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Found 12 clinical trials
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Evaluating a Novel Individualised Treatment Strategy for Carbapenem-Resistant Gram-Negative Bacteria Infections

Carbapenem-resistant (CR) Gram negative bacteria (GNB) - which are resistant to carbapenems (a last-line potent antibiotic with a high therapeutic index) - are also resistant to all other beta-lactam antibiotics. Most CRGNB are also extensively-drug resistant (XDR) (resistant to all classes of antibiotics except polymyxins and/or tigecycline) or pan-drug resistant …

  • 13 views
  • 18 Oct, 2021
  • 1 location
None
Efficacy and Safety of Colistin for Therapy of Infections Caused by ESBL Producing K.Pneumoniae or E.Coli

In patients with documented ESBL-producing E.coli and Klebsiella pneumoniae will be allocated to receive colistin or conventional antibiotic regimen.

antibiotic therapy
antibiotics
  • 2 views
  • 07 Nov, 2020
  • 1 location
None
A Randomized Controlled Trial Comparing Imipenem and Tigecycline Versus Imipenem and Tigecycline With GM-CSF for the Management of Spontaneous Bacterial Peritonitis Presenting With Septic Shock.

. Patients with recent hospitalisation will be given Colistin in addition. Group B will be given: To another group we will give Imipenem and Tigecycline and GMCSF.Patients with recent hospitalisation

  • 17 views
  • 24 Feb, 2021
  • 1 location
None
A Study to Determine the Efficacy Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) Metronidazole (MTZ) Versus Meropenem (MER) Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria.

A Phase 3 comparative study to determine the efficacy, safety and tolerability of Aztreonam-Avibactam (ATM-AVI) Metronidazole (MTZ) versus Meropenem (MER) Colistin (COL) for the treatment of

colistin
ct scan
antibiotic therapy
antibiotics
meropenem
  • 225 views
  • 30 Nov, 2021
  • 190 locations
None
Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients

Introduction- Hospital acquired infections (HAI) are a major cause of morbidity and mortality and increase health care costs. Critically ill patients are particularly susceptible to these infections and have an even higher mortality. One intervention that has gained much interest in the medical literature for reducing infection rates and deaths …

nosocomial infections
critical illness
mechanical ventilation
antibiotic therapy
antibiotics
  • 13 views
  • 28 Jan, 2021
  • 3 locations
None
Intravenous Colistin Versus Intravenous Colistin Plus Nebulized Colistin in VAP Due MDR Acinetobacter Baumannii

Compare the clinical efficiency evaluated by the treatment of the intravenous colistin plus inhaled colistin opposite to the treatment with colistin intravenous plus inhaled saline

cpis
carbapenem
pulmonary infection
colistin
  • 11 views
  • 07 Nov, 2020
  • 1 location
None
Colistin Intravenous Administration in Critically Ill Patients Suffering From Hospital Infections Caused by Multi-antibiotic-resistant Germs.

Colistin is an antibiotic active against several classes of multi-resistant gram-negative bacteria; the drug should be used in high doses in patients on continuous renal replacement therapy

  • 0 views
  • 15 Aug, 2021
  • 1 location
None
Population Pharmacokinetic-pharmacodynamic (PK-PD) Study of 9 Broad-Spectrum Anti-infective Agents in the Cerebro Spinal Fluid (CSF) of Brain Injured Patients With an External Ventricular Drainage (EVD).

indicated in CNS infections (vancomycin, daptomycin, ceftazidime, meropenem, colistin, linezolid, piperacillin-tazobactam and ceftaroline) and to study the Cefepime diffusion in the CSF, known to be highly

  • 0 views
  • 26 Sep, 2021
  • 1 location
None
Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.

Acute on chronic liver failure (ACLF) is a distinct entity where, because of severe acute hepatic injury, a rapid loss of liver function develops in a patient with previous chronic liver disease(4). These patients have severe hepatic dysfunction, and outcome is defined by functional hepatic reserve and extent of extra-hepatic …

vasoconstriction
diuretic
drug induced liver injury
cytokines
renal failure
  • 0 views
  • 17 Oct, 2021
  • 1 location
None
Detection of Colistin-resistant Isolates From Patients of Intensive Care Units and Oncohaematology Wards.

The increasing use of colistin in multidrug resistant strains, as Enterobacteriaceae producing extended-spectrum -lactamases or carbapenemases, is associated with the emergence of colistin

  • 0 views
  • 24 Jan, 2021
  • 4 locations