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Found 34 clinical trials
Microbiome Test for the Detection of Colorectal Polyps

The main goal of this trial is to validate a new method for colorectal polyp screening based on stool microbiome signatures. 600 Individuals who are scheduled / planned to undergo a colonoscopy

colorectal polyps
  • 06 Oct, 2021
  • 2 locations
Hybrid Versus Non-Hybrid Endoscopic Submucosal Dissection for Colorectal Polyps (SHORT-ESD) (SHORT-ESD)

This proposed trial will randomize 60 patients with a ≥20 mm large colorectal polyp to either undergo hybrid or non-hybrid ESD. For the primary comparison (hybrid vs non-hybrid ESD), the primary

  • 07 Oct, 2022
  • 3 locations
Performance Evaluation of CAD-EYE and SCALE-EYE for Detection, Classification, and Measurement of Colorectal Polyps: a Prospective Study

The investigators hypothesize that the clinical implementation of an AI system is an optimal tool to monitor, audit and improve the detection and classification of polyps during colonoscopy. The purpose of this prospective clinical cohort study is to evaluate the performance of the SCALE-EYE virtual scale for measuring polyp size …

  • 04 Oct, 2022
  • 1 location
Polyp Size Measurement During Real-time Colonoscopy Using the Virtual Scale Function SCALE EYE: Variability and Systematic Differences (SCALE EYE)

Size of colorectal polyps is important to decide on appropriate surveillance intervals and treatment modality, as well as carrying out optical diagnosis strategies. However, polyp size

  • 20 Oct, 2022
  • 1 location
Artificial Intelligence for Real-time Detection and Monitoring of Colorectal Polyps

The investigators hypothesize that the clinical implementation of an AI system is an optimal tool to monitor, audit and improve the detection and classification of polyps during colonoscopy. The objectives of this study are to generate preliminary data to evaluate the effectiveness of AI-assisted colonoscopy on: a) the rate of …

  • 13 Mar, 2022
  • 1 location
A Phase 1b Study to Evaluate the Efficacy and Safety of JNJ-64251330, a Janus Kinase (JAK) Inhibitor, in Participants With Familial Adenomatous Polyposis

The purpose of this study is to determine the effect of JNJ-64251330 in participants with Familial Adenomatous Polyposis (FAP) on colorectal polyp burden (sum of the polyp diameters).

  • 28 Oct, 2022
  • 16 locations
Cold Snare Endoscopic Mucosal Resection Trial

This study compares different approaches to endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (20mm) in a 2 x 2 randomized design. The first randomization will

mucosal resection
colorectal polyps
  • 10 Jun, 2021
  • 1 location
Clinical vAliDation of ARTificial Intelligence in POlyp Detection

This study is an open label, unblinded, non-randomized interventional study, comparing the investigational artificial intelligence tool with the current "gold standard": Data acquisition will be obtained during one scheduled colonoscopic procedure by a trained endoscopist. During insertion, no action will be taken, colonoscopy is performed following the standard of care. …

  • 08 May, 2021
Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome (AAS-Lynch)

The proposed trial will evaluate the effect of aspirin 300 mg/d and 100 mg/d during 4 years vs placebo, in a 4 groups randomised parallel design in Lynch syndrome patients: patients with proven carriers of pathological mutations in mismatch repairs genes and patients with personal and family history characterizing Lynch …

acetylsalicylic acid lysinate
  • 08 Jul, 2022
  • 1 location
Efficacy of EndoClot Spraying After Endoscopic Resection of Large Colorectal Polyps

-pedunculated colorectal polyps (20mm) will reduce the risk of delayed bleeding. We hypothesize that EndoClot application will reduce the risk of delayed bleeding by at least 3/4 (i.e. from 7.5% to 1.5%) based

  • 11 Sep, 2021
  • 4 locations