Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 734 clinical trials
Safety and Efficacy of AMT-130 in European Adults With Early Manifest Huntington Disease

This is the second study of AMT-130 in patients with early manifest HD and is designed as part of an integrated two-study phase I/II program under a single data safety monitoring board (DSMB) with staggered enrollment based upon continued demonstration of safety of AMT-130 administration.

htt gene
  • 0 views
  • 21 Mar, 2022
  • 1 location
TEsting METformin Against Cognitive Decline in HD

Multicenter, randomized, double-blind, placebo-controlled, parallel group study to assess the efficacy and safety of metformin treatment at a dose of 1700 mg / day in adults with Huntington's disease. The study consists of a screening period (2 to 4 weeks), followed by a 52-week double-blind treatment period and a follow-up …

cognitive decline
  • 0 views
  • 23 Apr, 2022
  • 7 locations
A Biomarker Database to Investigate Blood-Based and Digital Biomarkers in Participants Screened for Alzheimer's Disease (Bio-Hermes)

The purpose of this study (Bio-Hermes) is to develop a blood, digital, and brain amyloid PET scan biomarker database that can be used to determine whether a meaningful relationship exists between digital tests, blood amyloid-beta, p-tau, and neurofilament biomarker levels and amyloid-beta levels identified through brain amyloid PET images. Blood …

Accepts healthy volunteers
mini-mental state examination
amyloid
dementia
alzheimer's disease
  • 0 views
  • 25 Mar, 2022
  • 12 locations
Featured trial
New Approaches to Dementia Heterogeneity.

This study is looking for adults who have mild cognitive impairment, Alzheimer’s, or other forms of dementia. The study is also looking for people with normal cognition, as a comparison. The study is interested in the ways that brain function changes over time with the goal of improving the ability to diagnose …

cancer
heart disease
mild cognitive impairment
stroke
amyotrophic lateral sclerosis
  • 154 views
  • 25 May, 2021
  • 1 location
PST for Care Partners of Adults With Alzheimer's and Alzheimer'S-related Dementia

Caregivers of individuals with Alzheimer's disease and related dementia rarely get the preparation or training they need to manage their caregiving responsibilities and to successfully balance their own self-care and their caregiving roles. As a result, caregivers often experience caregiver burden, emotional distress, and substance abuse. Therefore, there is a …

Accepts healthy volunteers
alzheimer's disease
dementia
  • 2 views
  • 25 Jan, 2022
  • 2 locations
tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study

The proposed study will evaluate a new approach to cognitive rehabilitation of mild traumatic brain injury (mTBI) using a brain stimulation technique called transcranial direct current stimulation (tDCS). Specifically, we will investigate how tDCS combined with cognitive training improves deficits to attention and working memory in Active Duty Service Members …

brain stimulation
cognitive training
cognitive rehabilitation
concussion
traumatic brain injury
  • 0 views
  • 25 Jan, 2022
  • 1 location
BEAM: Brain-Eye Amyloid Memory Study (BEAM)

The main objectives for this study are: To investigate novel, non-invasive ocular measurements including optical coherence tomography and eye tracking in a cross-sectional study of participants with various neurodegenerative dementias against standard cognitive assessments and brain imaging measures; and To assess the potential utility of ocular assessments for early detection …

mental state examination
early diagnosis
cognitive impairment
Accepts healthy volunteers
brain imaging
  • 32 views
  • 25 Jan, 2022
  • 5 locations
NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)

A Study to Evaluate NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Associated With Parkinson's Disease or Prodromal or Manifest Lewy Body Dementia

cognitive impairment
parkinson's disease
dementia
cognitive assessment
mild cognitive impairment
  • 637 views
  • 16 Jun, 2022
  • 25 locations
Featured trial
Healthy Brain Aging Study

This study is looking for people who are 18 or older and have the early stages of various neurological conditions like Alzheimer’s, mild cognitive impairment, Lewy Body disease, or Parkinson’s disease.  The study is also looking for cognitively normal people over the age of 70, as a comparison.  Participants will …

cognitive impairment
mild cognitive impairment
Accepts healthy volunteers
  • 0 views
  • 24 Jan, 2022
  • 1 location
Measuring Cortisol Levels in Persons With Parkinson's (PD) (CORT-PD)

The objective of this study is to evaluate the cortisol awakening response with persons with Parkinsons Disease (PD), Huntingtons Disease (HD), and controls. These data are desired so experience can be gained with measuring stress levels subjectively and objectively in persons with PD, HD, and controls.

Accepts healthy volunteers
nervous system disorder
parkinson's disease
chorea
movement disorder
  • 160 views
  • 09 May, 2022
  • 2 locations