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Found 1328 clinical trials
Identification of Cardiovascular and Molecular Prognostic Factors for the Mid- and Long-term Outcome of Sepsis (ICROS)

Sepsis is a life-threatening condition which can affect people of any age. An infection triggers a host response resulting in organ failure. The extent of the organ dysfunction varies between patients and during the course of the condition. Thus far, the only causal treatment option consists in treating the infection …

septic shock
organ failure
electrocardiogram
shock
fibrosis
  • 9 views
  • 23 Apr, 2022
  • 1 location
Renal Oxygen Saturation During Off-pump Coronary Artery Bypass Graft Surgery (OPCAB)

The purpose of this study is to evaluate changes in renal oxygen saturation (rrSO2) and its relationship with central venous oxygen saturation (cvSO2), cerebral cortical oxygen saturation (rcSO2), and hemodynamic parameters while displacing the heart for each coronary anastomosis in 19-80 year old adult patients receiving off-pump coronary artery bypass …

general anesthesia
  • 0 views
  • 24 Mar, 2022
  • 1 location
Neuroinflammation in Chronic Systemic Symptoms (CSS)

The purpose of the present research protocol is to investigate and identify translocator protein 18kDa, MRI DTI, and EEG/ERPs, markers of Chronic Systemic Symptoms (CSS).

  • 0 views
  • 19 Sep, 2021
  • 1 location
Associations of Carotid Plaque Characteristics With Brain Perfusion and Cognitive Function in Patients Undergoing CEA

Stroke is one of the leading causes of death and disability-adjusted life-years worldwide. Carotid high-risk atherosclerotic plaques are considered to be one of the major sources of ischemic stroke. The present study aimed to investigate the relationship of carotid plaque characteristics with brain perfusion and cognitive function in patients undergoing …

  • 0 views
  • 18 Jul, 2021
  • 1 location
CD8+ T-cell PET/CT Imaging in COVID-19 Patients (Tangelo)

A subset of patients diagnosed with severe acute respiratory syndrome (SARS)-CoV2 infection present with lymphopenia. The degree of lymphopenia, and in particular reduced cluster of differentiation (CD)8+ T-cell numbers, is correlated with clinical deterioration and intensive care unit (ICU) admission. The underlying reasons for lymphopenia in coronavirus disease (COVID)-19 is …

  • 0 views
  • 18 Jun, 2022
  • 1 location
Reading Outcomes in Children With Vestibular Loss

Vestibular loss can co-occur with hearing loss causing dual sensory deficits. This project examines vestibular loss as a contributing factor to reading difficulties for children with hearing loss, where previously only the effects of hearing loss and subsequent language difficulties have been considered. These results are expected to influence the …

Accepts healthy volunteers
  • 0 views
  • 28 Jun, 2022
  • 1 location
Impact of Elastin Mediated Vascular Stiffness on End Organs

Background People with Williams Syndrome (WS) and supravalvular aortic stenosis (SVAS) have less elasticity in their blood vessels. This is called blood vessel stiffness. Blood vessels may have focal narrowings called stenoses or may just be globally more narrow. Objectives Researchers want to see how blood vessel differences in people …

stenosis
Accepts healthy volunteers
supravalvular aortic stenosis
  • 66 views
  • 14 Oct, 2022
  • 1 location
Risk and Protective Factors in Multimodal Pain Therapy in Patients With Chronic Lumbal Pain

Results will show important information about potential protective factors which might be relevant for the recovery of patients suffering from low back pain (theoretical basis). On a clinically applied basis we plan the validation of a short screening in concerns of psychosocial risk and protective factors in patients with chronic …

  • 0 views
  • 25 May, 2022
  • 1 location
Gray Matter Demyelination in Primary Progressive MS at 7T

Progressive-onset multiple sclerosis (PPMS) occurs in about 15% of all people living with MS. PPMS remains understudied, and most disease-modifying treatments are ineffective for PPMS. To date, it is unknown why some people progress immediately from MS onset. The present study will assess the role of gray matter in PPMS …

Accepts healthy volunteers
disease or disorder
MRI
demyelination
  • 0 views
  • 16 Jun, 2022
  • 1 location
Metrology to Enable Rapid and Accurate Clinical Measurements in Acute Management of Sepsis (SEPTIMET)

Sepsis is a life-threatening condition that arises when a dysregulated response to infection results in multi-organ dysfunction or failure. This can affect any organ, resulting in a diverse clinical presentation. Sepsis affects more than 3.4 million Europeans a year with 700,000 deaths from the condition and an additional one third …

septic shock
shock
inflammatory response
procalcitonin
sepsis
  • 0 views
  • 30 Apr, 2022