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Found 114 clinical trials
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS

medication called granulocyte colony stimulating factor (G-CSF), and supplemental immunoglobulin (antibody). These therapies are expensive, nonspecific, have significant side effects and toxicities, and do

white blood cell count
neutropenia
norplant
aspermatogenic sterility
neutrophils
  • 112 views
  • 13 Jun, 2022
  • 1 location
Treatment and Natural History Study of Lymphomatoid Granulomatosis

beyond a maximum response, with six cycles minimum. To reduce harm to bone marrow, patients receive granulocyte colony stimulating factor (G-CSF), self-administered by injection under the skin daily for

prednisone
doxorubicin
rituximab
bone marrow procedure
chemotherapy regimen
  • 16 views
  • 19 Jun, 2022
  • 1 location
Total Marrow and Lymphoid Irradiation and Chemotherapy for High-Risk Acute Leukemia

RATIONALE: Giving chemotherapy and total marrow and lymphoid irradiation before allogeneic hematopoietic cell transplant helps stop the growth of leukemia cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may …

myeloid leukemia
ejection fraction
electrocardiogram
blood stem cell transplant
total body irradiation
  • 6 views
  • 22 Jan, 2021
  • 1 location
Total Marrow and Lymphoid Irradiation and Chemotherapy for Myelodysplastic Syndrome or Acute Leukemia

RATIONALE: Giving chemotherapy and total marrow and lymphoid irradiation before allogeneic hematopoietic cell transplant helps stop the growth of leukemia cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may …

tacrolimus
bone marrow procedure
cyclosporine
methotrexate
blood stem cell transplant
  • 17 views
  • 22 Jan, 2021
  • 1 location
CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Blood Cancer Undergoing Donor Stem Cell Transplant

This phase II trial studies how well multi-peptide CMV-modified vaccinia Ankara (CMV-MVA Triplex) vaccination of stem cell donors works in preventing cytomegalovirus (CMV) viremia in participants with blood cancer undergoing donor stem cell transplant. Giving a vaccine to the donors may boost the recipient's immunity to this virus and reduce …

stem cell transplantation
immunosuppressive agents
beta human chorionic gonadotrophin
cytomegalovirus infection
lymphoid leukemia
  • 50 views
  • 04 Mar, 2022
  • 1 location
Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults

After consolidation therapy adult patients (≥18 yr) with Ph-negative ALL will be treated with continuation chemotherapy or allogeneic hematopoietic stem cell transplantation (alloHSCT) according to both measurable residual disease (MRD) and results of genetic study performed at baseline.

consolidation therapy
cell transplantation
residual tumor
  • 1 views
  • 22 Mar, 2022
  • 14 locations
GM-CSF Inhalation to Prevent ARDS in COVID-19 Pneumonia

To assess the safety and tolerability of inhaled molgramostim nebuliser solution in patients with COVID-19 pneumonia.

  • 2 views
  • 29 May, 2021
  • 10 locations
Microtransplantation Combined With Azacytidine to Improve the Efficacy of EAML

Patients enrolled from each center according to confirmed criteria specified in cooperative scheme are recieved induction and consolidation chemotherapy with microtransplantation . Observe the remission rate and 2-year disease-free survival (DFS) and overall survival(OS) rate.

  • 0 views
  • 13 Mar, 2022
  • 1 location
Efficacy and Safety Study of 4-Day ATG Regimen for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT

The purpose of this study is to determine the efficacy and safety of combined ATG #antithymocyte globulin # regimen (5mg/kg divided from day -5 to day -2) for aGVHD(acute graft-versus-host disease ) prophylaxis in matched sibling donor peripheral blood stem cell transplantation (MSD-PBSCT).

  • 0 views
  • 14 Mar, 2022
  • 1 location
Safety of Blood Stem Cell Mobilization With Plerixafor in Patients With Sickle Cell Disease (PISMO)

The objective of this study is to investigate if up to two injections of plerixafor represent a safe and effective strategy to mobilize adequate numbers of CD34+ hematopoietic stem progenitor cells (HSPC) for autologous hematopoietic cell transplantation (HCT) in sickle cell disease (SCD) patients

alloimmunization
stroke
osteonecrosis
acute chest syndrome
blood transfusion
  • 7 views
  • 15 Mar, 2022
  • 1 location