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Found 735 clinical trials
add-on Low Dose Memantine in Middle-to-old Aged Bipolar II Disorder Patients

The investigators hypothesized that add-on memantine (MM) 5 mg/day may reduce chronic inflammation, and subsequently improve neuro-progression process and cognitive function in middle-to-old aged bipolar II disorder (BP-II) patients. In current proposal, the investigators will conduct a randomized double-blind placebo-controlled study. The investigators will recruit 100-120 patients with BP-II who …

  • 19 Mar, 2021
  • 1 location
Cannabidiol on Reward- and Stress-related Neurocognitive Processes in Individuals With Opioid Use Disorder

The purpose of this study is to determine the impact of cannabidiol on reward- and stress-related neurocognitive processes among individuals with opioid use disorder on buprenorphine or methadone treatment.

  • 30 Apr, 2022
  • 1 location
Cardiopulmonary Rehabilitation in Long COVID-19 Patients With Persistent Breathlessness and Fatigue

The objective of this project is to assess the effects of a 2-month cardiopulmonary rehabilitation program on cardiorespiratory fitness in long COVID19 patients. Quality of life, functional capacity, functional respiratory capacity, inflammatory profile, coagulation markers, cognitive functions and brain O2 saturation will also be assessed before and after the exercise …

  • 12 Sep, 2021
  • 1 location
Novel Parameters for the Prediction of Ventriculoperitoneal Shunting Efficacy in Patients With iNPH (iNPH)

INPH is a chronic, progressive disease characterised by enlarged ventricles in the absence of elevated intracranial pressure. Patients often present with the Hakim triad comprising gait disturbance, dementia and urinary incontinence. Treatment consists of ventriculoperitoneal (VP) shunting reducing the cerebrospinal fluid (CSF) volume in the central nervous system (CNS); a …

  • 03 Jun, 2022
  • 1 location
Developmental Dyslexia and Remediation Methods (DDMR)

At least, three theoretical frameworks are currently involved in therapeutic research in developmental dyslexia. Each theoretical framework relies on the type of underlying cognitive processes that is viewed as impaired: 1) phonological processing, 2) cross modal integration, 3) visual attention processing. In this controlled and randomized study, three types of …

rehabilitation treatment
developmental dyslexia
  • 26 Feb, 2022
Metacognitive Training With Bipolar Disorder Patients.

The aim of this research project is to evaluate the efficacy of Metacognitive Training (MCT) as a form of rehabilitating Theory of Mind (ToM) deficits in patients with Bipolar Disorder (BD) diagnosis, as well as, rehabilitation of deficits in Social Cognition. Therefore, this research is divided in two main steps: …

  • 28 May, 2022
Detection and Amelioration of Gamma Oscillation Abnormalities in Blast-Related Brain Injury (DAGABBI)

Combat Veterans of post-9/11 conflicts have experienced serious cognitive and emotional problems resulting from exposure to blasts. Recent work suggests that a critical factor influencing the consequences of blast exposure is distance from the blast, rather than the presence or absence of concussion symptoms. Exposure to blasts from a distance …

  • 21 Feb, 2022
  • 1 location
Effects of Blocking Blue Light at Night Post CABG AVR MVR CABG AVR or CABG MVR

Purpose The purpose of this study is to determine whether filtering out blue light at nighttime reduces post-surgical inflammation and/or moderates cognitive decline and mood and sleep alterations in patients undergoing elective CABG, AVR, MVR, CABG AVR, or CABG MVR surgery. If manipulating nighttime light in hospital rooms improves patient …

  • 20 Nov, 2021
  • 1 location
Fitness for Brain Optimization for Late-Life Depression

Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with …

  • 12 Aug, 2021
  • 1 location
TAME-PD - Physical Therapy, Atomoxetine and, Methylphenidate, to Enhance Gait and Balance in Parkinson's Disease (TAME-PD)

Gait and balance problems are a significant source of disability in patients with Parkinson disease. Physical therapy remains one of the main treatments. On the other hand some medications, such as methyphenidate and atomoxetine, have been tried with promising results. The outcomes in gait and balance in Parkinson disease after …

medication regimen
  • 23 Mar, 2022
  • 1 location