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Found 101 clinical trials
LBL-2016 for Children or Adolescents in China

The outcomes of children with lymphoblastic lymphoma (LBL) in China in the investigators' previous study were not unexpected. In this study, through further modification treatment protocols and strengthen domestic multicenter collaboration, the investigators try to improve survival for children with LBL when compared to the previous study.

cytotoxic chemotherapy
lymphoblastic lymphoma
daunorubicin
asparaginase
cyclophosphamide
  • 14 views
  • 23 Feb, 2022
  • 2 locations
Centrally Acting ACE Inhibition in SLE

SLE is a chronic autoimmune disease that often involves multiple systems and organs of the body. An autoimmune disease is one which your immune system attacks the cells and tissues in different parts of the body. SLE is characterized by inflammation that leads to tissue damage in many different organ …

ace inhibitor
sjogren's syndrome
autoimmune disease
corticosteroids
heart disease
  • 0 views
  • 29 Nov, 2021
  • 7 locations
Open-label, Single-blind, Observational, Comparative, Prospective, 36-month, Longitudinal, Controlled Study to Assess Efficacy of Siponimod (Mayzent®) on Microglia in Patients With Active Secondary Progressive Forms of Multiple Sclerosis

To assess the efficacy of Mayzent on microglia pathology in patients with active SPMS, as compared to the active control group of MS patients treated with the Ocrevus, as measured by changes in microglial activation in the lesional and non-lesional NAWM and NAGM and in the peri-plaque area of chronic …

MRI
secondary progressive multiple sclerosis
  • 0 views
  • 22 Oct, 2022
Study of Venetoclax in Combination With Chemotherapy in Pediatric Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Leukemia of Ambiguous Lineage

The purpose of this study is to test the safety and determine the best dose of venetoclax and cytarabine when given with or without idarubicin in treating pediatric patients with acute myeloid leukemia (AML) that did not respond to treatment (refractory) or has come back after treatment (relapsed). PRIMARY OBJECTIVE: …

idarubicin
ejection fraction
flow cytometry
induction chemotherapy
refractory acute myeloid leukemia (aml)
  • 108 views
  • 04 Oct, 2022
  • 2 locations
CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

The blood brain barrier (BBB) prevents some drugs from successfully reaching the target source. Convection-Enhanced Delivery (CED) is a method of direct infusion of drugs under controlled pressure to the tumor that may reduce systemic side effects of drugs in the patient. The purpose of this Phase I study is …

epilepsy
platelet count
anticonvulsants
anesthesia
seizures
  • 1 views
  • 27 Feb, 2022
B Cell Differentiation in MS (ABCD-SEP)

Interventional study with minimal risks and constraints, prospective, monocentric.

Accepts healthy volunteers
disease or disorder
clinically isolated syndrome
immunosuppressive agents
  • 0 views
  • 03 Mar, 2022
  • 1 location
Drug Repurposing Using Metformin for Improving the Therapeutic Outcome in Multiple Sclerosis Patients

This study aims to evaluate the effect of Metformin as add- on therapy for improving the outcome in RRMS patients.

MRI
interferon
brain mri
disease or disorder
diabetes
  • 0 views
  • 18 Jun, 2022
  • 1 location
Norwegian Study of Oral Cladribine and Rituximab in Multiple Sclerosis (NOR-MS) (NOR-MS)

The main aim and overall objective of the study is to assess whether rituximab is non-inferior to cladribine for the treatment of relapsing MS. Secondly, the investigators will test specific blood and MRI biomarkers that may contribute to future personalized treatment for MS patients. Furthermore, the investigators want to evaluate …

disease or disorder
MRI
rituximab
cladribine
  • 0 views
  • 15 May, 2022
  • 6 locations
Safety and Efficacy of Melatonin in Patients With Multiple Progressive Primary Sclerosis

Phase I / II randomized, single-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of melatonin administration combined with ocrelizumab in patients with Progressive Multiple Primary Sclerosis.

immunosuppressive agents
antioxidants
melatonin
ocrelizumab
  • 3 views
  • 04 Oct, 2022
  • 3 locations
International Phase I/II Expansion Trial of the MEK Inhibitor Selumetinib in Combination With Dexamethasone for the Treatment of Relapsed/Refractory RAS-pathway Mutated Paediatric and Adult Acute Lymphoblastic Leukaemia (SeluDex)

This trial is to investigate the combination of selumetinib and dexamethasone in the treatment of acute lymphoblastic leukaemia (ALL) in both adults and children. Phase I is to find the most suitable dose of selumetinib to safely give with dexamethasone. Phase II will use this dose to find out how …

dexamethasone
graft versus host disease
  • 80 views
  • 23 Oct, 2022
  • 16 locations