Found 734 clinical trials
Safety and Efficacy of AMT-130 in European Adults With Early Manifest Huntington Disease
This is the second study of AMT-130 in patients with early manifest HD and is designed as part of an integrated two-study phase I/II program under a single data safety monitoring board (DSMB) with staggered enrollment based upon continued demonstration of safety of AMT-130 administration.
- 0 views
- 21 Mar, 2022
- 1 location
TEsting METformin Against Cognitive Decline in HD
Multicenter, randomized, double-blind, placebo-controlled, parallel group study to assess the efficacy and safety of metformin treatment at a dose of 1700 mg / day in adults with Huntington's disease. The study consists of a screening period (2 to 4 weeks), followed by a 52-week double-blind treatment period and a follow-up …
- 0 views
- 23 Apr, 2022
- 7 locations
A Biomarker Database to Investigate Blood-Based and Digital Biomarkers in Participants Screened for Alzheimer's Disease (Bio-Hermes)
The purpose of this study (Bio-Hermes) is to develop a blood, digital, and brain amyloid PET scan biomarker database that can be used to determine whether a meaningful relationship exists between digital tests, blood amyloid-beta, p-tau, and neurofilament biomarker levels and amyloid-beta levels identified through brain amyloid PET images. Blood …
- 0 views
- 25 Mar, 2022
- 12 locations
New Approaches to Dementia Heterogeneity.
This study is looking for adults who have mild cognitive impairment, Alzheimer’s, or other forms of dementia. The study is also looking for people with normal cognition, as a comparison. The study is interested in the ways that brain function changes over time with the goal of improving the ability to diagnose …
- 154 views
- 25 May, 2021
- 1 location
PST for Care Partners of Adults With Alzheimer's and Alzheimer'S-related Dementia
Caregivers of individuals with Alzheimer's disease and related dementia rarely get the preparation or training they need to manage their caregiving responsibilities and to successfully balance their own self-care and their caregiving roles. As a result, caregivers often experience caregiver burden, emotional distress, and substance abuse. Therefore, there is a …
- 2 views
- 25 Jan, 2022
- 2 locations
tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study
The proposed study will evaluate a new approach to cognitive rehabilitation of mild traumatic brain injury (mTBI) using a brain stimulation technique called transcranial direct current stimulation (tDCS). Specifically, we will investigate how tDCS combined with cognitive training improves deficits to attention and working memory in Active Duty Service Members …
- 0 views
- 25 Jan, 2022
- 1 location
BEAM: Brain-Eye Amyloid Memory Study (BEAM)
The main objectives for this study are: To investigate novel, non-invasive ocular measurements including optical coherence tomography and eye tracking in a cross-sectional study of participants with various neurodegenerative dementias against standard cognitive assessments and brain imaging measures; and To assess the potential utility of ocular assessments for early detection …
- 32 views
- 25 Jan, 2022
- 5 locations
NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)
A Study to Evaluate NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Associated With Parkinson's Disease or Prodromal or Manifest Lewy Body Dementia
- 637 views
- 16 Jun, 2022
- 25 locations
Healthy Brain Aging Study
This study is looking for people who are 18 or older and have the early stages of various neurological conditions like Alzheimer’s, mild cognitive impairment, Lewy Body disease, or Parkinson’s disease. The study is also looking for cognitively normal people over the age of 70, as a comparison. Participants will …
- 0 views
- 24 Jan, 2022
- 1 location
Measuring Cortisol Levels in Persons With Parkinson's (PD) (CORT-PD)
The objective of this study is to evaluate the cortisol awakening response with persons with Parkinsons Disease (PD), Huntingtons Disease (HD), and controls. These data are desired so experience can be gained with measuring stress levels subjectively and objectively in persons with PD, HD, and controls.
- 160 views
- 09 May, 2022
- 2 locations