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Found 1272 clinical trials
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)

In this study, we will conduct retrospective chart and imaging reviews and prospective longitudinal virtual assessments of individuals with LBSL.

genetic analysis
  • 25 Jan, 2021
  • 1 location
Neuroinflammation in Chronic Systemic Symptoms (CSS)

The purpose of the present research protocol is to investigate and identify translocator protein 18kDa, MRI DTI, and EEG/ERPs, markers of Chronic Systemic Symptoms (CSS).

  • 27 Jan, 2021
  • 1 location
Associations of Carotid Plaque Characteristics With Brain Perfusion and Cognitive Function in Patients Undergoing CEA

Stroke is one of the leading causes of death and disability-adjusted life-years worldwide. Carotid high-risk atherosclerotic plaques are considered to be one of the major sources of ischemic stroke. The present study aimed to investigate the relationship of carotid plaque characteristics with brain perfusion and cognitive function in patients undergoing …

  • 18 Jul, 2021
  • 1 location
Renal Oxygen Saturation During Off-pump Coronary Artery Bypass Graft Surgery

The purpose of this study is to evaluate changes in renal oxygen saturation (rrSO2) and its relationship with central venous oxygen saturation (cvSO2), cerebral cortical oxygen saturation (rcSO2), and hemodynamic parameters while displacing the heart for each coronary anastomosis in 19-80 year old adult patients receiving off-pump coronary artery bypass …

  • 26 Jan, 2021
  • 1 location
Pediatric Type 1 Diabetes and Neurocognitive Complications Cohort Study

The proposed project will assess hypothesized risk factors (age of onset, Diabetic ketoacidosis (DKA) at presentation and glycemic control), as well as potentially modifiable protective factors (child sleep quality, caregiver distress, and use of diabetes devices). In addition, the study will optimize imaging protocols and processing tools to allow for …

  • 03 Feb, 2021
  • 1 location
The Effect of CPAP Treatment on Cognitive Functions Anxiety and Affective Symptoms

Long term, prospective study of continuous positive airway pressure treatment influence on cognitive functions in patients with obstructive sleep apnea syndrome.

apnea-hypopnea index
continuous positive airway pressure
  • 23 Jul, 2021
  • 1 location
Impact of Elastin Mediated Vascular Stiffness on End Organs

Background People with Williams Syndrome (WS) and supravalvular aortic stenosis (SVAS) have less elasticity in their blood vessels. This is called blood vessel stiffness. Blood vessels may have focal narrowings called stenoses or may just be globally more narrow. Objectives Researchers want to see how blood vessel differences in people …

supravalvular aortic stenosis
  • 20 Jul, 2021
  • 1 location
Hepatic Urea Nitrogen Handling in Patients With NASH

The aim of the project is to investigate the metabolic regulation of the hepatic urea nitrogen handling and various cognitive functions measured by psychometric and neurophysiological tests before and after bariatric surgery in patients with non-alcoholic fatty liver disease (NAFLD).

liver disease
bariatric surgery
other liver diseases
fatty liver
  • 24 Jan, 2021
  • 1 location
Brain Functional MRI in Older Women With Breast Cancer (Brain fMRI-BC)

This study will use advanced MRI techniques to characterize the changes that occur to the structure and functionality of the brain in older breast cancer patients receiving adjuvant chemotherapy, and determine the relationship between the brain changes and severity of chemotherapy toxicity. Our results will be an early step towards …

adjuvant chemotherapy
  • 21 Mar, 2021
  • 2 locations
Metabolic Syndrome in Childhood Cancer Survivors

The research is devoted to studying the features of the metabolic syndrome in cancer survivors in childhood is supposed to answer the following questions: How can metabolic syndrome be diagnosed in the Russian population of survivors of acute lymphoblastic leukemia and non-Hodgkin's lymphomas? What are the features of the clinical …

  • 22 Jan, 2021
  • 1 location