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Found 85 clinical trials
The Characterization of CD34+ Derived Mast Cell Precursors

This study will investigate mast cell precursors that circulate in the blood. In a group of diseases collectively known as mastocytosis, mast cells accumulate in abnormal amounts in the skin, lymphoid tissues, bone marrow, liver and spleen. Some forms of mastocytosis have a generally good prognosis; for others, the prognosis …

Accepts healthy volunteers
blood test
kidney function tests
  • 28 Oct, 2022
  • 1 location
sCD163 in PBC Patients - Assessment of Treatment Response

Primary biliary cholangitis (PBC) is an autoimmune chronic liver disease, characterised by destruction of the small intrahepatic bile ducts. Ursodeoxycholic acid (UDCA) is the first line treatment for patients with PBC. However, up to 40% of patients respond inadequate to this treatment. sCD163 is a macrophage activation marker shedded into …

biopsy of liver
first line treatment
  • 04 Oct, 2022
  • 1 location
Bezafibrate in Patients With Primary Biliary Cholangitis (PBC)

Up to 40% of patients with PBC have an inadequate response to standard treatment with UDCA, hence bezafibrate, a PPAR-agonist is being introduced as add-on therapy in these patients. sCD163, fibrosis markers and bile acid composition are of special interest in PBC. In this study, the investigators will investigate how …

  • 04 Oct, 2022
  • 2 locations
Breakthrough CMV Lung Transplant -Multicentre

Cytomegalovirus (CMV) infection is the most common opportunistic infection in lung transplantation leading to direct and indirect effects that can result in life threatening complications. The risk of CMV infection is highest when the recipient of the transplant has never been in contact with CMV (negative immunity) and the donor …

  • 04 Oct, 2022
  • 1 location
Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response

This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.

  • 04 Oct, 2022
  • 1 location