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Found 650 clinical trials
Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia

In general, the percentage of complete remissions is 85 - 90 % for acute lymphoid leukemia (ALL). In developing countries, percentages are lower secondary to higher sepsis-related mortality. Although the effect of statins on inflammatory response associated with sepsis has been demonstrated, including an effect on bacterial proliferation in patients …

inflammatory response
cancer
  • 0 views
  • 24 Mar, 2022
  • 1 location
Percutaneous Left Stellate Ganglion Block In Out-of-hospital Cardiac Arrest Due to Refractory VEntricular Arrhythmias (LIVE Study) (LIVE)

A prospective uncontrolled study to verify the feasibility and practicability of percutaneous stellate ganglion block (PSGB) in patient suffering from a refractory out-of-hospital cardiac arrest (OHCA) due to a shockable rhythm and the eventual occurrence of complication related to it. The study will also assess whether the rate of return …

stellate ganglion block
  • 1 views
  • 18 Feb, 2022
  • 1 location
Antibiotic Prophylaxis in Patients Undergoing GVO (ABX-GV)

We design a randomized trial to clarify the necessity of antibiotic prophylaxis for the patients chronic liver disease with gastric varices treated by elective GVO.

gastric varices
liver disease
antibiotic therapy
antibiotics
endoscopy
  • 3 views
  • 16 Feb, 2022
Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest (STEROHCA)

Comatose patients resuscitated from Out-of-Hospital Cardiac Arrest (OHCA) often develop a complicated systemic inflammatory response and have a poor prognosis with neurological damage being the most common cause of death. This study will investigate the anti-inflammatory and neuroprotective effect of early treatment with the glucocorticoid methylprednisolone measured by interleukin-6 and …

interleukin-6
inflammatory response
  • 0 views
  • 10 Mar, 2022
  • 2 locations
Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections (BGN)

Antimicrobial resistance is a major global problem, particularly in hospital-acquired infections (HAIs). Gram-negative bacilli (GNB), including Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii, are among the most common pathogens associated with multidrug resistance and HAIs. These bacteria are of special concern because few therapeutic options are available. Traditionally, the duration of …

severe infection
bloodstream infection
antibiotics
antimicrobials
antimicrobial agent
  • 0 views
  • 24 Mar, 2022
  • 4 locations
A Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients

A Phase 2, Multi-Center, Randomized, Placebo-Controlled, Dose-Finding Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients

sepsis
fever
chills
pneumonia
antibiotics
  • 0 views
  • 07 Oct, 2022
  • 14 locations
Febrile Infant Diagnostic Assessment and Outcome Study (FIDO)

Febrile infants under 3 months of age represent a high risk group for serious bacterial infection (SBI) with approximately 10-20% having bacteremia, meningitis or urinary tract infection. The assessment of febrile infants is challenging, and current National Institute for Health and Care Excellence (NICE) guidance advocates a cautious approach with …

fever
bacteremia
meningitis
antibiotics
  • 0 views
  • 07 Oct, 2022
  • 1 location
Prebiotic Inulin to Limit Antimicrobial-Resistant Infections During Critical Illness: A Phase II Clinical Trial

Normal gut bacteria prevent colonization and subsequent infection with MDR organisms (MDROs) through competition for resources and other mechanisms. During critical illness, this function of the microbiome is lost and there are no current treatments to restore it. Preliminary data indicates that the prebiotic fiber inulin is safe and may …

  • 0 views
  • 27 Oct, 2022
  • 1 location
Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT) (GlobalARRT)

Worldwide, the use of Extracorporeal Blood Purification (EBP) in everyday clinical practice is becoming increasingly common, particularly in critical care settings. The efficacy of most of these treatments on removal of inflammatory mediators is the main rationale behind the use of EBP in critically ill patients with multiorgan dysfunction. Nonetheless, …

renal replacement therapy
cytokines
  • 0 views
  • 25 Mar, 2022
  • 1 location
Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure

The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting. Nonetheless, most of the clinical trials aimed at exploring the effect of EBPT on patients' long-term outcomes have failed to demonstrate consistent results regarding 28 dayor hospital- …

kidney function tests
cytokines
critical illness
organ failure
hemofiltration
  • 9 views
  • 24 Mar, 2022
  • 15 locations