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Found 535 clinical trials
Atezolizumab and Bevacizumab Before Surgery for the Treatment of Resectable Liver Cancer

This phase II trial studies the effect of atezolizumab and bevacizumab before surgery in treating patients with liver cancer that can be removed by surgery (resectable). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor …

  • 0 views
  • 05 Mar, 2022
  • 2 locations
Venetoclax + Decitabine vs. "7+3" Induction Chemotherapy in Young AML

This research is being done to assess the therapeutic efficacy and safety of a promising (venetoclax and decitabine) versus conventional "7+3"chemotherapy in induction young patients with acute myeloid leukemia. This study involves the following: Venetoclax and decitabine (investigational combination) Cytarabine and idarubicin (per standard of care)

  • 0 views
  • 13 Mar, 2022
  • 1 location
Myopia Control Using Bright Light Therapy and Myopic Defocus

The purpose of the study is to investigate the effect of bright light therapy, myopic defocus, and the combination in myopia control in schoolchildren.

anisometropia
Accepts healthy volunteers
astigmatism
  • 0 views
  • 21 Mar, 2022
  • 1 location
Adjuvant Chemotherapy and Anti-PD-1 Antibody in Patients With Stage IIIC2-IVB Cervical Cancer

This phase II study is to Evaluate the Safety and Efficacy of Neoadjuvant Chemotherapy Combined With CCRT Followed by Adjuvant Chemotherapy and Anti-PD-1 Antibody in Patients With Stage IIIC2-IVB Cervical Cancer. CRTCP

metastatic cervical cancer
immunomodulator
neutrophil count
monoclonal antibodies
  • 0 views
  • 17 Jun, 2021
  • 1 location
A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)

This is a single-arm, non-randomized, open-label Phase 2 therapeutic study that will assess the effects of adding BPM31510 onto a conventional treatment framework of RT and concurrent TMZ chemotherapy for subjects with newly diagnosed glioblastoma.

temozolomide
  • 0 views
  • 12 Sep, 2021
  • 4 locations
Noradrenergic Add-on Therapy With Guanfacine (NorAD)

NorAD is a clinical trial funded by the UK National Institute of Health Research. In this trial the investigators will assess whether a long-acting preparation of guanfacine, a drug used to treat Attention Deficit Hyperactivity Disorder in children, can improve thinking (particularly attention) in Alzheimer's Disease when it is added …

donepezil
alzheimer's disease
galantamine
rivastigmine
cognitive assessment
  • 9 views
  • 10 Feb, 2022
  • 1 location
CVM-1118 in Combination With Nivolumab for Unresectable Advanced Hepatocellular Carcinoma

CVM-1118 is a new small molecule chemical entity being developed as a potential anti-cancer therapeutic by TaiRx, Inc. CVM-1118 is a potent anti-cancer agent in numerous human cancer cell lines. The safety of administrating CVM-1118 on human has been evaluated from the phase 1 study. The objective of the phase …

cancer
measurable disease
serum bilirubin
  • 0 views
  • 11 May, 2022
  • 3 locations
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer

This study is an open-label, Phase 1, multicenter study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) profiles of a novel fragment crystallizable (Fc)-engineered immunoglobulin G1 anti-cytotoxic T-lymphocyte antigen 4 (anti-CTLA-4) human monoclonal antibody (botensilimab) monotherapy and in combination with a human monoclonal immunoglobulin G4 antibody (balstilimab), and …

aptt
monoclonal antibodies
bladder cancer, squamous cell carcinoma
renal function
platelet count
  • 15 views
  • 16 May, 2022
  • 14 locations
Effects of Tofacitinib vs Methotrexate on Rheumatoid Arthritis Interstitial Lung Disease (PULMORA)

Pulmonary abnormalities are present in up to 60% of patients with early rheumatoid arthritis (RA), and up to 10% of the patients will develop clinical interstitial lung disease (ILD). Recent data indicate that inhibition of Janus kinase is beneficial for this extra-articular manifestation. Our goal is to determine whether tofacitinib …

interstitial lung disease
methotrexate
prednisone
antirheumatics
DMARD
  • 1 views
  • 10 May, 2022
  • 1 location
Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation

This phase II trial studies how well enasidenib and azacitidine work in treating patients with IDH2 gene mutation and acute myeloid leukemia that has come back (recurrent) or does not respond to treatment (refractory). Enasidenib and azacitidine may stop the growth of cancer cells by blocking some of the enzymes …

cancer
cytarabine
refractory acute myeloid leukemia (aml)
enasidenib
myelomonocytic leukemia
  • 13 views
  • 28 May, 2022
  • 1 location