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Found 730 clinical trials
Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda

BCG vaccination may have non-specific effects (NSE) i.e., additional benefits on childhood morbidity and mortality that are separate the vaccine's effect on the incidence of disseminated tuberculosis. Though the available literature is mostly from observational study designs, and is fraught with controversy, BCG vaccination at birth, in a high risk …

bcg vaccine
Accepts healthy volunteers
  • 23 Feb, 2022
  • 1 location

The PRE-OP ENERGY Trial proposes to test the overarching hypothesis that a pre-surgery high energy diet will protect patients against organ damage during cardiac surgery with cardiopulmonary bypass.

bypass graft
heart surgery
cardiopulmonary bypass
  • 12 Feb, 2022
  • 1 location
Antibiotic Prophylaxis in Patients Undergoing GVO (ABX-GV)

We design a randomized trial to clarify the necessity of antibiotic prophylaxis for the patients chronic liver disease with gastric varices treated by elective GVO.

liver disease
antibiotic therapy
gastric varices
  • 16 Feb, 2022
Novel Arm Restraint For Critically Ill Patients To Reduce Immobility Sedation Agitation and Cognitive Impairment

This study evaluates a novel arm restraint compared with traditional soft wrist restraints in older critically ill patients. The primary outcome is upper extremity mobility measured by actigraphy, and secondary outcomes include sedation, agitation, satisfaction, and acceptability.

critical illness
cognitive impairment
  • 17 Feb, 2021
  • 3 locations
Human Milk Fortification in Extremely Preterm Infants (N-forte)

This is a randomised controlled multi-centre trial comparing the effect of diet supplementation of a human breast milk-based nutrient fortifier (H2MF) with standard bovine protein-based nutrient fortifier in 222 extremely preterm infants (born before gestational week 28+0) exclusively fed with human breast milk (own mothers milk and/or donor milk). The …

human breast milk
enteral feeding
enteral nutrition
antibiotic therapy
  • 04 Mar, 2022
  • 3 locations
Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients

Septic acute kidney injury is a condition associated with highly related to inflammatory molecules. Prebiotics and probiotics have shown to improve inflammatory cascade in animal model; In this study, the investigators propose the use of probiotics to improve the clinical evolution of septic acute kidney injury patients.

  • 04 Sep, 2021
  • 1 location
The Analysis of Immuno-Nutrition Index in Advanced Gastric Cancer Receiving Preoperative Treatments

Based on multiple studies, the immune (systemic inflammation) and nutrition index were correlated with short- and long-term prognosis for gastric cancer. With the increasing application of preoperative treatments (chemotherapy and chemoradiotherapy), the issues concerning how are the immuno-nutrition index be altered under the effects of perioperative treatments and what are …

  • 22 Jan, 2021
  • 1 location
Study of Biomarkers in Patients of Sepsis Complicated With Acute Respiratory Distress Syndrome (ARDS)

Title: Study of Biomarkers in Blood and Alveolar Lavage Fluid Samples of Sepsis Patients Complicated With Acute Respiratory Distress Syndrome (ARDS) Research center: Single-center study. Design of the research: A prospective and cohort study. Object of the research: Patientsage18 yearsthose who meet the diagnostic criteria of sepsis complicated with ARDS …

mechanical ventilation
acute respiratory distress
assisted breathing
assisted ventilation
  • 25 Jan, 2021
  • 1 location
Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest (STEROHCA)

Comatose patients resuscitated from Out-of-Hospital Cardiac Arrest (OHCA) often develop a complicated systemic inflammatory response and have a poor prognosis with neurological damage being the most common cause of death. This study will investigate the anti-inflammatory and neuroprotective effect of early treatment with the glucocorticoid methylprednisolone measured by interleukin-6 and …

inflammatory response
  • 10 Mar, 2022
  • 2 locations
Effect of BPA on Anchor Antibiotic Continuity in the ED: Randomized Controlled Trial

The objective is to compare the timeliness of anchor antibiotic administration in the emergency department (ED) after initial dosing with and without a Best Practice Alert in Epic (BPA) implemented to remind physicians to re-order the antibiotic. We hypothesize that post-BPA implementation, physicians will have a higher rate of ordering …

  • 27 Jan, 2021
  • 1 location