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Found 736 clinical trials
Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery (ASTER)

Prospective multi-center phase 2b randomized placebo-controlled double-blinded interventional platform trial of two different pharmacologic therapies (intravenous Vitamin C or intravenous Acetaminophen) for patients with sepsis-induced hypotension or respiratory failure.

resuscitation
dextrose 5%
assisted ventilation
sepsis
vasopressor
  • 0 views
  • 27 Apr, 2022
  • 8 locations
Rapid Blood Culture Identification Panel in Pediatric Patients in Guatemala

The purpose of this study is to assess the clinical impact of a rapid multiplex PCR blood culture identification panel on time to optimal antimicrobial therapy when compared to conventional microbiological culture methods in children hospitalized in a low resource setting in Guatemala City.

blood culture
antimicrobial agent
antimicrobials
antibiotics
  • 0 views
  • 03 May, 2022
  • 1 location
Insufficient Oxygenation in Septic Patients (INOX-SEPSIS)

This study will describe the change of mitochondrial oxygen tension (mitoPO2) compared to traditional parameters of oxygenation and oxygen balance in the first 24 hours of septic patients admitted to the intensive care unit of an academic hospital. The mitoPO2 will be measured on prespecified measurement moments in the ICU. …

tension
sepsis
pao2
  • 0 views
  • 30 May, 2022
  • 1 location
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches

In light of the rapidly emerging pandemic of SARS-CoV-2 infections, the global population and health care systems are facing unprecedented challenges through the combination of transmission and the potential for severe disease. Acute respiratory distress syndrome (ARDS) has been found with unusual clinical features dominated by substantial alveolar fluid load. …

acute respiratory distress syndrome
respiratory infection
critical illness
respiratory distress
pneumonia
  • 0 views
  • 24 Jan, 2021
Surgical Outcomes of the Accelerometer-based Navigation System for Total Knee Arthroplasty

Osteoarthritis (OA) is a very common condition in the elderly population. Treatment for end-stage OA is total knee Replacement (TKR)

  • 25 views
  • 05 Apr, 2022
  • 1 location
Macro- and Microcirculation Crosstalk in Brain-damaged Patients Under Anesthesia or in Intensive Care (MICRONOR)

In patients with severe brain injury, maintenance and control of blood pressure is at the very first point in the management strategy, whether in anesthesia or in intensive care. In order to restore cerebral perfusion pressure (CPP) to appropriate levels (60-70 mmHg) while ensuring optimal perfusion of other vital organs, …

  • 0 views
  • 03 May, 2022
The Effect of Tranexamic Acid in Total Blood Loss During Proximal Femoral Nailing

Blood loss is an important issue following intertrochanteric femoral fracture and may lead to requiring blood transfusions and transfusion complications. Tranexamic acid is a commonly used drug to decrease blood loss and the number of transfusions. The aim of our study is to determine the effectiveness of tranexamic acid use …

  • 0 views
  • 14 May, 2022
Genomics in Infection and Sepsis to Predict Organ Dysfunction and Outcomes in Sepsis

This is a prospective cohort study using gene expression to study patients with infection and sepsis from pneumonia.

cough
community acquired pneumonia
x-rays
chest x-ray
pneumonia
  • 0 views
  • 21 Feb, 2022
Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure

The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting. Nonetheless, most of the clinical trials aimed at exploring the effect of EBPT on patients' long-term outcomes have failed to demonstrate consistent results regarding 28 dayor hospital- …

organ failure
kidney function tests
hemofiltration
critical illness
cytokines
  • 9 views
  • 24 Mar, 2022
  • 15 locations
Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically Ill Patients

The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting. Nonetheless, most of the clinical trials aimed at exploring the effect of EBPT on patients' long-term outcomes have failed to demonstrate consistent results regarding 28 dayor hospital- …

critical illness
  • 1 views
  • 13 Feb, 2022
  • 12 locations