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Found 53 clinical trials
Temozolomide Cisplatin and Nivolumab in People With Colorectal Cancer

This study will test whether the combination of cisplatin, nivolumab, and temozolomide is an effective treatment for in people with advanced and/or metastatic colorectal cancer that is mismatch repair-proficient (MMR-proficient). The researchers will also look at how safe the study drug combination is in participants.

  • 0 views
  • 22 Mar, 2021
  • 7 locations
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

major surgery
liver metastasis
tumor cells
measurable disease
rifampin
  • 72 views
  • 27 Jul, 2021
  • 979 locations
FOLFOX + Panitumumab According to a "Stop and go" Strategy With a Reintroduction Loop After Progression on Fluoropyrimidine as Maintenance Treatment as the First Line in Patients With Metastatic Colorectal Adenocarcinoma Without a RAS Mutation

Single-arm, multi-centre phase II study The primary objective is to evaluate the time to failure of the strategy.

folfox regimen
adenocarcinoma
metastatic colorectal adenocarcinoma
serum bilirubin level
neutrophil count
  • 19 views
  • 05 Mar, 2021
  • 47 locations
Bevacizumab and Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as irinotecan, fluorouracil, and capecitabine, work in …

bevacizumab
combination chemotherapy
tumor growth
platelet count
liver metastasis
  • 5 views
  • 07 Nov, 2020
  • 1 location
lead-in FOLICOLOR Trial: Following Therapy Response Through Liquid Biopsy in Metastatic Colorectal Cancer Patients

Detection of progressive disease by neuropeptide Y (NPY) methylation in liquid biopsies in patients with RAS and BRAF wild-type, unresectable, metastatic colorectal cancer receiving first-line treatment FOLFOX/FOLFIRI and panitumumab.

  • 0 views
  • 14 Feb, 2021
  • 6 locations
Chemotherapy For Metastatic Grade 3 Poorly Differentiated NEuroendocrine Carcinoma Of GastroEnteroPancreatic And Unknown Primary

there is a need for improving chemotherapy regimen for metastatic G3 NEC of GEP and Unknown origin and this goal may be achieved through more "personalized" chemotherapy regimen.the hypothesis is that mFOLFIRINOX regimen could be a good candidate for challenging the platinum-etoposide regimen in patients with metastatic G3 NEC of …

  • 0 views
  • 27 Apr, 2021
  • 6 locations
To Compare Artificial Intelligence Software Aided Adenoma Detection in Screening Colonoscopies Versus Standard Colonoscopy Without Artificial Intelligence Software Assistance in Participants Between 45 and 75 Years of Age

The aim of this study is to assess the efficacy of Ultivision Artificial Intelligence (AI) Software in detecting adenomas in screening colonoscopy procedures. The safety of Ultivision AI Software will also be assessed. A subset of the subjects will enter a roll-in period for clinical trial safety assessment. The remainder …

screening colonoscopy
adenoma
  • 57 views
  • 28 Mar, 2021
  • 10 locations
Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer

This trial studies how well the drug tucatinib works when given with trastuzumab and when given by itself. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). 'Metastatic' means that the cancer has spread to other parts of the body. In the first part of this study, …

bevacizumab
HER2
adenocarcinoma
oxaliplatin
measurable disease
  • 308 views
  • 04 Aug, 2021
  • 81 locations
ePRO for Adjuvant Therapy of Colorectal Adenocarcinoma

It is a multi-centric randomized controlled trial. The goal of this study is to observe the improvement of QoL using ePRO to manage patients with colorectal cancer who received Oxaliplatin-based adjuvant chemotherapy.The prognosis will also be studied.

colorectal adenocarcinoma
adjuvant chemotherapy
adenocarcinoma
oxaliplatin
adjuvant therapy
  • 0 views
  • 24 Jan, 2021
Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases

This phase II trial studies how well chemotherapy and/or metastasectomy work in treating patients with colorectal adenocarcinoma that has spread to the lungs (metastases). Drugs used in

metastatic colorectal adenocarcinoma
complete resection
platelet count
neutrophil count
tumor cells
  • 4 views
  • 10 May, 2021
  • 7 locations