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Found 561 clinical trials
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R-VRD Followed by Lenalidomide Maintenance in Patients With Waldenstrom's Macroglobulinemia

A multicenter prospective phase II study of rituximab combined, lenalidomide, dexamethasone followed by lenalidomide maintenance in patients with newly diagnosed Waldenstrm's macroglobulinemia (Ballondor trial)

dexamethasone
lenalidomide
rituximab
bortezomib
measurable disease
  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Ruxolitinib and Venetoclax in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

This phase I trial studies the side effects and best dose of ruxolitinib when given together with venetoclax in treating patients with acute myeloid leukemia that has come back (relapsed) or has not responded to treatment (refractory). Ruxolitinib may stop the growth of cancer cells by blocking some of the …

refractory acute myeloid leukemia (aml)
leukemia
hydroxyurea
myeloid leukemia
cancer
  • 3 views
  • 18 Sep, 2021
  • 4 locations
None
A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

This study will test the safety of the study drug, repotrectinib, in combination with chemotherapy (irinotecan and temozolomide) in children and young adults who have advanced or metastatic solid tumors. We researchers will try to find the highest dose of the study drug that causes few or mild side effects …

  • 0 views
  • 01 Dec, 2021
  • 1 location
None
Recombinant Interleukin-15 in Combination With Checkpoint Inhibitors Nivolumab and Ipilimumab in People With Refractory Cancers

Background The drug IL-15 activates the immune system. The drugs nivolumab and ipilimumab unblock immune cells. The drugs together may allow immune cells to recognize and attack cancer cells, causing tumors to shrink. Objective To test the effects and maximum dose of IL-15, nivolumab, and ipilimumab. Eligibility People ages 18 …

  • 0 views
  • 06 Nov, 2021
  • 1 location
None
Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer

This phase I/II trial studies the side effect and best dose of neratinib and to see how well it works with paclitaxel and with or without pertuzumab and trastuzumab before combination chemotherapy in treating patients with breast cancer that has spread to other places in the body (metastatic). Neratinib may …

estrogen receptor
tumor cells
immunohistochemistry
peau d'orange
carcinoma
  • 12 views
  • 28 Mar, 2021
  • 2 locations
None
Study to Nivolumab Following Preoperative Chemoradiotherapy

This is a phase Ib/II, open-label, single-arm, multicenter study to investigate the safety, efficacy, and proof of concept (POC) of monotherapy with nivolumab, an anti-PD-1 antibody drug, as a sequential therapy following chemoradiotherapy (CRT) with capecitabine and subsequent surgical therapy in patients with locally advanced resectable rectal cancer.

capecitabine
chemoradiotherapy
abdominoperineal resection
metastasis
adenocarcinoma
  • 16 views
  • 23 Sep, 2021
  • 3 locations
None
Bortezomib and Temozolomide in Recurrent Glioblastoma With Unmethylated MGMT Promoter (BORTEM-17)

This phase IB/II trial is designed to investigate the safety and survival benefits for patients with recurrent glioblastoma with unmethylated MGMT promoter treated with Bortezomib and Temozolomide in a specific schedule.

blood transfusion
recurrent tumor
karnofsky performance status
temozolomide
corticosteroids
  • 48 views
  • 04 Sep, 2021
  • 2 locations
None
Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab

In this study, the Phase Ib portion aims to establish safety and tolerability of ARRY-614 with either nivolumab or ipilimumab and to determine a recommended phase II dose of ARRY-614 in combination with either nivolumab or nivolumab+ipilimumab immunotherapy in patients with selected advanced solid tumors. The Phase II portion will …

nivolumab
tubal ligation
solid tumour
serum bilirubin
carcinoma
  • 10 views
  • 29 Sep, 2021
  • 1 location
None
A Trial to Evaluate Safety Tolerability Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors

This is an open label Phase 1, First in Human trial of TST001, a recombinant humanized anti-Claudin 18.2 (CLDN18.2) IgG1 monoclonal antibody. It is being tested against advanced and/or metastatic solid tumors including but not limited to gastric cancer/gastroesophageal junction adenocarcinoma, pancreas cancer, gallbladder carcinoma, bile duct carcinoma, lung cancer …

  • 0 views
  • 13 May, 2021
  • 3 locations
None
Exercise Therapy in Radiation Therapy

The purpose of this study is to evaluate exercise therapy as a method for potentially improving radiation therapy treatment toxicities for metastatic cancer patients receiving radiation therapy.

cancer
metastasis
  • 1 views
  • 14 Mar, 2021
  • 1 location