecan
  • 1 views
  • 18 Nov, 2019
  • 1 location
None
ABEMA Alone or in COMBO With MK-6482

This research study will assess whether abemaciclib alone or in combination with MK-6482 are safe and effective in slowing down the growth of clear cell renal cell carcinoma (ccRCC). The names of the study drugs in this investigational combination are: Abemaciclib MK-6482

  • 0 views
  • 08 Apr, 2021
  • 2 locations
None
Cilostazol and Nimodipine Combined Therapy After Aneurysmal Subarachnoid Hemorrhage (aSAH)

The investigators seek to demonstrate that the combined use of cilostazol and nimodipine will significantly decrease the rate of delayed cerebral infarction and cerebral vasospasm after cerebrovascular intervention when compared to nimodipine alone.

  • 2 views
  • 27 Jan, 2021
  • 1 location