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Found 663 clinical trials
Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris )

Study: Open label, non-randomized, observational, descriptive and prospective pharmacokinetic. Patients: sepsis patients undergoing continuous renal replacement therapy (CRRT) and admitted at the Intensive care unit of Bellvitge University Hospitals. No power calculations needed. Antibiotic treatment: piperacillin, ceftazidime, cefepime, ceftolozane and daptomycin as their standard of care and doses will be …

piperacillin
antibiotics
hemodiafiltration
renal replacement therapy
  • 0 views
  • 11 Sep, 2021
  • 1 location
Administration of Antibiotic Prophylaxis for Transperineal Prostate Biopsy in Cipto Mangunkusumo Hospital

This randomized controlled trial aims to compare the rate of perioperative infection complications in transperineal prostate biopsy between the group that receives prophylactic antibiotic and the group that receives placebo. The types of infection studied included bacteriuria, urinary tract infection (UTI), UTI with fever (febrile UTI), and sepsis. This study …

antibiotic prophylaxis
trimethoprim-sulfamethoxazole
sepsis
bacteriuria
antibiotics
  • 0 views
  • 12 Aug, 2021
  • 1 location
Comparative Effectiveness of Readmission Reduction Interventions for Individuals With Sepsis or Pneumonia (ACCOMPLISH)

An adaptive platform trial to compare effectiveness of different care models to prevent readmissions for patients hospitalized with sepsis or lower respiratory tract infection. The primary outcome is number of days spent at home within 90 days after hospital discharge.

respiratory tract infection
pneumonia
shortness of breath
  • 0 views
  • 04 Oct, 2022
  • 1 location
Plasma Levels of Danger-Associated Molecular Patterns in Young Children After Cardiac Surgery Under Cardiopulmonary Bypass

The investigators have previously reported that cardiac surgery with CPB ( cardiopulmonary bypass) in young infants induced a drastic reduction in mHLA-DR ( Human Leucocyte Antigen) expression, which represents one of innate immune mediator. Danger-Associated Molecular Patterns (DAMPs) can elicit immune response and may subsequentely induce an immune-suppressed state. The …

cardiopulmonary bypass
  • 0 views
  • 22 Sep, 2021
  • 1 location
Bacterial Translocation Markers as Predictors of Infectious and Inflammatory Complications in Acute Bowel Obstruction

Despite modern approaches to the diagnosis and treatment of acute bowel obstruction (ABO), postoperative mortality ranges from 5 to 32%, and complications occur up 23% of cases. One of the formidable infectious and inflammatory complications of ABO is sepsis. The main component of the development of sepsis in ABO is …

sepsis
cancer
  • 0 views
  • 22 Mar, 2022
  • 1 location
Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy

This study will evaluate the use of siltuximab to decrease the severity of cytokine release syndrome (CRS) and immune effector cell-associated neurological syndrome (ICANS) in patients who will receive chimeric antigen receptor (CAR) T-cell therapy for the treatment of hematological malignancies.

platelet count
diffuse large b-cell lymphoma
neutrophil count
multiple myeloma
follicular lymphoma
  • 0 views
  • 07 Dec, 2021
  • 1 location
Multiparametric Cardiac MRI in Patients Under CAR T-cell Therapy

Recently chimeric antigen receptor (CAR) T-cell therapy, a new class of chemo therapy, has gained regulatory approval for the treatment of diseases such as B-cell lymphoma. Known side effects include cytokine release syndrome, which has been described to lead to myocarditis, but larger studies exploring this relationship are currently lacking. …

MRI
lymphoma
cardiac mri
chemotherapy regimen
b-cell lymphoma
  • 0 views
  • 06 Jul, 2022
  • 1 location
Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria

Secondary infections remain a major cause of mortality in critically ill patients, mainly because of high prevalence of multidrug-resistant microorganisms. Therefore strategies aimed to reduce the incidence of ventilator-associated pneumoniae (VAP) and bloodstream infections are of utmost important. There is robust data on selective digestive decontamination (SDD) efficacy in reduction …

pneumonia
antibiotics
vancomycin
assisted ventilation
oropharyngeal
  • 0 views
  • 19 Jun, 2021
  • 1 location
Dyspnea in Stable Patients With Coronary Artery Disease.

Single-centre prospective study to characterize causes of dyspnea in stable patients with coronary artery disease and evaluate the possibility to determine the cause of dyspnea before in-depth examination.

stenosis
arterial disease
exercise stress test
infarct
coronary artery stenosis
  • 0 views
  • 04 Sep, 2021
  • 1 location
Scrub Typhus Infection Induced Cardiovascular Disease

Scrub typhus infection has been considered as seasonal and endemic infectious disorder with benign feature. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia and cause of death could be a fetal complicating cardiovascular disease. Therefore, the association and predictors for scrub typhus induced …

cardiovascular disease
  • 9 views
  • 27 Apr, 2022
  • 2 locations