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Found 114 clinical trials
Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury

Traumatic injury is a leading cause of morbidity and mortality in young adults, and remains a substantial economic and health care burden. Despite decades of promising preclinical and clinical investigations in trauma, investigators understanding of these entities is still incomplete, and few therapies have shown success. During severe trauma, bone …

  • 12 Sep, 2021
  • 1 location
Study of NMS-03592088 in Patients With Relapsed or Refractory AML or CMML

The purpose of this study is to explore safety, tolerability, including the maximum tolerated dose, and antitumor activity of NMS-03592088 in adult patients with relapsed or refractory Acute Myeloid Leukemia (AML) or Chronic Myelomonocytic Leukemia (CMML).

flt3 internal tandem duplication
refractory acute myeloid leukemia (aml)
chronic myelomonocytic leukemia
  • 03 Feb, 2022
  • 4 locations
A Vaccine (H2NVAC) Before Surgery for the Treatment of HER2-Expressing Ductal Carcinoma In Situ

This phase Ib trial studies the side effects and best dose of a vaccine called H2NVAC before surgery in treating patients with HER2 expressing ductal carcinoma in situ. H2NVAC is a vaccine designed to stimulate specialized white blood cells in hopes of increasing immune response and protecting against breast cancer.

carcinoma in situ
platelet count
  • 16 Feb, 2022
  • 2 locations
Study of TVEC in Patients With Cutaneous Squamous Cell Cancer

This is single arm a Phase 2, single center study of talimogene laherparepvec (TVEC) to treat low risk cutaneous squamous cell carcinomas (cSCC).

squamous cell carcinoma
skin cancer
anticoagulant therapy
  • 21 Apr, 2022
  • 2 locations
Study of [11C]CPPC to Assess the Safety and Tolerability in Patients With ALS

The goal of this study is to evaluate the safety of using the [5-cyano-N-(4-(4-[11C]Methylpiperazin-1-yl)-2-(Piperidin-1-yl)Phenyl)Furan-2-carboxamide] ([11C]CPPC) radiotracer in positron emission tomography (PET) imaging of people with amyotrophic lateral sclerosis (ALS). The investigators are also interested to see whether use of this radiotracer reveals imaging differences between patients with ALS and healthy …

primary lateral sclerosis
pregnancy testing
  • 01 Oct, 2021
  • 1 location
A Study of SKLB1028 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory (R/R) AML With FLT3-Mutated

This is a randomizedmulticenter, open-label Phase III, clinical study to confirm the efficacy and safety of SKLB1028 in patients with relapsed or refractory(R/R) FLT3-Mutated Acute Myeloid LeukemiaAMLcompared to salvage chemotherapy.

granulocyte colony stimulating factor
colony stimulating factor
  • 07 Nov, 2021
  • 1 location
Microtransplantation for Advanced and Relapsed Solid Tumors

In this study, we will apply micro transplantation to the field of solid tumors to study the efficacy and safety of radiotherapy and chemotherapy combined with micro transplantation in the treatment of advanced / relapsed solid tumors.

  • 01 Jul, 2021
211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

This phase I/II trial studies the side effects and best dose of a radioactive agent linked to an antibody (211At-BC8-B10) followed by donor stem cell transplant in treating patients with high-risk acute leukemia or myelodysplastic syndrome that has come back (recurrent) or isn't responding to treatment (refractory). 211At-BC8-B10 is a …

leukemic blasts
mycophenolate mofetil
white blood cell count
stem cell transplantation
  • 16 May, 2022
  • 1 location
Reduced Intensity Haploidentical Transplantation for the Treatment of Primary or Secondary Myelofibrosis

This phase II trial studies the outcomes of using a JAK inhibitor prior to reduced intensity haploidentical (Haplo) transplantation for the treatment of primary or secondary myelofibrosis (MF). Haplo transplant has been shown to be safe and effective in patients with leukemia and lymphoma who don't have an available sibling …

  • 06 Jun, 2022
  • 1 location
RBX7455 Before Surgery for the Treatment of Operable Breast Cancer (RBX7455)

This clinical trial studies the side effects and possible benefits of RBX7455 given before surgery in treating patients with breast cancer that can be removed by surgery (operable). RBX7455 contains live intestinal microbes (active drug), which are obtained from healthy human stool and may restore the normal balance of microorganisms …

estrogen receptor
hormone therapy
epidermal growth factor
breast adenocarcinoma
  • 29 May, 2022
  • 1 location