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Found 101 clinical trials
Study of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/Her2- Breast Cancer (ELECTRA)

This is a multi-site, global, open label study which includes a Phase 1b evaluation of elacestrant in combination with abemaciclib in women and men with with or without brain metastases from ER positive, HER-2 negative breast cancer. Phase 1b is designed to select the recommended phase 2 dose and will …

primary cancer
breast cancer
cancer
HER2
erbb2
  • 0 views
  • 07 Oct, 2022
  • 1 location
Intensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's Disease

Parkinson's disease (PD) is a progressive neurological disorder characterized by motor and non-motor symptoms such as rigidity, bradykinesia, resting tremor, cognitive and autonomic dysfunctions, gait and balance difficulties. The impairment of gait, balance and cognitive performances is partially responsive to dopaminergic medications. This emphasizes the importance of non-pharmacological interventions for …

dopamine
resting tremor
bradykinesia
tremor
motor symptoms
  • 0 views
  • 04 Oct, 2022
  • 1 location
Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL-RCT) (TRAIL-RCT)

The purpose of this study is to compare the effectiveness of a 4-week lower extremity telerehabilitation protocol with aims to improve lower extremity function to a 4-week attention-controlled education program on lower extremity clinical outcomes, quality of life, and healthcare resources utilization among community dwelling adults with stroke across Canada.

stroke
rehabilitation therapy
  • 0 views
  • 13 Mar, 2022
  • 1 location
Treating Depression on a Day-to-day Basis: Development of a Tool for Physicians Based on a Smartphone Application

Testing and validating an e-health (smartphone application) approach to better understand the determinants of day-to-day symptomatology in depression, medication adherence, and treatment efficacy in the goal of maximizing patient care.

structured clinical interview
depressed mood
  • 0 views
  • 29 Aug, 2021
  • 1 location
Arm Boot Camp Study: Evaluation of a Program to Increase Upper Limb Recovery After Stroke

This study will examine the feasibility and effect of a program that combines exercise and feedback from a wearable device on upper limb movement practice and function in individuals with stroke.

stroke
rehabilitation therapy
  • 12 views
  • 05 Jun, 2022
  • 5 locations
Cost-effectiveness and Efficacy of a Combined Intervention to Facilitate Motor Recovery Following Stroke

The purpose of this study is to investigate whether aerobic exercise improves the participant's ability to recover function in the arm and leg affected by the participant's stroke. The investigators are also calculating the cost effectiveness of the rehabilitation interventions.

hemorrhagic stroke
stroke
rehabilitation therapy
stroke rehabilitation
  • 7 views
  • 22 Oct, 2022
  • 1 location
SPINCOMS Biomarker Study (SPINCOMS)

To determine if biomarker-based CSF testing is reliably detecting differences between patients with Multiple Sclerosis (MS), different MS-subtypes, and other central nervous system (CNS

neurological disorder
nervous
disease or disorder
myelopathies
  • 0 views
  • 16 May, 2022
  • 1 location
Study to Assess the Efficacy of XPro™ in Patients With Mild Alzheimer's Disease With Biomarkers of Inflammation (MINDFuL)

The purpose of this study is to measure cognitive and biological biomarkers in subcutaneously administered XPro™ or placebo in patients with mild ADi.

dementia
alzheimer's disease
amyloid
mild dementia
cognitive assessment
  • 0 views
  • 04 Oct, 2022
  • 1 location
Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment

Encephalitis and meningitis are serious central nervous system diseases. There is currently a lack of comprehensive and accurate diagnosis and treatment pathways. Therefore, we conducted this

fever
lethargy
encephalitis
  • 0 views
  • 09 Jul, 2021
  • 6 locations
An Open-Label Extension of XPro1595 in Patients With Alzheimer's Disease

The goal of this Phase 2 Open-Label Extension (OLE) is to evaluate long-term safety, tolerability, and efficacy of XPro1595 on measures of cognition, function and brain quality in individuals with mild Alzheimer's Disease or MCI with biomarkers of inflammation.

cognitive assessment
alzheimer's disease
  • 0 views
  • 07 Oct, 2022
  • 1 location