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Found 341 clinical trials
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ACNS1123: Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT)

ACNS1123: Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT)

  • 170 views
  • 08 Nov, 2020
  • 1 location
Study of Talimogene Laherparepvec In Children With Advanced Non CNS Tumors

This is a phase 1 study to evaluate the safety of intralesional talimogene laherparepvec administration in pediatric subjects with advanced non-CNS tumors that are amenable to direct injection

  • 0 views
  • 20 Jun, 2021
  • 45 locations
Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant …

  • 167 views
  • 25 Jul, 2021
  • 126 locations
Study of Tozuleristide and the Canvas Imaging System in Pediatric Subjects With CNS Tumors Undergoing Surgery

distinguish between tumor and normal tissue during surgery in pediatric primary central nervous system tumors.

  • 0 views
  • 10 May, 2021
  • 10 locations
Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric Solid Tumors Including Central Nervous System Tumors

Phase 1 of this study, utilizing a rolling 6 design, will be conducted to determine a maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D), and to describe the toxicities of lenvatinib administered in combination with everolimus once daily to pediatric participants with recurrent/refractory solid tumors. Phase 2, utilizing …

  • 0 views
  • 26 Jan, 2021
  • 55 locations
AXL Inhibitor BGB324 in Treating Participants With Recurrent Glioblastoma Undergoing Surgery

This phase I trial studies how well AXL inhibitor BGB324 works in treating participants with glioblastoma that has come back who are undergoing surgery. AXL inhibitor BGB324 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

  • 0 views
  • 31 May, 2021
  • 8 locations
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection

The study is designed to use infusion of a non-radioactive, naturally occurring isotope of glucose (13C) in patients undergoing surgical resection for a newly identified brain mass to obtain the metabolic phenotype of the tumor, and correlate it with the histopathological diagnosis. In each patient, 13C NMR spectral analysis of …

  • 4 views
  • 11 Apr, 2021
  • 1 location
Effects of Keppra on Thinking Emotions and Balance in Elderly Healthy Volunteers

Epilepsy is a common disorder with an incidence of about 6 per 1000. The incidence progressively increases above age 50. By age 75, the incidence is two to three fold compared with any age group. Unfortunately, older individuals are especially at risk to incur significant side effects to anti-epileptic drugs. …

seizure
keppra
levetiracetam
anti-epileptic drug
antiepileptics
  • 4082 views
  • 07 Nov, 2020
  • 1 location
INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies

The aim of this trial is to determine preliminary activity of the combination treatment with nivolumab and entinostat in children and adolescents with high risk refractory/relapsed/progressive tumors harboring a high mutational load, high PD-L1 mRNA expression or focal MYC(N) amplification and explore activity in biomarker low tumors (low mutational load, …

nephroblastoma
malignant glioma
ependymoma
dipg
medulloblastoma
  • 0 views
  • 01 May, 2021
  • 13 locations
Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options

This is an open-label, Phase 1/2 multicenter dose escalation study in pediatric patients with relapsed or refractory extracranial solid tumors (Phase 1), with additional expansion cohorts (Phase 2) in patients with primary brain tumors harboring NTRK1/2/3 or ROS1 gene fusions, and extracranial solid tumors harboring NTRK1/2/3 or ROS1 gene fusions.

brain tumor
cns tumor
serum pregnancy test
cancer
entrectinib
  • 0 views
  • 03 Jul, 2021
  • 5 locations