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Found 736 clinical trials
Fitness for Brain Optimization for Late-Life Depression

Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with …

  • 12 Aug, 2021
  • 1 location
TAME-PD - Physical Therapy, Atomoxetine and, Methylphenidate, to Enhance Gait and Balance in Parkinson's Disease (TAME-PD)

Gait and balance problems are a significant source of disability in patients with Parkinson disease. Physical therapy remains one of the main treatments. On the other hand some medications, such as methyphenidate and atomoxetine, have been tried with promising results. The outcomes in gait and balance in Parkinson disease after …

medication regimen
  • 23 Mar, 2022
  • 1 location
Internet-based WOrk-related Cognitive Rehabilitation for Cancer Survivors: a Randomized Controlled Trial (i-WORC)

Many of the occupationally active cancer survivors experience cognitive problems.Both from an individual and a societal perspective, it is important to sustain cancer survivors' employability.The aim of the current study is to develop an internet-based cognitive intervention programme for occupationally active cancer survivors confronted with cognitive problems, and to evaluate …

  • 15 May, 2022
  • 1 location
Ball Blankets on Insomnia in Depression in Outpatient Clinics

The objective of the study is to examine the efficacy of Protac Ball BlanketsTM (PBB) and specifically if the PBB will extend the total sleep time of patients with insomnia due to depression in two psychiatric outpatient clinics at Aarhus University Hospital and Odense University Hospital. Furthermore, it will be …

  • 04 Jun, 2022
  • 2 locations
The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study (SINGER)

A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility …

Accepts healthy volunteers
cognitive decline
  • 24 Jan, 2022
  • 2 locations
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients (CODEX)

, many patients have persistent memory impairment for weeks to months after surgery. Cardiac surgery appears to carry the highest risk of postoperative cognitive dysfunction (POCD). These cognitive

coronary artery bypass graft
cognitive deficits
postoperative cognitive dysfunction
cognitive disorder
  • 28 Feb, 2022
  • 1 location
Implementation and Effectiveness of Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship (ENCOMPASS)

a sepsis hospitalization and include: 1) identification and treatment of new physical, mental, and cognitive deficits; 2) review and adjustment of medications; 3) surveillance of treatable

organ failure
inflammatory response
antibiotic therapy
white blood cell count
  • 30 Apr, 2022
  • 1 location
Swedish Iodine in Pregnancy and Development in Children (SWIDDICH) Study

cognitive development of the fetus or is there no cognitive deficit from mild ID and no extra iodine is needed?". To answer this question, the investigators planned a randomized, placebo-controlled trial of

  • 30 Sep, 2021
  • 5 locations
A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease (Autonomy)

The primary purpose of this study is to evaluate the effect of JNJ-63733657 versus placebo on clinical decline as measured by the Integrated Alzheimer's Disease Rating Scale (iADRS), a composite of cognition and function.

alzheimer's disease
cognitive decline
cognitive assessment
  • 03 Jun, 2022
  • 112 locations
Implementation of an Infusion Management Scheme to Improve Patient Outcome in Tertiary Children's Hospitals

This study is a multi-center before-after trial design. The object is to observe whether the incidence of central line associated blood stream infection(CLABSI) will tend to descend compared with retrospective electronic medical record data after implementation of an infusion management scheme which comes form " Clinical Practice Guideline on Infusion …

  • 27 Apr, 2022
  • 7 locations