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Found 557 clinical trials
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OH2 Oncolytic Viral Therapy in Solid Tumors

This phase I/II study evaluates the safety and efficacy of OH2 as single agent or in combination with HX008, an anti-PD-1 antibody, in patients with malignant solid tumors (gastrointestinal cancers, head and neck cancers, soft tissue sarcomas). OH2 is an oncolytic virus developed upon genetic modifications of the herpes simplex …

cancer
immunoglobulin
solid tumour
sarcoma
measurable disease
  • 17 views
  • 31 Jul, 2021
  • 1 location
None
Bortezomib and Temozolomide in Recurrent Glioblastoma With Unmethylated MGMT Promoter (BORTEM-17)

This phase IB/II trial is designed to investigate the safety and survival benefits for patients with recurrent glioblastoma with unmethylated MGMT promoter treated with Bortezomib and Temozolomide in a specific schedule.

blood transfusion
karnofsky performance status
platelet count
corticosteroids
recurrent tumor
  • 48 views
  • 04 Sep, 2021
  • 2 locations
None
Treatment With Nivolumab and Ipilimumab or Nivolumab Alone According to the Percentage of Tumoral CD8 Cells in Advanced Metastatic Cancer

This is an open-label, exploratory study to evaluate nivolumab with or without ipilimumab based on percentage of tumoral CD8 cells at the time of treatment in participants with varying advanced solid tumors. Participants who have a tumor with 15% CD8 cells (classified as CD8 high) will receive nivolumab monotherapy, and …

  • 2 views
  • 06 Oct, 2021
  • 5 locations
None
Disulfiram and Cisplatin in Refractory TGCTs.

Non-randomized, open-label, single center trial to assess efficacy (as measured by overall response rate (ORR) by RECIST 1.1 of disulfiram and cisplatin in patients with multiple relapsed/refractory germ cell tumors (GCTs).

cancer
cancer chemotherapy
high-dose chemotherapy
high dose chemotherapy
germ cell cancer
  • 15 views
  • 24 Jan, 2021
  • 1 location
None
Gemcitabine Nab-Paclitaxel and Bosentan for the Treatment of Unresectable Pancreatic Cancer

This phase I trial studies the side effects and best dose of bosentan and how well it works when given together with gemcitabine and nab-paclitaxel for the treatment of pancreatic cancer that cannot be removed by surgery (unresectable). Bosentan may block the hormone endothelin and prevent the growth and spread …

  • 0 views
  • 24 Nov, 2021
  • 1 location
None
Stereotactic Body Radiotherapy With or Without Darolutamide for OligoRecurrent Prostate Cancer

The current trial will test the combination of darolutamide with SBRT, in oligometastatic recurrent hormone sensitive prostate cancer. We hypothesize that the addition of short-term darolutamide improves metastasis-free survival when added to SBRT without a detrimental impact on the QoL. Considering the large reluctance of both patients and physicians to …

cancer
adenocarcinoma
radical prostatectomy
  • 0 views
  • 22 Jul, 2021
  • 7 locations
None
Durvalumab and Tremelimumab in Treating Participants With Recurrent or Refractory Ovarian Primary Peritoneal or Fallopian Tube Cancer

This phase II trial studies how well durvalumab and tremelimumab work in treating participants with ovarian, primary peritoneal, or fallopian tube cancer that has come back or does not respond to treatment. Immunotherapy with monoclonal antibodies, such as durvalumab and tremelimumab, may help the body's immune system attack the cancer, …

monoclonal antibodies
neutrophil count
plain x-ray
tumor cells
tremelimumab
  • 112 views
  • 16 Oct, 2021
  • 2 locations
None
Iberdomide Combined With Low-dose Cyclophosphamide and Dexamethasone

Evaluation of the effect iberdomide combined with low-dose cyclophosphamide and dexamethasone in patients with relapsed/refractory multiple myeloma.

cancer
progressive disease
refractory multiple myeloma
lenalidomide
measurable disease
  • 0 views
  • 17 Oct, 2021
  • 9 locations
None
CIML NK Cell in Head & Neck Cancer

This research study is evaluating the safety and efficacy of a combination drug and biologic therapy in patients with advanced head and neck cancer. This research study involves the following drugs and biologics: CIML NK donor cells IL-15 superagonist Ipilimumab

cancer
neutrophil count
oropharyngeal
prednisone
neck cancer
  • 0 views
  • 16 Aug, 2021
None
Decitabine Venetoclax and Ponatinib for the Treatment of Philadelphia Chromosome-Positive Acute Myeloid Leukemia or Myeloid Blast Phase or Accelerated Phase Chronic Myelogenous Leukemia

This phase II trial studies how well the combination of decitabine, venetoclax, and ponatinib work for the treatment of Philadelphia chromosome-positive acute myeloid leukemia or myeloid blast phase or accelerated phase chronic myelogenous leukemia. Drugs used in chemotherapy such as decitabine, work in different ways to stop the growth of …

ponatinib
amylase
serum bilirubin level
leukemia
blast crisis
  • 0 views
  • 06 Nov, 2021
  • 1 location